The Genesis Machine
Our Quest to Rewrite Life in the Age of Synthetic Biology
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Narrated by:
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Amy Webb
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Andrew Hessel
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Tim Campbell
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Landon Woodson
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Amanda Dolan
About this listen
What if the miracle that created mRNA vaccines is less a once-in-lifetime event and more the harbinger of the emerging age of synthetic biology? This fusion of biology and computers has a singular goal: to gain access to cells in order to write new—and possibly better—biological code.
Synthetic biology promises to reveal how life is created and how it can be re-created, enabling scientists to rewrite the rules of our reality. It could help us, for example, heal without prescription medications, grow meat without harvesting animals, or confront our looming climate catastrophe. Synthetic biology will determine the ways in which we conceive future generations and how we define family, how we identify disease and treat aging, where we make our homes, and how we nourish ourselves. Soon, we will program living, biological structures as though they were tiny computers.
But who should decide how to engineer living organisms? Whether engineered organisms should be planted, farmed, and released into the wild? Should there be limits to human enhancements? Amy Webb and Andrew Hessel’s riveting examination of synthetic biology and the bioeconomy provide the background for thinking through the upcoming risks and moral dilemmas posed by redesigning life, as well as the vast opportunities waiting for us on the horizon.
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p53: The Gene That Cracked the Cancer Code reveals the tale of the search for this gene, as well as the excitement of the hunt for new cures - the hype, the lost opportunities, the blind alleys, and the thrilling breakthroughs. As the long-anticipated revolution in cancer treatment tailored to each individual patient's symptoms starts to take off at last, p53 is still at the forefront of the game. This is a timely tale of scientific discovery and advances in our understanding of a disease that still affects more than one in three of us at some point in our lives.
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Excellent story! Unfortunate narration at start
- By Adriana on 12-25-14
By: Sue Armstrong
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Jump-Starting America
- How Breakthrough Science Can Revive Economic Growth and the American Dream
- By: Jonathan Gruber, Simon Johnson
- Narrated by: Robert Fass
- Length: 9 hrs and 57 mins
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The untold story of how America once created the most successful economy the world has ever seen and how we can do it again.
By: Jonathan Gruber, and others
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Data-ism
- The Revolution Transforming Decision Making, Consumer Behavior, and Almost Everything Else
- By: Steve Lohr
- Narrated by: Steve Lohr
- Length: 6 hrs and 33 mins
- Unabridged
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Coal, iron ore, and oil were the key productive assets that fueled the Industrial Revolution. Today data is the vital raw material of the information economy. The explosive abundance of this digital asset, more than doubling every two years, is creating a new world of opportunity and challenge. Data-ism is about this next phase, in which vast, Internet-scale data sets are used for discovery and prediction in virtually every field. It is a journey across this emerging world with people, illuminating narrative examples, and insights.
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More business case than serious analysis
- By Godfried Gubbels on 06-03-15
By: Steve Lohr
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Biomimicry
- Innovation Inspired by Nature
- By: Janine M. Benyus
- Narrated by: Callie Beaulieu
- Length: 14 hrs and 55 mins
- Unabridged
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Biomimicry is rapidly transforming life on earth. Biomimics study nature's most successful ideas over the past 3.5 million years, and adapt them for human use. The results are revolutionizing how materials are invented and how we compute, heal ourselves, repair the environment, and feed the world. Janine Benyus takes listeners into the lab and in the field with maverick thinkers as they: discover miracle drugs by watching what chimps eat when they're sick; learn how to create by watching spiders weave fibers; and many more examples.
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Dated but good
- By stephen taylor on 09-05-21
By: Janine M. Benyus
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The Compatibility Gene
- How Our Bodies Fight Disease, Attract Others, and Define Our Selves
- By: Daniel M. Davis
- Narrated by: Christopher Grove
- Length: 7 hrs and 48 mins
- Unabridged
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Most of the 25,000 genes we possess are the same for all of us. Compatibility genes are those that vary most from person to person and give each of us a unique molecular signature. These genes determine both the extent to which we are susceptible to a vast range of illnesses and the different ways each of us fights disease.
