O-774

O-774
IUPAC ime
	7-[(6aR,10aR)-1-hidroksi-6,6,9-trimetil-6a,7,10,10a-tetrahidrobenzo[c]hromen-3-il]-7-metiloktanenitril
Identifikatori
ATC kod	none
PubChem	CID 10833730
ChemSpider	9009030
Hemijski podaci
Formula	C25H35NO2
Molarna masa	381,550 g/mol
	SMILES O3c1cc(C(C)(C)CCCCCC#N)cc(O)c1C2C=C(C)CCC2C3(C)C; ;
	InChI InChI=1S/C25H35NO2/c1-17-10-11-20-19(14-17)23-21(27)15-18(16-22(23)28-25(20,4)5)24(2,3)12-8-6-7-9-13-26/h10,15-16,19-20,27H,6-9,11-12,14H2,1-5H3/t19-,20-/m1/s1 ; Key:RVTLXKSJDYALPU-WOJBJXKFSA-N ;

O-774 je klasični kanabinoidni derivat koji deluje kao potentan agonist za kanabinoidne receptore, sa K_i od 0,6 nM na CB₁, i veoma potentnim kanabinoidnim dejstvom u živitinjskim studijama.^[1]^[2]

Vidi još

O-1057

Reference

^ Singer M, et al. Potent cyano and carboxamido side-chain analogues of 1', 1'-dimethyl-delta8-tetrahydrocannabinol. Journal of Medicinal Chemistry. 1998 Oct 22;41(22):4400-7. PMID 9784115
^ The Cannabinoid Receptors. Part I. Cannabinoid Receptor Ligands and Structure-Activity Relationships. pp. 6-9. Edited by Patricia H Reggio. Humana Press. 2009. ISBN 978-1-58829-712-9.

Spoljašnje veze

[1] Singer M, et al. Potent cyano and carboxamido side-chain analogues of 1', 1'-dimethyl-delta8-tetrahydrocannabinol. Journal of Medicinal Chemistry. 1998 Oct 22;41(22):4400-7. PMID 9784115

[2] The Cannabinoid Receptors. Part I. Cannabinoid Receptor Ligands and Structure-Activity Relationships. pp. 6-9. Edited by Patricia H Reggio. Humana Press. 2009. ISBN 978-1-58829-712-9.

[1]

[2]