DNK (citozin-5-)-metiltransferaza

Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

DNK (citozin-5-)-metiltransferaza
DNK (citozin-5-)-metiltransferaza
Identifikatori
EC broj	2.1.1.37
CAS broj	9037-42-7
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

DNK (citozin-5-)-metiltransferaza (EC 2.1.1.37, EcoRI metilaza, DNK 5-citozinska metilaza, DNK citozinska C5 metilaza, DNK citozinska metilaza, DNK metilaza, DNK metiltransferaza, DNK transmetilaza, DNK-citozinska 5-metilaza, DNK-citozinska metiltransferaza, HpaII metilaza, HpaII' metilaza, M.BsuRIa, M.BsuRIb, Tip II DNK metilaza, citozinska 5-metiltransferaza, citozinska DNK metilaza, citozinska DNK metiltransferaza, citozin-specifična DNK metiltransferaza, dezoksiribonukleinska metilaza, dezoksiribonukleinska metiltransferaza, dezoksiribonukleinska (citozin-5-)-metiltransferaza, dezoksiribonukleinska kiselina (citozin-5-)-metiltransferaza, dezoksiribonukleinska kiselina metilaza, dezoksiribonukleinska kiselina metiltransferaza, metilaza modifikacije dezoksiribonukleinske kiseline, dezoksiribonukleinska metilaza, metilfosfotriester-DNK metiltransferaza, modifikaciona metilaza, restrikciono-modifikacioni sistem, site-specifična DNK-metiltransferaza (citozin-specifična), DNK-(citozin C5)-metilaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:DNK (citozin-5-)-metiltransferaza.^[1]^[2]^[3]^[4]^[5]^[6]^[7]^[8]^[9] Ovaj enzim katalizuje sledeću hemijsku reakciju

S-adenozil-L-metionin DNK citozin

\rightleftharpoons

S-adenozil-L-homocistein DNK 5-metilcitozin

Reference

^ Gold, M. & Hurwitz, J. (1964). „The enzymatic methylation of ribonucleic acid and deoxyribonucleic acid. V. Purification and properties of the deoxyribonucleic acid-methylating activity of Escherichia coli”. J. Biol. Chem. 239: 3858—2865. PMID 14257620.
^ Kalousek, F. & Morris, N.R. (1969). „The purification and properties of deoxyribonucleic acid methylase from rat spleen”. J. Biol. Chem. 244: 1157—1163. PMID 4975067.
^ Roy, P.H. & Weissbach, A. (1975). „DNA methylase from HeLa cell nuclei”. Nucleic Acids Res. 2: 1669—1684. PMID 1187340.
^ Simon, D., Grunert, F., Acken, U.Y., Döring, H.P. and Kröger, H. (1978). „DNA-methylase from regenerating rat liver: purification and characterisation”. Nucleic Acids Res. 5: 2153—2167. PMID 673848.
^ Sneider, T.W., Teague, W.M. and Rogachewsky, L.M. (1975). „S-Adenosylmethionine: DNA-cytosine 5-methyltransferase from a Novikoff rat hepatoma cell line”. Nucleic Acids Res. 2: 1685—1700. PMID 171625.
^ Turnbull, J.F. & Adams, R.L.P. (1976). „DNA methylase: purification from ascites cells and the effect of various DNA substrates on its activity”. Nucleic Acids Res. 3: 677—695. PMID 131936.
^ Kessler, C. & Manta, V. (1990). „Specificity of restriction endonucleases and DNA modification methyltransferases: a review”. Gene. 92: 1—248. PMID 2172084.
^ Roberts, R.J. (1990). „Restriction enzymes and their isoschizomers”. Nucleic Acids Res. 18: 2331—2365. PMID 2159140.
^ Yuan, R. (1981). „Structure and mechanism of multifunctional restriction endonucleases”. Annu. Rev. Biochem. 50: 285—319. PMID 6267988.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

DNA (cytosine-5-)-methyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Gold, M. & Hurwitz, J. (1964). „The enzymatic methylation of ribonucleic acid and deoxyribonucleic acid. V. Purification and properties of the deoxyribonucleic acid-methylating activity of Escherichia coli”. J. Biol. Chem. 239: 3858—2865. PMID 14257620.

[2] Kalousek, F. & Morris, N.R. (1969). „The purification and properties of deoxyribonucleic acid methylase from rat spleen”. J. Biol. Chem. 244: 1157—1163. PMID 4975067.

[3] Roy, P.H. & Weissbach, A. (1975). „DNA methylase from HeLa cell nuclei”. Nucleic Acids Res. 2: 1669—1684. PMID 1187340.

[4] Simon, D., Grunert, F., Acken, U.Y., Döring, H.P. and Kröger, H. (1978). „DNA-methylase from regenerating rat liver: purification and characterisation”. Nucleic Acids Res. 5: 2153—2167. PMID 673848.

[5] Sneider, T.W., Teague, W.M. and Rogachewsky, L.M. (1975). „S-Adenosylmethionine: DNA-cytosine 5-methyltransferase from a Novikoff rat hepatoma cell line”. Nucleic Acids Res. 2: 1685—1700. PMID 171625.

[6] Turnbull, J.F. & Adams, R.L.P. (1976). „DNA methylase: purification from ascites cells and the effect of various DNA substrates on its activity”. Nucleic Acids Res. 3: 677—695. PMID 131936.

[7] Kessler, C. & Manta, V. (1990). „Specificity of restriction endonucleases and DNA modification methyltransferases: a review”. Gene. 92: 1—248. PMID 2172084.

[8] Roberts, R.J. (1990). „Restriction enzymes and their isoschizomers”. Nucleic Acids Res. 18: 2331—2365. PMID 2159140.

[9] Yuan, R. (1981). „Structure and mechanism of multifunctional restriction endonucleases”. Annu. Rev. Biochem. 50: 285—319. PMID 6267988.

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п р у Enzimi
Teme	Aktivno mesto Alosterna regulacija Mesto vezivanja Katalitički perfektan enzim Koenzim Kofaktor Kooperativnost EC broj Enzimska kataliza Inhibicija enzima Enzimska kinetika Lajnviver—Berkov dijagram Mihaelis—Mentenina kinetika Spisak enzima
Tipovi	EC1 Oksidoreduktaze /spisak EC2 Transferaze /spisak EC3 Hidrolaze /spisak EC4 Lijaze /spisak EC5 Izomeraze /spisak EC6 Ligaze /spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6