InSysBio

InSysBio will participate in SITC’s 39th Annual Meeting which is to be held from November 6-10, 2024, at George R. Brown Convention Center in Houston, TX. Alexandra Diakonova, Maria Mironovich and Oleg Demin Jr are going to present InSysBio's Mechanistic modeling services and tools to support development of immunotherapies at Booth #1032 and 3 posters in frames of the Meeting. Check out our Booth and posters at #SITC24 ! https://lnkd.in/eNSmtHqQ #qsp #modelingandsimulation #biotech #biotechnology #immunotherapy #cancerresearch #drugdevelopment #biopharma #mechanisticmodeling

We would like to share InSysBio's experience on mechanistic modeling services for therapeutic proteins: mAbs, ADC, multispecific Abs, T-cell engagers. Our latest posters: https://lnkd.in/dRajixTW #qsp #modelingandsimulation #biotech #biotechnology #bioparma #mechanisticmodeling #drugdevelopment #mAbs #tcell #ADC

InSysBio announces its participation in #ACoP2024! Oleg Demin Jr, Scientific Director, Oncology & Immuno-Oncology, will be a co-chair and speaker of the session "Advancing QSP: From Virtual Patient To Digital Twin" on Tuesday, November 12. InSysBio team is going to present its modeling services & software to optimize drug development at the Booth #11 and 9 posters in frames of the Conference. Check out our posters and Booth at ACoP 2024! To learn more: https://lnkd.in/eRJkQeEU #qsp #modelingandsimulation #biotech #biotechnology #ACoP #biopharma #biopharmaceuticals #drugdevelopment

InSysBio launches Immune Response Template (IRT) version 3.6.3. IRT represents a QSP platform of immune system, simultaneously, being a tool for development of models related to immune system. Veronika Musatova, Head of IRT development team, comments on the new version, “As a result of the update, B cells model reflects the current views on the processes and sequence of this cell type development maintaining a balance between the model detail and complexity.” IRT is a part of InSysBio’s QSP software infrastructure being under constant upgrade. IRT v.3.6.3 gets a range of new features: https://lnkd.in/g4h4PG4g To learn the full content of Immune Response Template, please visit: https://irt.insysbio.com/ #qsp #modelingandsimulation #irt #immuneresponse #biotech #biopharma #biotechnology #pharmaceuticals #drugdevelopment #drugdiscovery

Congratulations to our colleagues Olga Ivanova and Tatiana Karelina whose article "Quantitative systems pharmacology model of α-synuclein pathology in Parkinson's disease-like mouse for investigation of passive immunotherapy mechanisms" has been published in #PSPJournal. See InSysBio's publications: https://lnkd.in/djnERFFj #qsp #modelingandsimulation #biotech #biotechnology #drugdevelopment #ParkinsonsDisease #Neuroscience #ASCPTJournalFamily

CYTOCON DB is InSysBio's tool to navigate across in vivo baseline levels. CYTOCON DB is designed for Quantitative Systems Pharmacology (QSP) modelers and scientists who deal with biomarker analysis. Information collected in the database enables them to save time typically spent for gathering and processing of literature and available data utilized for сalibration of a QSP model of a reference virtual patient (VP) against mean values of cell and cytokines concentrations. To experience CYTOCON DB or its Open version, please visit: https://lnkd.in/e9jUFZPC #qsp #modelingandsimulation #cytocon #database #biopharma #cytokines #pharmacometrics #biotech #biotechnology #pharmaceuticals #drugdevelopment #drugdiscovery

Today we would like to share the poster entitled "A Computational Environment for Simulations in Systems Biology" by Ivan Borisov, Evgeny Metelkin and Oleg Demin. The poster was presented in frames of JuliaCon2024. Our latest posters: https://lnkd.in/dRajixTW #qsp #modelingandsimulation #biotech #biotechnology #biopharma #biopharmaceuticals #drugdevelopment #juliacon2024 #julia

InSysBio team continues the development of the Blog which core idea is to share a unique collection of methodological materials on InSysBio's QSP modeling expertise. Alexander Stepanov, QSP modeler at InSysBio and fIVE DB team member, has lately contributed the new article "Estimation of kinetic parameters for cellular secretion from in vitro measurements".  Alexander comments on the article, "Secretion in eukaryotic cells is a fundamental process involving regulated release of a substance out of the cell. Receptor theory allows to derive an equation for secretion rate constant that depends on effectors. Unknown parameters of the equation can be determined via fitting against experimental data or estimated approximately without fitting by the way described in the paper. Derived equations for the parameters in secretion rate constant are implemented in fIVE DB." Learn more about fIVE DB: https://lnkd.in/eRET-NaH https://lnkd.in/er5Q5id4 #qsp #modelingandsimulation #biotech #biotechnology #biopharma #drugdevelopment #biopharmaceuticals #secretion #blog

InSysBio team was thrilled to present their posters at PAGE 2024! Now the posters are available on our website: https://lnkd.in/dRajixTW #qsp #modelingandsimulation #biotech #biotechnology #biopharma #drugdevelopment #PAGE2024 #biopharmaceuticals

Meet InSysBio team at #PAGE2024, Booth #15! Don't miss our posters: Thursday, June 27, 09:50-11:20: III-033 "Cis-binding of bispecific antibodies: effect of additional valency and dose on the antibody-target complexes formation on the example of antibody CTX8371" by Veronika Musatova, Oleg Demin Jr, Dmitry Shchelokov, Oleg Demin Wednesday-Friday: S-03 "Secure and Scalable Computational Environment for Virtual Patients Simulations" by Ivan Borisov, Evgeny Metelkin #qsp #modelingandsimulation #biotech #biotechnology #biopharma #drugdevelopment