British Toxicology Society (BTS)

Our new Partnership and Impact funding scheme focuses on accelerating the adoption of existing 3Rs methods into routine practice, building confidence in the method to realise the maximum scientific and 3Rs potential: https://lnkd.in/dZj4eHXX Effectively communicating how your proposed research will achieve an immediate 3Rs impact is essential for securing funding. Our guidance describes how to build a 3Rs case, including what types of metrics to use for the different Rs: https://lnkd.in/d8PVdwzq Further information on applying this guidance, including common errors and examples, can be found in our recorded webinar: https://lnkd.in/dU-fw3Ne

The presence of impurities and degradation products in drugs is unavoidable but it is critical that these unintended products are controlled to ensure patient safety. Although general study design considerations are discussed in the ICH Q3A/B guidance, an IQ DruSafe Impurities Working Group survey identified key aspects of the qualification process that could benefit from harmonization. Attend the 2024 ACT Annual Meeting Symposium chaired by Catrin Hasselgren and Michelle Kenyon for a discussion surrounding recent recommendations for a harmonized approach that includes a 3R-based study design. Register for the 2024 ACT Annual Meeting today: https://lnkd.in/g4AqQHzv

Deadline for registration - June 21st "An introduction to the principles of regulatory toxicology: present and future" MODULE 1 REGISTRATION NOW OPEN!  As part of the latest phase of the British Toxicology Society (BTS) Skills Gap Initiative, the Steering Committee and Advisory Board are very pleased to announce the launch of the first of a series of training modules ‘An introduction to the principles of regulatory toxicology: present and future’. This training module, which is aimed primarily at early career regulatory toxicologists in government and industry, will consist of six 2-hour webinars followed by a final in-person full-day workshop.  The training will be delivered by subject matter experts from government, academia and industry, and will run from June 2024 with the in-person workshop to be held in January 2025. Participant numbers are limited, and early registration is encourages. Further details on the module content, timings and information on registration are available here: https://lnkd.in/e6gKVCHd. Details of further training modules, planned from January 2025, will be available soon on the BTS website.

It was really great that we were able to capture these Vox pops at DiscoTox24. They serve as a timely reminder of why the DiscoTox meeting exists but also provides a great platform for capturing in-situ thoughts and feelings on the overall fortes of the meeting. Combined with replies to our questionnaire, I can already see where I will be leading DiscoTox25 next year. Watch this space ….! Thanks again to the following companies that kept DiscoTox24 alive: Agilent Technologies | Axol Bioscience Ltd. | Greiner Bio-One International | Promega UK | Simulations Plus, Inc. A huge thank you to Novartis | ApconiX | AstraZeneca for their headline sponsorships. One person no one will have seen that very much kept the coal-burners glowing was Holly Goodsell. A MASSIVE THANK YOU from me!

Cambridge Alliance on Medicines Safety Event: "Alternative Approaches for Human-Relevant Toxicity Assessment" 10 July 2024 Cambridge/UK, and online More information at: https://lnkd.in/e4p4yZWV

ECETOC Workshop: "Integrating AI into chemical safety assessment – Opportunities, challenges, and the path forward" 16/17 October 2024, Sophia Antipolis, France and online More information at https://lnkd.in/dyNrc3Jr

A very enjoyable Discovery Tox conference at The DISC last week. 🥼 Brilliant Science 🏛️ Great Venue 👫 Fantastic opportunity to connect Huge thank you to AstraZeneca and the British Toxicology Society (BTS) organisers. A great excuse to visit my hometown and spend some needed face to face time with my colleagues Jon Sparkes and Frances Hall PhD.

It was a pleasure to give a short talk and present a poster at the British Toxicology Society (BTS) DiscoTox meeting yesterday, and recently at the BTS Congress. I'm thoroughly enjoying the unique position of working closely with the team at AstraZeneca and the MRC Toxicology Unit. Thank you to everyone who has supported my work, and to DefiniGEN, for supplying their Opti-HEP cells to use as an in-vitro hepatocyte model.

Congratulations Miles. Well deserved.

SafeBridge Announces the TAK SCHOLARSHIP PROGRAM Call for applications for TAK Scholarship Two places remaining Closing Date: 14th June 2024   The TAK Scholarship honours Dr Tracy A Kimmel DABT, a valued SafeBridge colleague and exceptional toxicologist who unexpectedly passed in October 2021.   The TAK Scholarship facilitates the training of exceptional graduate students and/or postdocs interested in developing skills in pharmaceutical risk assessment, by attending a Potent Compound Safety “Boot Camp”®. SafeBridge Regulatory & Life Sciences Group (SafeBridge) regularly conducts its premier training, the Potent Compound Safety “Boot Camp”® at sites across the U.S. and the globe.   This three-day course in potent compound safety is designed for Environmental Health & Safety professionals, including toxicologists and industrial hygienists, who need to understand the critical concepts of evaluating and safely handling pharmaceutical compounds. The intensive curriculum, taught by industry leaders, focuses on: Evaluation of compound potency and toxicity. Sampling and monitoring protocols. Control technologies. Effective investigation and communication approaches. Through lectures, case studies, videos, and exercises that address potent compound safety issues in pharmaceutical discovery, development, and manufacturing. The course leverages a systematic approach to successfully support drug R&D and manufacturing operations.   Eligibility: Graduate Students and Postdocs in the field of Toxicology and/or Industrial Hygiene.   Requirements: Please submit your Curriculum Vitae along with a brief personal statement of no more than 250 words describing the potential applicability of this training towards your career goals. Event Details: Date: June 18-20, 2024 Location: Clayton Hotel - Cambridge, UK Award: The scholarship includes the cost of the training and meals. Travel to the venue and hotel costs are not covered.   If you are interested, please email Dr Robert Sussman at [email protected] with your details by 12.00 noon on the 14th June 2024.