ACAD8

ACAD8
Uygun yapılar
PDB	Ortolog araması: PDBe RCSB
PDB kimlik kodlarının listesi
	1RX0
Tanımlayıcılar
Başka adlar	ACAD8
Dış kimlikler	OMIM: 604773 MGI: 1914198 HomoloGene: 8662 GeneCards: ACAD8
Gen yerleşimi (İnsan)
Krom.	11. Kromozom (insan)
Bitiş	134,265,855 bç
RNA ekspresyonu deseni
	Daha çok ekspresyon verisi başvurusu
Gen ontolojisi
Moleküler işlevi	• oxidoreductase activity, acting on the CH-CH group of donors; • oxidoreductase activity; • acyl-CoA dehydrogenase activity; • flavin adenine dinucleotide binding;
Hücresel bileşeni	• mitochondrial matrix; • mitokondri;
Biyolojik süreci	• valine catabolic process; • branched-chain amino acid catabolic process; • GO:0009373 regulation of transcription, DNA-templated; • transcription, DNA-templated; • lipid metabolism;
	Kaynaklar:Amigo / QuickGO
Ortologlar
	27034
	66948
	ENSG00000151498
	ENSMUSG00000031969
	Q9UKU7
	Q9D7B6
	NM_014384
	NM_025862
	NP_055199
	NP_080138
	Vikiveri
İnsan'ı Gör/Düzenle	Fare'yi Gör/Düzenle

İzobütiril-CoA dehidrogenaz, mitokondriyal, insanların 11. kromozomunda yer alan ACAD8 geni tarafından kodlanan bir enzimdir.^[4]^[5]

Kaynakça

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000151498 - Ensembl, May 2017
^ "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Telford EA, Moynihan LM, Markham AF, Lench NJ (Sep 1999). "Isolation and characterisation of a cDNA encoding the precursor for a novel member of the acyl-CoA dehydrogenase gene family". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1446 (3). ss. 371-6. doi:10.1016/s0167-4781(99)00102-5. PMID 10524212.
^ "Entrez Gene: ACAD8 acyl-Coenzyme A dehydrogenase family, member 8". 6 Mart 2010 tarihinde kaynağından arşivlendi. Erişim tarihi: 17 Ocak 2024.

Ek okuma

Näär AM, Beaurang PA, Zhou S, Abraham S, Solomon W, Tjian R (Apr 1999). "Composite co-activator ARC mediates chromatin-directed transcriptional activation". Nature. 398 (6730). ss. 828-32. Bibcode:1999Natur.398..828N. doi:10.1038/19789. PMID 10235267.
Andresen BS, Christensen E, Corydon TJ, Bross P, Pilgaard B, Wanders RJ, Ruiter JP, Simonsen H, Winter V, Knudsen I, Schroeder LD, Gregersen N, Skovby F (Nov 2000). "Isolated 2-methylbutyrylglycinuria caused by short/branched-chain acyl-CoA dehydrogenase deficiency: identification of a new enzyme defect, resolution of its molecular basis, and evidence for distinct acyl-CoA dehydrogenases in isoleucine and valine metabolism". American Journal of Human Genetics. 67 (5). ss. 1095-103. doi:10.1086/303105. PMC 1288551 $2. PMID 11013134.
Nguyen TV, Andresen BS, Corydon TJ, Ghisla S, Abd-El Razik N, Mohsen AW, Cederbaum SD, Roe DS, Roe CR, Lench NJ, Vockley J (2003). "Identification of isobutyryl-CoA dehydrogenase and its deficiency in humans". Molecular Genetics and Metabolism. 77 (1–2). ss. 68-79. doi:10.1016/S1096-7192(02)00152-X. PMID 12359132.
Battaile KP, Nguyen TV, Vockley J, Kim JJ (Apr 2004). "Structures of isobutyryl-CoA dehydrogenase and enzyme-product complex: comparison with isovaleryl- and short-chain acyl-CoA dehydrogenases". The Journal of Biological Chemistry. 279 (16). ss. 16526-34. doi:10.1074/jbc.M400034200  . PMID 14752098.
Ma J, Dempsey AA, Stamatiou D, Marshall KW, Liew CC (Mar 2007). "Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects". Atherosclerosis. 191 (1). ss. 63-72. doi:10.1016/j.atherosclerosis.2006.05.032. PMID 16806233.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000151498 - Ensembl, May 2017

[2] "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10524212-4] Telford EA, Moynihan LM, Markham AF, Lench NJ (Sep 1999). "Isolation and characterisation of a cDNA encoding the precursor for a novel member of the acyl-CoA dehydrogenase gene family". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1446 (3). ss. 371-6. doi:10.1016/s0167-4781(99)00102-5. PMID 10524212.

[entrez-5] "Entrez Gene: ACAD8 acyl-Coenzyme A dehydrogenase family, member 8". 6 Mart 2010 tarihinde kaynağından arşivlendi. Erişim tarihi: 17 Ocak 2024.

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