CD59

CD59
Uygun yapılar PDB Ortolog araması: PDBe RCSB PDB kimlik kodlarının listesi 1CDQ, 1CDR, 1CDS, 1ERG, 1ERH, 2J8B, 2OFS, 2UWR, 2UX2, 4BIK
Tanımlayıcılar
Başka adlar	CD59
Dış kimlikler	OMIM: 107271 MGI: 1888996 HomoloGene: 56386 GeneCards: CD59
Gen yerleşimi (İnsan) Krom. 11. Kromozom (insan) Bant 11p13 Başlangıç 33,703,010 bç Bitiş 33,736,479 bç
RNA ekspresyonu deseni Daha çok ekspresyon verisi başvurusu
Gen ontolojisi Moleküler işlevi • GO:0001948, GO:0016582 protein bağlanması • complement binding Hücresel bileşeni • Vezikül • endoplasmic reticulum membrane • membrane • focal adhesion • Golgi membrane • Hücre zarı • extracellular region • cell surface • compact myelin • anchored component of external side of plasma membrane • ER to Golgi transport vesicle membrane • anchored component of membrane • Miyolem • extracellular exosome • endoplasmic reticulum-Golgi intermediate compartment membrane • extracellular space • specific granule membrane • tertiary granule membrane • transport vesicle Biyolojik süreci • Koagülasyon • negative regulation of apoptotic process • negative regulation of activation of membrane attack complex • endoplasmic reticulum to Golgi vesicle-mediated transport • cell surface receptor signaling pathway • COPII vesicle coating • positive regulation of T cell proliferation • regulation of complement activation • cell activation • neutrophil degranulation • regulation of complement-dependent cytotoxicity Kaynaklar:Amigo / QuickGO
Ortologlar
Türler	İnsan	Fare
Entrez	966	333883
Ensembl	ENSG00000085063	ENSMUSG00000068686
UniProt	P13987 Q6FHM9	P58019
RefSeq (mRNA)	NM_203331 NM_000611 NM_001127223 NM_001127225 NM_001127226 NM_001127227 NM_203329 NM_203330	NM_181858 NM_001368215
RefSeq (protein)	NP_000602 NP_001120695 NP_001120697 NP_001120698 NP_001120699 NP_976074 NP_976075 NP_976076 NP_000602.1 NP_001120695.1 NP_001120697.1 NP_001120698.1 NP_001120699.1 NP_976074.1 NP_976075.1 NP_976076.1	NP_862906 NP_001355144
Yerleşim (UCSC)	Krom. 11: 33.7 – 33.74 Mb	n/a
PubMed araması
Vikiveri
İnsan'ı Gör/Düzenle Fare'yi Gör/Düzenle

CD59 glikoproteini, MAC baskılayıcı protein (MAC-IP), membran reaktif liziz inhibitörü veya protektin olarak da bilinen, insanlarda CD59 geni tarafından ile kodlanan bir proteindir. LY6/uPAR/alfa-nörotoksin protein ailesine aittir.

CD59, bir glikofosfatidilinozitol (GPI) tutucusu yoluyla konak hücrelere bağlanır. Kompleman etkinleşmesi, konak hücrelerinde C5b678 çökeltilmesine yol açtığında, CD59, C9'un polimerleşmesini ve membran atak kompleksini oluşturmasını önleyebilir. Ayrıca, CD59-CD9 kompleksinin endositozu gibi etkin önlemler alması için hücreye sinyal verebilir.

Kırmızı kan hücreleri üzerinde CD59 dışa vurumunu ve çürüme hızlandırıcı faktörü azaltan GPI'yi etkileyen mutasyonlar paroksismal noktürnal hemoglobinüri ile sonuçlanır.

HIV, insan sitomegalovirüsü ve vaksinya gibi virüsler, kompleman tarafından lizizlerini önlemek için konak hücre CD59'unu kendi viral zarflarına katar.

