LIG1
| Ligaza I, DNK, ATP zavisna | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
 | |||||||||||
| Dostupne strukture | |||||||||||
| 1X9N | |||||||||||
| Identifikatori | |||||||||||
| Simboli | LIG1; MGC117397; MGC130025 | ||||||||||
| Vanjski ID | OMIM: 126391 MGI: 101789 HomoloGene: 197 GeneCards: LIG1 Gene | ||||||||||
| EC broj | 6.5.1.1 | ||||||||||
| |||||||||||
| Pregled RNK izražavanja | |||||||||||
 | |||||||||||
| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 3978 | 16881 | |||||||||
| Ensembl | ENSG00000105486 | ENSMUSG00000056394 | |||||||||
| UniProt | P18858 | P37913 | |||||||||
| RefSeq (mRNA) | NM_000234.1 | NM_001083188.1 | |||||||||
| RefSeq (protein) | NP_000225.1 | NP_001076657.1 | |||||||||
| Lokacija (UCSC) |
Chr 19: 48.62 - 48.67 Mb |
Chr 7: 13.86 - 13.9 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
DNK ligaza 1 je enzim koji je kod ljudi kodiran LIG1 genom. On učestvuje u replikaciji DNK i procesu popravke. Mutacije LIG1 koje proizvode deficijenciju DNK ligaze I rezultuju u imunodeficijenciji i povećanoj senzitivnosti na agense koji oštećuju DNK.[1]
Reference
[уреди | уреди извор]Literatura
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