MS-245

MS-245
IUPAC ime
	2-[5-metoksi-1-(fenilsulfonil)-1H-indol-3-il]-N,N-dimetiletanamin
Identifikatori
ATC kod	none
PubChem	CID 6918542
Hemijski podaci
Formula	C19H22N2O3S
Molarna masa	358,454 g/mol
	SMILES COc2cc1c(CCN(C)C)cn(c1cc2)S(=O)(=O)c3ccccc3; ;

MS-245 je triptaminski derivat koji se koristi u naučnim istraživanjima. On deluje kao selektivni antagonist 5-HT₆ receptora sa K_i od 2,3 nM. On je izvden putem proučavanja odnosa strukture i aktivnosti selektivnih 5-HT₆ agonista EMDT klase.^[1] On je korišten kao vodeće jedinjenje za dalji razvoj 5-HT₆ antagonista sa triptaminskom osnovom.^[2]^[3]^[4]^[5]

Vidi još

^ Tsai, Y; Dukat, M; Slassi, A; MacLean, N; Demchyshyn, L; Savage, JE; Roth, BL; Hufesein, S; Lee, M (2000). „N1-(Benzenesulfonyl)tryptamines as novel 5-HT6 antagonists”. Bioorganic & Medicinal Chemistry Letters. 10 (20): 2295—9. PMID 11055342. doi:10.1016/S0960-894X(00)00453-4.
^ Abate, C; Kolanos, R; Dukat, M; Setola, V; Roth, BL; Glennon, RA (2005). „Interaction of chiral MS-245 analogs at h5-HT6 receptors”. Bioorganic & Medicinal Chemistry Letters. 15 (15): 3510—3. PMID 15990303. doi:10.1016/j.bmcl.2005.05.092.
^ Dukat, M; Mosier, PD; Kolanos, R; Roth, BL; Glennon, RA (2008). „Binding of serotonin and N1-benzenesulfonyltryptamine-related analogs at human 5-HT6 serotonin receptors: receptor modeling studies”. Journal of Medical Chemistry. 51 (3): 603—11. PMID 15219766. doi:10.1021/jm070910s.
^ Pullagurla, M; Bondareva, T; Young, R; Glennon, RA (2004). „Modulation of the stimulus effects of ( )amphetamine by the 5-HT6 antagonist MS-245”. Pharmacology, Biochemistry, and Behavior. 78 (2): 263—8. PMID 16950502. doi:10.1016/j.pbb.2004.03.017.
^ Young, R; Bondareva, T; Wesolowska, A; Young, S; Glennon, RA (2006). „Effect of the 5-HT(6) serotonin antagonist MS-245 on the actions of (-)nicotine”. Pharmacology, Biochemistry, and Behavior. 85 (1): 170—7. doi:10.1016/j.pbb.2006.07.029.