15 wins & 74 nominations
- 1991 Winner American Comedy Award
- Funniest Male Performer in a TV Series (Leading Role) Network, Cable or Syndication
- 1990 Nominee American Comedy Award
- Funniest Male Performer in a TV Series (Leading Role) Network, Cable or Syndication
- 1989 Nominee American Comedy Award
- Funniest Male Performer in a TV Series (Leading Role) Network, Cable or Syndication
- 2010 Nominee Primetime Emmy
- Outstanding Guest Actor in a Drama Series
For episode "The Next One's Gonna Go In Your Throat". For playing "Arthur Frobisher". - 2009 Nominee Primetime Emmy
- Outstanding Guest Actor in a Drama Series
For playing "Arthur Frobisher". For episode "They Had to Tweeze That Out of My Kidney".
- 2008 Nominee Golden Globe
- Best Performance by an Actor in a Supporting Role in a Series, Miniseries or Motion Picture Made for Television
- 2001 Nominee Golden Globe
- Best Performance by an Actor in a Television Series - Comedy or Musical
- 1993 Nominee Golden Globe
- Best Performance by an Actor in a Television Series - Comedy or Musical
- 1992 Nominee Golden Globe
- Best Performance by an Actor in a Television Series - Comedy or Musical
- 1991 Winner Golden Globe
- Best Performance by an Actor in a Television Series - Comedy or Musical
- 2005 Nominee Satellite Award
- Outstanding Actor in a Miniseries or a Motion Picture Made for Television
- 2003 Nominee Golden Satellite Award
- Best Actor in a Miniseries or a Motion Picture Made for Television
1993 Nominee People's Choice Award- Favorite Male TV Performer
- 1992 Nominee People's Choice Award
- Favorite Male TV Performer
- 1991 Nominee People's Choice Award
- Favorite Male TV Performer
- 1990 Nominee People's Choice Award
- Favorite Male TV Performer
- 1989 Nominee People's Choice Award
- Favorite Male TV Performer
- 2006 Nominee Actor
- Outstanding Performance by a Male Actor in a Television Movie or Miniseries
- 2017 Winner OFTA TV Hall of Fame
- Actors and Actresses
- 2018 Nominee Gold Derby TV Award
- Ensemble of the Year
Shared with: Kristen Bell · D'Arcy Carden · William Jackson Harper · Manny Jacinto · Marc Evan Jackson · Jameela Jamil · Jason Mantzoukas · Maribeth Monroe · Tiya Sircar
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