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If interested in medicine, got to read
- By Howard Sterling on 06-29-16
By: Daniel M. Davis
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Organic Manifesto
- How Organic Food Can Heal Our Planet, Feed the World, and Keep Us Safe
- By: Maria Rodale, Eric Scholsser - foreword
- Narrated by: Coleen Marlo
- Length: 5 hrs and 17 mins
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Drawing on findings from leading health researchers as well as conversations with both chemical and organic farmers from coast to coast, Maria Rodale irrefutably outlines the unacceptably high cost of chemical farming on our health and our environment. She traces the genesis of chemical farming and the rise of the immense companies that profit from it, bringing to light the government's role in allowing such practices to flourish.
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those in power must read and work upon it.
- By Jaktip on 12-20-17
By: Maria Rodale, and others
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Hood
- Trailblazer of the Genomics Age
- By: Luke Timmerman, David Baltimore
- Narrated by: Xe Sands
- Length: 10 hrs and 53 mins
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Lee Hood did that rarest of things. He enabled scientists to see things they couldn't see before and do things they hadn't dreamed of doing. Scientists can now sequence complete human genomes in a day, setting in motion a revolution that is personalizing medicine. Hood, a son of the American West, was an unlikely candidate to transform biology. But with ferocious drive, he led a team at Caltech that developed the automated DNA sequencer, the tool that paved the way for the Human Genome Project.
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A Revealing Biography
- By Jean on 07-27-17
By: Luke Timmerman, and others
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EMF*D
- 5G, Wi-Fi & Cell Phones: Hidden Harms and How to Protect Yourself
- By: Dr. Joseph Mercola
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The hazards of electronic pollution may once have been the stuff of science fiction, but now we know they're all too real. And with the advent of 5G ultra-wideband technology, the danger is greater than ever. Dr. Joseph Mercola, one of the world's foremost authorities on alternative health, has mined the scientific literature to offer a radical new understanding of how electromagnetic fields impact your body and mind.
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Top 10 best books ever
- By Priscilla Ferguson on 04-02-20
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Age of Discovery
- Navigating the Risks and Rewards of Our New Renaissance
- By: Ian Goldin, Chris Kutarna
- Narrated by: Mark Meadows
- Length: 11 hrs and 49 mins
- Unabridged
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Age of Discovery explores a world on the brink of a new Renaissance and asks: how do we share more widely the benefits of unprecedented progress? How do we endure the inevitable tumult generated by accelerating change? How do we each thrive through this tangled, uncertain time? From gains in health, education, wealth and technology to crises of conflict, disease and mass migration, the similarities between today's world and that of the 15th century are both striking and prophetic: we have been here before.
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A monotonous text disguised as casual reading.
- By Rob on 07-29-16
By: Ian Goldin, and others
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The Language of Life
- DNA and the Revolution in Personalized Medicine
- By: Francis S. Collins
- Narrated by: Greg Itzin
- Length: 10 hrs and 45 mins
- Unabridged
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Performance
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A scientific and medical revolution has crept up on us, based on study after study, from hundreds of laboratories around the world. It is no longer just a theoretical shift: every one of us will be touched by it, and many of us already have been. The meaning of disease, our understanding of the human body, and crucial decisions about what we all need to know and what choices we make about our health are at stake. Welcome to the new world of personalized medicine.
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The future of medicine
- By Ronald E on 04-12-10
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AI Superpowers
- China, Silicon Valley, and the New World Order
- By: Kai-Fu Lee
- Narrated by: Mikael Naramore
- Length: 9 hrs and 28 mins
- Unabridged
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Performance
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In AI Superpowers, Kai-fu Lee argues powerfully that because of these unprecedented developments in AI, dramatic changes will be happening much sooner than many of us expected. Indeed, as the US-Sino AI competition begins to heat up, Lee urges the US and China to both accept and to embrace the great responsibilities that come with significant technological power.