Konuyla ilgili yayınlar

• Tandon N, Morgan BP, Weetman AP (1992). "Expression and function of membrane attack complex inhibitory proteins on thyroid follicular cells". Immunology. 75 (2). ss. 372-7. PMC 1384722 $2. PMID 1372592. 
• Holmes CH, Simpson KL, Okada H, Okada N, Wainwright SD, Purcell DF, Houlihan JM (1992). "Complement regulatory proteins at the feto-maternal interface during human placental development: distribution of CD59 by comparison with membrane cofactor protein (CD46) and decay accelerating factor (CD55)". Eur. J. Immunol. 22 (6). ss. 1579-1585. doi:10.1002/eji.1830220635. PMID 1376264. 
• Hahn WC, Menu E, Bothwell AL, Sims P, Bierer B (1992). "Overlapping but nonidentical binding sites on CD2 for CD58 and a second ligand CD59". Science. 256 (5065). ss. 1805-1807. doi:10.1126/science.1377404. PMID 1377404. 
• Ninomiya H, Sims PJ (1992). "The human complement regulatory protein CD59 binds to the alpha-chain of C8 and to the "b"domain of C9". J. Biol. Chem. 267 (19). ss. 13675-80. PMID 1377690. 
• Petranka JG, Fleenor DE, Sykes K, Kaufman RE, Rosse WF (1992). "Structure of the CD59-encoding gene: further evidence of a relationship to murine lymphocyte antigen Ly-6 protein". Proc. Natl. Acad. Sci. U.S.A. 89 (17). ss. 7876-7879. doi:10.1073/pnas.89.17.7876. PMC 49817 $2. PMID 1381503. 
• Motoyama N, Okada N, Yamashina M, Okada H (1992). "Paroxysmal nocturnal hemoglobinuria due to hereditary nucleotide deletion in the HRF20 (CD59) gene". Eur. J. Immunol. 22 (10). ss. 2669-2673. doi:10.1002/eji.1830221029. PMID 1382994. 
• Rooney IA, Morgan BP (1992). "Characterization of the membrane attack complex inhibitory protein CD59 antigen on human amniotic cells and in amniotic fluid". Immunology. 76 (4). ss. 541-7. PMC 1421564 $2. PMID 1383132. 
• Tone M, Walsh LA, Waldmann H (1992). "Gene structure of human CD59 and demonstration that discrete mRNAs are generated by alternative polyadenylation". J. Mol. Biol. 227 (3). ss. 971-976. doi:10.1016/0022-2836(92)90239-G. PMID 1383553. 
• Philbrick WM, Palfree RG, Maher SE, Bridgett MM, Sirlin S, Bothwell AL (1990). "The CD59 antigen is a structural homologue of murine Ly-6 antigens but lacks interferon inducibility". Eur. J. Immunol. 20 (1). ss. 87-92. doi:10.1002/eji.1830200113. PMID 1689664. 
• Sawada R, Ohashi K, Anaguchi H, Okazaki H, Hattori M, Minato N, Naruto M (1990). "Isolation and expression of the full-length cDNA encoding CD59 antigen of human lymphocytes". DNA Cell Biol. 9 (3). ss. 213-220. doi:10.1089/dna.1990.9.213. PMID 1692709. 
• Yamashina M, Ueda E, Kinoshita T, Takami T, Ojima A, Ono H, Tanaka H, Kondo N, Orii T (1990). "Inherited complete deficiency of 20-kilodalton homologous restriction factor (CD59) as a cause of paroxysmal nocturnal hemoglobinuria". N. Engl. J. Med. 323 (17). ss. 1184-1189. doi:10.1056/NEJM199010253231707. PMID 1699124. 
• Rooney IA, Morgan BP (1991). "Protection of human amniotic epithelial cells (HAEC) from complement-mediated lysis: expression on the cells of three complement inhibitory membrane proteins". Immunology. 71 (3). ss. 308-11. PMC 1384423 $2. PMID 1702747. 
• Watts MJ, Dankert JR, Morgan EP (1990). "Isolation and characterization of a membrane-attack-complex-inhibiting protein present in human serum and other biological fluids". Biochem. J. 265 (2). ss. 471-7. doi:10.1042/bj2650471. PMC 1136908 $2. PMID 2302178. 
• Okada H, Nagami Y, Takahashi K, Okada N, Hideshima T, Takizawa H, Kondo J (1989). "20 KDa homologous restriction factor of complement resembles T cell activating protein". Biochem. Biophys. Res. Commun. 162 (3). ss. 1553-1559. doi:10.1016/0006-291X(89)90852-8. PMID 2475111. 
• Davies A, Simmons DL, Hale G, Harrison RA, Tighe H, Lachmann PJ, Waldmann H (1989). "CD59, an LY-6-like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells". J. Exp. Med. 170 (3). ss. 637-654. doi:10.1084/jem.170.3.637. PMC 2189447 $2. PMID 2475570. 
• Sawada R, Ohashi K, Okano K, Hattori M, Minato N, Naruto M (1989). "Complementary DNA sequence and deduced peptide sequence for CD59/MEM-43 antigen, the human homologue of murine lymphocyte antigen Ly-6C". Nucleic Acids Res. 17 (16). s. 6728. doi:10.1093/nar/17.16.6728. PMC 318369 $2. PMID 2476718. 
• Sugita Y, Tobe T, Oda E, Tomita M, Yasukawa K, Yamaji N, Takemoto T, Furuichi K, Takayama M (1990). "Molecular cloning and characterization of MACIF, an inhibitor of membrane channel formation of complement". J. Biochem. 106 (4). ss. 555-7. doi:10.1093/oxfordjournals.jbchem.a122893. PMID 2606909. 
• Bora NS, Gobleman CL, Atkinson JP, Pepose JS, Kaplan HJ (1994). "Differential expression of the complement regulatory proteins in the human eye". Invest. Ophthalmol. Vis. Sci. 34 (13). ss. 3579-84. PMID 7505007. 
• Kieffer B, Driscoll PC, Campbell ID, Willis AC, Van Der Merwe PA, Davis SJ (1994). "Three-dimensional solution structure of the extracellular region of the complement regulatory protein CD59, a new cell-surface protein domain related to snake venom neurotoxins". Biochemistry. 33 (15). ss. 4471-4482. doi:10.1021/bi00181a006. PMID 7512825. 
• Kennedy SP, Rollins SA, Burton WV, Sims PJ, Bothwell AL, Squinto SP, Zavoico GB (1994). "Protection of porcine aortic endothelial cells from complement-mediated cell lysis and activation by recombinant human CD59". Transplantation. 57 (10). ss. 1494-501. doi:10.1097/00007890-199405000-00017. PMID 7515200. 

Dış bağlantılar

• Medical Subject Headings CD59 Antigen
• Human CD59 24 Haziran 2018 tarihinde Wayback Machine sitesinde arşivlendi. genome location and CD59 28 Nisan 2018 tarihinde Wayback Machine sitesinde arşivlendi. gene details page in the UCSC Genome Browser.