A little like an abstract painting that refuses to represent recognizable subject matter in favor of expressing a "mood." Contrary to what others here have said, there *is* a story-line. The problem is that the underlying narrative structure is too basic to support so many elaborate, mystifying trappings.
It helps to know that the director based the movie on the experience she had when she was 10 and went to a hospital to get her appendix taken out. So given the main character's nightmarish attempt to figure out what's happening to him, we're basically seeing an elaborate series of puzzling visual metaphors for the director's disorienting personal experience as a child in hospital.
This movie isn't hiding anything or failing to be coherent. It just wants to be a darkly evocative visual collage instead of a straight-up narrative. Accordingly, it's rewardingly rich visually, but it's like a poem that sounds great but doesn't involve you in anything really important. All of the many unanswered questions it raises make it hard to let the visuals just wash over you.
In other words, behind all the evocative, disturbing imagery (again "unsettling" is the best word) it's *just* a retelling of a personal experience; there isn't a deeper message than "fear of the unknown." For me that wasn't enough.
The mood is conveyed. The story is told. It's just not terribly profound.