CP-809,101

CP-809,101
IUPAC ime
	2-[(3-Hlorofenil)metoksi]-6-(1-piperazinil)pirazin
Identifikatori
CAS broj	479683-64-2
ATC kod	None
Hemijski podaci
Formula	C15H17ClN4O
Molarna masa	304,774 g/mol
	SMILES C2CNCCN2c(n3)cncc3OCc(c1)cccc1Cl; ;

CP-809,101 je lek koji deluje kao potentan i selektivan agonist 5-HT_2C receptora.^[1] On je proizveo obećavajuće rezultate u životinjskim modelima gojaznosti i psihoze, ali isto tako uzrokuje genotoksičnost, te je njegova upotreba ograničena na naučna istraživanja.^[2]^[3]

Reference

^ Strong PV, Greenwood BN, Fleshner M (2009). „The effects of the selective 5-HT(2C) receptor antagonist SB 242084 on learned helplessness in male Fischer 344 rats”. Psychopharmacology. 203 (4): 665—75. PMID 19037632. doi:10.1007/s00213-008-1413-3.
^ Siuciak JA, Chapin DS, McCarthy SA, Guanowsky V, Brown J, Chiang P, Marala R, Patterson T, Seymour PA, Swick A, Iredale PA (2007). „CP-809,101, a selective 5-HT2C agonist, shows activity in animal models of antipsychotic activity”. Neuropharmacology. 52 (2): 279—90. PMID 16949622. doi:10.1016/j.neuropharm.2006.07.024.
^ Kalgutkar AS, Dalvie DK, Aubrecht J, Smith EB, Coffing SL, Cheung JR, Vage C, Lame ME, Chiang P, McClure KF, Maurer TS, Coelho RV, Soliman VF, Schildknegt K (2007). „Genotoxicity of 2-(3-chlorobenzyloxy)-6-(piperazinyl)pyrazine, a novel 5-hydroxytryptamine2c receptor agonist for the treatment of obesity: role of metabolic activation”. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 35 (6): 848—58. PMID 17344339. doi:10.1124/dmd.106.013649.

Spoljašnje veze

[pmid19037632-1] Strong PV, Greenwood BN, Fleshner M (2009). „The effects of the selective 5-HT(2C) receptor antagonist SB 242084 on learned helplessness in male Fischer 344 rats”. Psychopharmacology. 203 (4): 665—75. PMID 19037632. doi:10.1007/s00213-008-1413-3.

[pmid16949622-2] Siuciak JA, Chapin DS, McCarthy SA, Guanowsky V, Brown J, Chiang P, Marala R, Patterson T, Seymour PA, Swick A, Iredale PA (2007). „CP-809,101, a selective 5-HT2C agonist, shows activity in animal models of antipsychotic activity”. Neuropharmacology. 52 (2): 279—90. PMID 16949622. doi:10.1016/j.neuropharm.2006.07.024.

[pmid17344339-3] Kalgutkar AS, Dalvie DK, Aubrecht J, Smith EB, Coffing SL, Cheung JR, Vage C, Lame ME, Chiang P, McClure KF, Maurer TS, Coelho RV, Soliman VF, Schildknegt K (2007). „Genotoxicity of 2-(3-chlorobenzyloxy)-6-(piperazinyl)pyrazine, a novel 5-hydroxytryptamine2c receptor agonist for the treatment of obesity: role of metabolic activation”. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 35 (6): 848—58. PMID 17344339. doi:10.1124/dmd.106.013649.

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