- Lived in London for 13 years before moving back to the United States. When he returned, he was too broke to afford his own place and he couldn't find any work. Luckily, Mary Steenburgen, whom he had met while making Noah's Ark (1999), took him in. He lived with the actress and her husband, actor Ted Danson, for a year. "Ted and Mary are my saviors ... I definitely wouldn't have made it without their psychological and emotional support".
- Was diagnosed with Bell's Palsy just before filming of the final season on Angel (1999) commenced. During the first episode, director Joss Whedon was careful to keep most of Alexis's shots on his right profile, as the left side of his face was fairly immobile at the time.
- His relationship with Alyson Hannigan was beset with many false starts at first. She asked him out when they first met on the Buffy the Vampire Slayer (1997) set, but he declined, citing a personal rule against dating coworkers. By the time he left the show, she was already dating someone else, but Alexis and Aly became friends regardless, eventually becoming so close that other people assumed they were dating. They finally decided to take the plunge and enter into a genuine romantic relationship, but not without fears that, if it didn't work out, they might wreck their friendship. Suffice to say, the relationship seems to be working very well.
- The series finale of Angel (1999) was his own 100th episode on the show.
- Was considered for the role of James Bond in Casino Royale.
- Denisof had been an excellent stage fencer for years when, as Joss Whedon says, he got to show off his skills in, among other episodes, Waiting in the Wings (2002).
- Married to Alyson Hannigan of Buffy the Vampire Slayer (1997) on October 11, 2003 in California.
- He and his wife, Alyson Hannigan, are godparents to Joss Whedon's son, Arden.
- Auditioned for the role of Conner Macleod in the Highlander TV series.
- Alexis and his wife, Alyson Hannigan, became the parents of their first child, a girl named Satyana Denisof, on Alyson's birthday of March 24, 2009 in Los Angeles.
- He has appeared in episodes of three different series with Eliza Dushku: Buffy the Vampire Slayer (1997), Angel (1999) and Dollhouse (2009). All three series were created by Joss Whedon.
- His first film appearance was in one of the two music videos for George Harrison's "Got My Mind Set on You." He was in the one that features a young man trying to attract the attention of a young woman at an arcade, rather than the one that shows Harrison sitting and singing the song in a room in a country estate; Denisof played the young man. Alexis said he only took the role in order to meet the former Beatle.
- Second daughter, Keeva Jane Denisof, was born on May 23, 2012 in Los Angeles.
- Was born in Maryland, raised in Seattle, and spent 3 years studying at the London Academy of Music and Dramatic Art.
- Named #3 of the Top Ten Sexiest Men of the Buffy / Angel universe in a fan poll by the Buffy the Vampire Slayer fanzine (2004).
- Alexis Denisof's father is of Russian, French, and Jewish descent, and his mother has Irish roots. Alexis is a first cousin, twice removed, of poet and critic Sonia Raiziss, whose father, biochemist George W. Raiziss, was Alexis' great-great-uncle. Alexis's mother has a Ph.D. and has taught Drama in Seattle, Washington.
- Alexis and Alyson Hannigan are expecting their second child [December 16, 2011].
- Appearing in Arthur Miller's "All My Sons", alongside Michael Byrne, at the Liverpool Playhouse. (September 2006)
- At age 13, he began attending St. Paul's School, a highly selective college-preparatory, co-educational boarding school in Concord, New Hampshire, affiliated with the Episcopal Church.
- He is the second actor to play Rossendale in Sharpe. Rossendale first appeared in Sharpe's Regiment. Though he isn't named in the dialogue. The credit's list him as Rossendale. He's the soldier who takes Sharpe (Sean Bean) to meet the Prince Regent (Julian Fellows). Though there he was played by Alexander Armstrong.
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