PD-168,077 je lek koji deluje kao dopaminski agonist. On je selektivan za D4 podtip,[1][2] i koristi se za istraživanje uloge tog receptora u mozgu,[3][4][5] posebno u pogledu njegove uloge u učenju i memoriji.[6]
^Clifford JJ, Waddington JL (2000). „Topographically based search for an "Ethogram" among a series of novel D(4) dopamine receptor agonists and antagonists”. Neuropsychopharmacology. 22 (5): 538—44. PMID10731629. doi:10.1016/S0893-133X(99)00141-4.
^Matulenko MA, Hakeem AA, Kolasa T, Nakane M, Terranova MA, Uchic ME, Miller LN, Chang R, Donnelly-Roberts DL, Namovic MT, Moreland RB, Brioni JD, Stewart AO (2004). „Synthesis and functional activity of (2-aryl-1-piperazinyl)-N-(3-methylphenyl)acetamides: selective dopamine D4 receptor agonists”. Bioorganic & Medicinal Chemistry. 12 (13): 3471—83. PMID15186832. doi:10.1016/j.bmc.2004.04.035.
^Wang X, Zhong P, Gu Z, Yan Z (2003). „Regulation of NMDA receptors by dopamine D4 signaling in prefrontal cortex”. Journal of Neuroscience. 23 (30): 9852—61. PMID14586014.
^Melis MR, Succu S, Sanna F, Melis T, Mascia MS, Enguehard-Gueiffier C, Hubner H, Gmeiner P, Gueiffier A, Argiolas A (2006). „PIP3EA and PD-168077, two selective dopamine D4 receptor agonists, induce penile erection in male rats: site and mechanism of action in the brain”. The European Journal of Neuroscience. 24 (7): 2021—30. PMID17067298. doi:10.1111/j.1460-9568.2006.05043.x.
^Succu S, Sanna F, Melis T, Boi A, Argiolas A, Melis MR (2007). „Stimulation of dopamine receptors in the paraventricular nucleus of the hypothalamus of male rats induces penile erection and increases extra-cellular dopamine in the nucleus accumbens: Involvement of central oxytocin”. Neuropharmacology. 52 (3): 1034—43. PMID17164075. doi:10.1016/j.neuropharm.2006.10.019.
^Bernaerts P, Tirelli E (2003). „Facilitatory effect of the dopamine D4 receptor agonist PD168,077 on memory consolidation of an inhibitory avoidance learned response in C57BL/6J mice”. Behavioural Brain Research. 142 (1–2): 41—52. PMID12798264. doi:10.1016/S0166-4328(02)00371-6.
