D2 dofamin retseptori

D2 dofamin retseptori, shuningdek, D₂R deb ham ataluvchi protein. Tarkibida insondagi DRD2 geni orqali kodlanadigan oqsil mavjud. Paul Greengard laboratoriyasida olib borgan qator izlanishlaridan soʻng, organizmdagi antipsixologik preparatlar kuchli taʼsir koʻrsatadigan qism dofamin retseptorlari ekanligini aytgan. D2 dofamin retseptorlari koʻpchilik antipsixotik dorilar uchun asosiy retseptor hisoblanadi. DRD2 ning tuzilishi atipik antipsixotik modda hisoblangan risperidon bilan kompleks tarzda aniqlangan^[1]^[2].

Manbalar

↑ "Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone". Nature 555 (7695): 269–273. March 2018. doi:10.1038/nature25758. PMID 29466326. PMC 5843546. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5843546.
↑ „NIMH » Molecular Secrets Revealed: Antipsychotic Docked in its Receptor“ (en). www.nimh.nih.gov (2018-yil 29-yanvar). Qaraldi: 2018-yil 26-noyabr.

[pmid29466326-1] "Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone". Nature 555 (7695): 269–273. March 2018. doi:10.1038/nature25758. PMID 29466326. PMC 5843546. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5843546.

[2] „NIMH » Molecular Secrets Revealed: Antipsychotic Docked in its Receptor“ (en). www.nimh.nih.gov (2018-yil 29-yanvar). Qaraldi: 2018-yil 26-noyabr.

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