Claire Dyson

http://www.ingentaconnect.com/content/scs/chimia/2015/00000069/00000001/art00003
Photodynamic therapy (PDT) has had mixed reception in the clinic, with most success stories being based on the ablative capacity of PDT. In these applications, maximal combinations of light and an exogenous photosensitiser are used to generate high levels of reactive oxygen species (ROS) that induce cell death either directly via necrosis or indirectly via vascular damage. However, recent advances in… Show more

http://www.ingentaconnect.com/content/scs/chimia/2015/00000069/00000001/art00003
Photodynamic therapy (PDT) has had mixed reception in the clinic, with most success stories being based on the ablative capacity of PDT. In these applications, maximal combinations of light and an exogenous photosensitiser are used to generate high levels of reactive oxygen species (ROS) that induce cell death either directly via necrosis or indirectly via vascular damage. However, recent advances in understanding the complex role of ROS in cell signalling have revealed potential new applications for PDT. For example, the proliferative effects of low level ROS could be applied to wound healing or immunomodulation. These effects should also be considered in the ablative applications. With the decades of chemical advances for ablative PDT at hand - including targeting mechanisms that modulate the therapeutic response - the application of PDT to other types of treatment could be relatively rapid. This review serves to summarise some of these developments and suggest future directions. Show less

Scientists can make molecular links between the food we eat and our health. The findings are becoming more amazing; and more sobering. Obesity is one of many diseases linked to poor nutrition. It is now clear that obesity is not just linked to the calories we associate with body fat, but with many micronutrients. Other diseases, including aging, neurodegeneration and allergies, also have strong and surprising links to nutrition. Some conditions are not just affected by what we eat today, but… Show more

Scientists can make molecular links between the food we eat and our health. The findings are becoming more amazing; and more sobering. Obesity is one of many diseases linked to poor nutrition. It is now clear that obesity is not just linked to the calories we associate with body fat, but with many micronutrients. Other diseases, including aging, neurodegeneration and allergies, also have strong and surprising links to nutrition. Some conditions are not just affected by what we eat today, but what are parents ate: nutrition annotates genes to change the way they are used. With such powerful effects on health, it is no wonder scientists are eager to share what they have found. Show less

Bioorganometallic Chemistry has become a mature area of science. This book considers naturally occuring bioorganometallic complexes, such as vitamin B12 and iron and nickel hydrogenases, including a possible role of the latter in the geochemical theory of the origin of life.
Chapter Title: Medicinal Properties of Organometallic Compounds (co-author: Paul Dyson)