GNA12

Guanin nukleotid-vezujući protein (G protein), alfa 12
Guanin nukleotid-vezujući protein (G protein), alfa 12
	PDB prikaz baziran na 1zca.
Dostupne strukture
	1zca
Identifikatori
Simboli	GNA12; RMP; MGC104623; MGC99644; NNX3; gep
Vanjski ID	OMIM: 604394 MGI: 95767 HomoloGene: 22398 GeneCards: GNA12 Gene
Ontologija gena
Molekularna funkcija	• vezivanje nukleotida; • aktivnost GTPaze; • aktivnost prenosnika signala; • vezivanje proteina; • GTP vezivanje; • vezivanje guanil nukleotida;
Celularna komponenta	• heterotrimerni G-proteinski kompleks; • membrana plazme;
Biološki proces	• in utero embrionski razvoj; • prenos signala; • signalni put G-protein spregnutog receptora; • kaskada protein kinaza; • prenos Ro proteinskog signala; • koagulacija krvi; • regulacija ćelijskog oblika; • ćelijska diferencijacija;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	2768
Ensembl	ENSG00000146535
UniProt	Q03113
RefSeq (mRNA)	NM_007353
RefSeq (protein)	NP_031379
Lokacija (UCSC)	Chr 7:; 2.73 - 2.85 Mb
PubMed pretraga	[1]

GNA12, Guanin nukleotid-vezujući protein alfa 12, je protein koji je kod ljudi kodiran GNA12 genom.^[1]^[2]^[3]

Interakcije

Za GNA12 je bilo pokazano da interaguje sa ARHGEF1, PPP5C,^[4] ARHGEF12,^[5]^[6] citosolinim proteinom toplotnog udara 90 kDa alfa, članom A1^[7] i TEC.^[6]

Reference

^ Chan AM; Fleming TP; McGovern ES; Chedid M; Miki T; Stuart A. Aaronson (1993). „Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product”. Mol Cell Biol. 13 (2): 762—8. PMC 358958 . PMID 8423800.
^ Kumar RN, Shore SK, Dhanasekaran N (2006). „Neoplastic transformation by the gep oncogene, Galpha12, involves signaling by STAT3”. Oncogene. 25 (6): 899—906. PMID 16247467. doi:10.1038/sj.onc.1209132.
^ „Entrez Gene: GNA12 guanine nucleotide binding protein (G protein) alpha 12”.
^ Yamaguchi, Yoshiaki; Katoh Hironori; et al. (2002). „Galpha(12) and Galpha(13) interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity”. Curr. Biol. England. 12 (15): 1353—8. ISSN 0960-9822. PMID 12176367. doi:10.1016/S0960-9822(02)01034-5.
^ Fukuhara, S; Chikumi H; Gutkind J S (2000). „Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho”. FEBS Lett. NETHERLANDS. 485 (2-3): 183—8. ISSN 0014-5793. PMID 11094164. doi:10.1016/S0014-5793(00)02224-9.
^ ^а ^б Suzuki, Nobuchika; Nakamura Susumu; et al. (2003). „Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF”. Proc. Natl. Acad. Sci. U.S.A. United States. 100 (2): 733—8. ISSN 0027-8424. PMC 141065 . PMID 12515866. doi:10.1073/pnas.0234057100.
^ Vaiskunaite, R; Kozasa T; Voyno-Yasenetskaya T A (2001). „Interaction between the G alpha subunit of heterotrimeric G(12) protein and Hsp90 is required for G alpha(12) signaling”. J. Biol. Chem. United States. 276 (49): 46088—93. ISSN 0021-9258. PMID 11598136. doi:10.1074/jbc.M108711200.

Vidi još

G12/G13 alfa podjedinice

Spoljašnje veze

GNA12 protein, human на US National Library of Medicine Medical Subject Headings (MeSH)

[pmid8423800-1] Chan AM; Fleming TP; McGovern ES; Chedid M; Miki T; Stuart A. Aaronson (1993). „Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product”. Mol Cell Biol. 13 (2): 762—8. PMC 358958 . PMID 8423800.

[pmid16247467-2] Kumar RN, Shore SK, Dhanasekaran N (2006). „Neoplastic transformation by the gep oncogene, Galpha12, involves signaling by STAT3”. Oncogene. 25 (6): 899—906. PMID 16247467. doi:10.1038/sj.onc.1209132.

[entrez-3] „Entrez Gene: GNA12 guanine nucleotide binding protein (G protein) alpha 12”.

[pmid12176367-4] Yamaguchi, Yoshiaki; Katoh Hironori; et al. (2002). „Galpha(12) and Galpha(13) interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity”. Curr. Biol. England. 12 (15): 1353—8. ISSN 0960-9822. PMID 12176367. doi:10.1016/S0960-9822(02)01034-5.

[pmid11094164-5] Fukuhara, S; Chikumi H; Gutkind J S (2000). „Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho”. FEBS Lett. NETHERLANDS. 485 (2-3): 183—8. ISSN 0014-5793. PMID 11094164. doi:10.1016/S0014-5793(00)02224-9.

[pmid12515866-6] а ^б Suzuki, Nobuchika; Nakamura Susumu; et al. (2003). „Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF”. Proc. Natl. Acad. Sci. U.S.A. United States. 100 (2): 733—8. ISSN 0027-8424. PMC 141065 . PMID 12515866. doi:10.1073/pnas.0234057100.

[pmid11598136-7] Vaiskunaite, R; Kozasa T; Voyno-Yasenetskaya T A (2001). „Interaction between the G alpha subunit of heterotrimeric G(12) protein and Hsp90 is required for G alpha(12) signaling”. J. Biol. Chem. United States. 276 (49): 46088—93. ISSN 0021-9258. PMID 11598136. doi:10.1074/jbc.M108711200.

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