- Granddaughter of Ernest Hemingway and Elizabeth Hadley Richardson. Younger sister of Margaux Hemingway, born in 1955, and Joan Hemingway ("Muffet"), born in 1950.
- Named after a Cuban fishing village that was a favorite of her father and grandfather.
- Was the runner-up to Jodie Foster for the part of Iris Steensma in Martin Scorsese's Taxi Driver (1976).
- Mother, with Stephen Crisman, of Dree Hemingway (born December 4, 1987) and Langley Fox (born August 22, 1989).
- Was the first actress to ever appear nude on Tales from the Crypt (1989).
- Her first role was together with her sister Margaux in the movie Lipstick (1976), for which she was nominated as "Best Newcomer" for the Golden Globe Awards.
- Raised in Ketchum, Idaho; Los Angeles, Calif.; and New York City.
- Sister of Margaux Hemingway who died in 1996 when she committed suicide by lethal drug overdose.
- Auditioned for the leading role in Basic Instinct (1992), but lost out to actress Sharon Stone.
- Tenth cousin (same generation) of Cindy Crawford.
- Turned down the lead role in Splash (1984), which went to Daryl Hannah.
- She appeared in the music video and sang in the choir on the song "Voices That Care."
- Daughter of Jack Hemingway and Byra Louise Whittlesey ("Puck").
- Is portrayed by Chandra West in Love and Betrayal: The Mia Farrow Story (1995)
- Release of her book, "Mariel Hemingway's Healthy Living from the Inside Out: Every Woman's Guide to Real Beauty, Renewed Energy and a Radiant Life". (2007)
- Release of her book, "Finding My Balance: A Memoir". (2003)
- Release of her book, "Mariel's Kitchen: Simple Ingredients for a Delicious and Satisfying Life". (2009)
- Signed environmental activist Tom Weis' open letter calling on President Obama and Governor Romney to withdraw their support for the Keystone XL pipeline. Other signatories included climate scientist James Hansen and actors Daryl Hannah and Sheryl Lee. (September 2012)
- As of 2018, has never appeared in a film nominated for the Best Picture Oscar.
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