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Compelled to listen at 2x speed
- By LEE on 09-26-18
By: Kai-Fu Lee
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Headstrong
- 52 Women Who Changed Science-and the World
- By: Rachel Swaby
- Narrated by: Lauren Fortgang
- Length: 7 hrs and 1 min
- Unabridged
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Performance
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In 2013, the New York Times published an obituary for Yvonne Brill. It began: “She made a mean beef stroganoff, followed her husband from job to job, and took eight years off from work to raise three children.” It wasn’t until the second paragraph that readers discovered why the Times had devoted several hundred words to her life: Brill was a brilliant rocket scientist who invented a propulsion system to keep communications satellites in orbit, and had recently been awarded the National Medal of Technology and Innovation.
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Role models for young women
- By mtsuda90 on 06-25-16
By: Rachel Swaby
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What listeners say about The Genesis Machine
Average customer ratingsReviews - Please select the tabs below to change the source of reviews.
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- John D. Furber
- 04-16-22
Mostly accurate, worthwhile, informative
A comprehensive exploration of this important field. The authors got most of the facts right. The readers were good, easy to listen to. Only mispronounced a few technical terms. But if you have to choose only one, I recommend "The Code Breaker" by Walter Isaacson, about CRISPR and Jennifer Doudna.
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1 person found this helpful
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- Brian Garrett
- 05-17-22
The future is going to be crazy
Definitely lots of very interesting vectors the biological future is going to be taking. I'm hoping that some of the items they are working on are going to have a direct benefit to my longevity, but I'm afraid it's going to happen slightly slower than I want it to. Of course the darker side of this is the "dark science" that could be used in a negative way on humanity. Definitely a good read IMHO.
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1 person found this helpful
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- Rockin' Horse
- 03-11-22
A Warning
This book contains science surveyed without an agenda. It can be scary to hear facts
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1 person found this helpful
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- Andy
- 07-02-22
Thought provoking but politically biased
Very thought provoking and worth reading. The text lacks some level of detail to support its claims but does offer some broad brush speculations. Readers should be aware of obvious left wing political bias throughout the text, painting a less than balanced picture of events as well as obviously biased views of potential futures.
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7 people found this helpful
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- J
- 02-21-22
Great book on the possibilities of the future of Human biology
Preordered this a few months back because I’ve enjoy the previous works of Amy Webb. I’m in the tech industry but haven’t had any exposure to biological sciences since college about 10 years ago. The scenarios laid out may seem outlandish but if you see the real world examples cited throughout the book then they begin to seem plausible and realistic. The narrator did a great job and definitely recommend anyone to take a listen to it if they’re willing to have an open mind.
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2 people found this helpful
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- Rupert
- 04-17-22
Frightening
Evolution continues while some contemplates if it's true. There are the applications of so many methods within our universe yet we continue to think of God as a magician.
Thank you Amy and Andrew. And let's hail the TWIT audience, heard about this there.
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- Jim
- 03-26-22
Very Enlightening
I'm not well versed in the topic of synthetic biology so I found this book to be very informative. A lot of the concepts about DNA as property and potentially as a technology for things I'd never even considered. it's given me a new perspective and a lot of stuff to think about.
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1 person found this helpful
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- J. T. Holmes
- 01-10-23
Excellent overview of synthetic biology
Thoroughly enjoyed this overview of synthetic biology. The narration was excellent. We are clearly heading into unknown territory with all of the advances in cellular biology research. It is up to all of us to participate to ensure a positive outcome.
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- India Carlson
- 02-25-23
required for anyone interested in the future of biology
a balanced review of the history of synthetic biology that gives both positive and negatives of possibilities facing humanity and recommendations for making policy to guide the world
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- Austin
- 05-24-22
Really good synthesis of the field with an informed perspective; bad solutions
The first 90% of the book was really great! Really informative history including even recent advancements in synthetic biology. The last 10% with their solutions leave a lot to be desired. They softly peddle the “COVID was a made in a Chinese lab” conspiracy to argue against gain-of-function research. That left a really bad taste in my mouth. Their other “solutions” were a bit oversimplistic.
However, the first 90% of the book, especially the scenarios toward the end, make it worth it.
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2 people found this helpful