İçeriğe atla

CD3D

Vikipedi, özgür ansiklopedi
CD3D
Uygun yapılar
PDBOrtolog araması: PDBe RCSB
Tanımlayıcılar
Başka adlarCD3D
Dış kimliklerOMIM: 186790 MGI: 88331 HomoloGene: 585 GeneCards: CD3D
Gen yerleşimi (İnsan)
11. Kromozom (insan)
Krom.11. Kromozom (insan)[1]
11. Kromozom (insan)
CD3D için genom yerleşimi
CD3D için genom yerleşimi
Bant11q23.3Başlangıç118,339,075 [1]
Bitiş118,342,705 [1]
RNA ekspresyonu deseni
Daha çok ekspresyon verisi başvurusu
Ortologlar
TürlerİnsanFare
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001040651
NM_000732

NM_013487

RefSeq (protein)

NP_000723
NP_001035741

NP_038515

Yerleşim (UCSC)Krom. 11: 118.34 – 118.34 Mbn/a
PubMed araması[2][3]
Vikiveri
İnsan'ı Gör/DüzenleFare'yi Gör/Düzenle

T hücresi yüzey glikoproteini CD3 delta zinciri, CD3D geni tarafından kodlanan bir insan proteinidir.[4]

CD3D'nin CD8A ile etkileşime girdiği gösterilmiştir.[5]

Ayrıca bakınız

[değiştir | kaynağı değiştir]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000167286 - Ensembl, May 2017
  2. ^ "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine. 
  3. ^ "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine. 
  4. ^ "Entrez Gene: CD3D CD3d molecule, delta (CD3-TCR complex)". 5 Aralık 2010 tarihinde kaynağından arşivlendi. 
  5. ^ Doucey (Jan 2003). "CD3 delta establishes a functional link between the T cell receptor and CD8". J. Biol. Chem. 278 (5). Amerika Birleşik Devletleri. ss. 3257-64. 

Konuyla ilgili yayınlar

[değiştir | kaynağı değiştir]
  • "Composition of TCR-CD3 complex in human intestinal intraepithelial lymphocytes: lack of Fc epsilon RI gamma chain". Int. Immunol. 7 (8). 1996. ss. 1237-41. 
  • Li CJ (2007). "Therapeutic biology: checkpoint pathway activation therapy, HIV Tat, and transkingdom RNA interference". J. Cell. Physiol. 209 (3). ss. 695-700. 
  • "Ontogeny of human natural killer (NK) cells: fetal NK cells mediate cytolytic function and express cytoplasmic CD3 epsilon, delta proteins". J. Exp. Med. 175 (4). 1992. ss. 1055-66. 
  • "The antigen-specific induction of normal human lymphocytes in vitro is down-regulated by a conserved HIV p24 epitope". Immunol. Lett. 33 (3). 1992. ss. 307-14. 
  • "The CD3-gamma and CD3-delta subunits of the T cell antigen receptor can be expressed within distinct functional TCR/CD3 complexes". EMBO J. 10 (4). 1991. ss. 903-12. 
  • "Cloning of a novel cell type from human fetal liver expressing cytoplasmic CD3 delta and epsilon but not membrane CD3". Int. Immunol. 3 (4). 1991. ss. 353-7. 
  • "A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium influx". Cell. Immunol. 137 (1). 1991. ss. 1-13. 
  • "Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway". J. Clin. Invest. 86 (6). 1991. ss. 2117-24. 
  • "Immunoregulatory effect of a synthetic peptide corresponding to a region of protein p24 of HIV". Folia Biol. (Praha). 36 (1). 1990. ss. 71-7. 
  • "The implications of subunit interactions for the structure of the T cell receptor-CD3 complex". Eur. J. Immunol. 20 (2). 1990. ss. 299-305. 
  • "Dephosphorylation of the human T lymphocyte CD3 antigen". Eur. J. Biochem. 181 (1). 1989. ss. 55-65. 
  • "Physical linkage of three CD3 genes on human chromosome 11". EMBO J. 6 (10). 1988. ss. 2953-7. 
  • "Isolation and characterization of a cDNA clone encoding the murine homologue of the human 20K T3/T-cell receptor glycoprotein". Nature. 314 (6011). 1985. ss. 542-4. 
  • "Exon/intron organization of the genes coding for the delta chains of the human and murine T-cell receptor/T3 complex". Proc. Natl. Acad. Sci. U.S.A. 83 (9). 1986. ss. 2944-8. 
  • "Evolutionary relationship between the T3 chains of the T-cell receptor complex and the immunoglobulin supergene family". Proc. Natl. Acad. Sci. U.S.A. 84 (21). 1987. ss. 7649-53. 
  • "T3 delta pre-mRNA is transcribed from a non-TATA promoter and is alternatively spliced in human T cells". EMBO J. 5 (6). 1986. ss. 1245-52. 
  • "Isolation of cDNA clones encoding the 20K T3 glycoprotein of human T-cell receptor complex". Nature. 312 (5993). 1985. ss. 413-8. 
  • "Costimulatory properties of the human CD4 molecule: enhancement of CD3-induced T cell activation by human immunodeficiency virus type 1 through viral envelope glycoprotein gp120". AIDS Res. Hum. Retroviruses. 9 (10). 1994. ss. 945-55. 17 Şubat 2020 tarihinde kaynağından arşivlendi. Erişim tarihi: 17 Şubat 2020. 
  • "An HIV p24 heptapeptide down-regulates antigen-specific responses in vitro interfering at the level of the T3-Ti complex". Cell. Immunol. 156 (2). 1994. ss. 286-95. 

Dış bağlantılar

[değiştir | kaynağı değiştir]
  • Human CD3D genome location and CD3D gene details page in the UCSC Genome Browser.
  • Overview of all the structural information available in the PDB for UniProt: P04234 (T-cell surface glycoprotein CD3 delta chain) at the PDBe-KB.
  • PDBe-KB 23 Temmuz 2019 tarihinde Wayback Machine sitesinde arşivlendi. provides an overview of all the structure information available in the PDB for Human T-cell surface glycoprotein CD3 delta chain (CD3D)