Katepsin B
| Katepsin B | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 | |||||||||
| Identifikatori | |||||||||
| EC broj | 3.4.22.1 | ||||||||
| CAS broj | 9047-22-7 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Katepsin B (EC 3.4.22.1, katepsin B1, katepsin II) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Hidroliza proteina sa širokom specifičšću za peptidne veze. Preferentno dolazi do razlaganja -Arg-Arg- veza u malim molekulskim supstratima (po čeme se razlikuje od katepsina L).
Ovaj intraćelijski (lizozomalni) enzim pripada peptidaznoj familiji C1 (papainskoj familiji)
Reference
[уреди | уреди извор]- ^ Bond, J.S. & Barrett, A.J. (1980). „Degradation of fructose-1,6-bisphosphate aldolase by cathepsin B. A further example of peptidyldipeptidase activity of this proteinase”. Biochem. J. 189: 17—25. PMID 7458901.
- ^ Barrett, A.J. & Kirschke, H. (1981). „Cathepsin B, cathepsin H and cathepsin L”. Methods Enzymol. 80: 535—561. PMID 7043200.
- ^ Polgár, L. and Csoma, C. (1987). „Dissociation of ionizing groups in the binding cleft inversely controls the endo- and exopeptidase activities of cathepsin B”. J. Biol. Chem. 262: 14448—14453. PMID 3312190.
- ^ Barrett, A.J., Buttle, D.J. and Mason, R.W. (1988). „Lysosomal cysteine proteinases”. ISI Atlas of Science. Biochemistry. 1: 256—260.
- ^ Kirschke, H., Wikstrom, P. and Shaw, E. (1988). „Active center differences between cathepsins L and B: the S1 binding region”. FEBS Lett. 228: 128—130. PMID 3342870.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
[уреди | уреди извор]- Cathepsin B на US National Library of Medicine Medical Subject Headings (MeSH)
