Albendazol

Albendazol
IUPAC ime
	metil N-[6-(propilfulfanil)-1H-1,3-benzodiazol-2-il]karbamat
Klinički podaci
Prodajno ime	Albenza, Eskazole, Valbazen, Zentel
Drugs.com	Monografija
Način primene	Oralno
Farmakokinetički podaci
Poluvreme eliminacije	8 - 12 sati
Izlučivanje	Urinom
Identifikatori
CAS broj	54965-21-8
ATC kod	P02CA03 (WHO)
PubChem	CID 2082
DrugBank	DB00518
ChemSpider	1998
KEGG	C01779
ChEMBL	CHEMBL16664
Hemijski podaci
Formula	C12H15N3O2S
Molarna masa	265.331
	SMILES CCCSC1=CC2=C(C=C1)N=C(NC(=O)OC)N2; ;
	InChI InChI=1S/C12H15N3O2S/c1-3-6-18-8-4-5-9-10(7-8)14-11(13-9)15-12(16)17-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16) ; Key:HXHWSAZORRCQMX-UHFFFAOYSA-N ;
Fizički podaci
Tačka topljenja	209 °C (408 °F)

Albendazol je benzimidazol širokog spektra antihelmintskim dejstvom. On je strukturno srodan sa mebendazolom.^[1]^[2]^[3]^[4]^[5]^[6]

Reference

^ Molina, A. J.; Merino, G.; Prieto, J. G.; Real, R.; Mendoza, G.; Alvarez, A. I. (мај 2007). „Absorption and metabolism of albendazole after intestinal ischemia/Reperfusion”. Eur J Pharm Sci. 31 (1): 16—24. PMID 17350811. doi:10.1016/j.ejps.2007.01.008.
^ Oxberry, M. E.; Reynoldson, J. A.; Thompson, R. C. (јун 2000). „The binding and distribution of albendazole and its principal metabolites in Giardia duodenalis”. J Vet Pharmacol Ther. 23 (3): 113—20. PMID 11110097. doi:10.1046/j.1365-2885.2000.00254.x.
^ Ramirez T, Benitez-Bribiesca L, Ostrosky-Wegman P, Herrera LA (2001 Mar-Apr). „In vitro effects of albendazole and its metabolites on the cell proliferation kinetics and micronuclei frequency of stimulated human lymphocytes”. Arch Med Res. 32 (2): 119—22. PMID 11343808. doi:10.1016/s0188-4409(01)00259-4. Проверите вредност парамет(а)ра за датум: |date= (помоћ)
^ Haque A, Hollister WS, Willcox A, Canning EU (септембар 1993). „The antimicrosporidial activity of albendazole”. J Invertebr Pathol. 62 (2): 171—7. Bibcode:1993JInvP..62..171H. PMID 8228321. doi:10.1006/jipa.1993.1092.
^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.
^ Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (Nucleic Acids Res) (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.

Spoljašnje veze

Albendazole

Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).

[1] Molina, A. J.; Merino, G.; Prieto, J. G.; Real, R.; Mendoza, G.; Alvarez, A. I. (мај 2007). „Absorption and metabolism of albendazole after intestinal ischemia/Reperfusion”. Eur J Pharm Sci. 31 (1): 16—24. PMID 17350811. doi:10.1016/j.ejps.2007.01.008.

[2] Oxberry, M. E.; Reynoldson, J. A.; Thompson, R. C. (јун 2000). „The binding and distribution of albendazole and its principal metabolites in Giardia duodenalis”. J Vet Pharmacol Ther. 23 (3): 113—20. PMID 11110097. doi:10.1046/j.1365-2885.2000.00254.x.

[3] Ramirez T, Benitez-Bribiesca L, Ostrosky-Wegman P, Herrera LA (2001 Mar-Apr). „In vitro effects of albendazole and its metabolites on the cell proliferation kinetics and micronuclei frequency of stimulated human lymphocytes”. Arch Med Res. 32 (2): 119—22. PMID 11343808. doi:10.1016/s0188-4409(01)00259-4. Проверите вредност парамет(а)ра за датум: |date= (помоћ)

[4] Haque A, Hollister WS, Willcox A, Canning EU (септембар 1993). „The antimicrosporidial activity of albendazole”. J Invertebr Pathol. 62 (2): 171—7. Bibcode:1993JInvP..62..171H. PMID 8228321. doi:10.1006/jipa.1993.1092.

[5] Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.

[6] Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (Nucleic Acids Res) (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.

[1]

[2]

[3]

[4]

[5]

[6]