- Mother of Steffi Spira and Camilla Spira.
- Her husband Fritz Spira was murdered in a German Nazi Concentration Camp in 1943.
- She had two daughters who became actresses too - Steffie and Camilla Spira. Because they were Half Jews their lives were in danger as well. Camilla Spira was arrested in a transit camp but Lotte Spira claimed that she was the daughter of a extra-martial affair and that her father was a Christian. So she was able to protect her from deportation.
- Lotte Spira was married with the well-known actor Fritz Spira. Because he was a Jew the marriage was divorced by the pressure of the National Socialists. Fritz Spira fled but was arrested later and deported to a concentration camp where he was murdered.
- She became a demanded support actress in the 30s and she appeared in front of the camera for numerous feature movies.
- She entered the film business in 1923 with "Hallig Hooge" (1923).
- She began her stage career in 1904 in Berlin where she had her first performance at the Lustspielhaus. It followed other engagements at different theaters in Berlin.
- Her last cinematical works came in the wartime of the 40s into being with "Links der Isar - rechts der Spree" (1940), "Kora Terry" (1940), "Sechs Tage Heimaturlaub" (1941), "Zirkus Renz" (1943) and "Die Frau meiner Träume" (1944) which was released after her death.
- When Lotte Spira learned about the death of her former husband she died shortly afterwards at the age of only 60.
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