ACPD
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| Nazivi | |
|---|---|
| Sistemski IUPAC naziv
1-Aminociklopentan-1,3-dikarboksilna kiselina[1] | |
| Identifikacija | |
| |
3D model (Jmol)
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| Abrevijacija | ACPD |
| ChemSpider | |
| MeSH | 1-amino-1,3-dicarboxycyclopentane |
| RTECS | GY4060000 (1S,3R) |
| |
| Svojstva | |
| C7H11NO4 | |
| Molarna masa | 173,17 g·mol−1 |
| Agregatno stanje | Beli kristali |
| 20 g dm-3 | |
| Rastvorljivost u etanol | 240 mg dm-3 |
| log P | -0,709 |
| Kiselost (pKa) | 2,112 |
| Baznost (pKb) | 11,885 |
| Izoelektrična tačka | 2,84 |
| Opasnosti | |
| GHS grafikoni | 
|
| GHS signalna reč | Warning |
| H302, H312, H315, H319, H332, H335 | |
| P261, P280, P305 351 338 | |
EU klasifikacija (DSD)
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 Xn
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| R-oznake | R20/21/22, R36/37/38 |
| S-oznake | S26, S36/37 |
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa). | |
 verifikuj (šta je   ?)
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| Reference infokutije | |
1-Amino-1,3-dikarboksiciklopentan (ACPD) je hemijsko jedinjenje koje se vezuje za metabotropni glutamatni receptor (mGluR).[4] ACPD deluje kao mGluR agonist. On je krut analog neurotransmitera glutamata koji ne aktivira jonotropne glutamatne receptore.[5] ACPD može da indukuje konvulzije kod neonatalnih pacova.[6]
Reference
[уреди | уреди извор]- ^ „1-amino-1,3-dicarboxycyclopentane - Compound Summary”. PubChem Compound. USA: National Center for Biotechnology Information. 25. 3. 2005. Identification and Related Records. Приступљено 15. 10. 2011.
- ^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.
- ^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
- ^ Schoepp DD, True RA (1992). „1S,3R-ACPD-sensitive (metabotropic) [3H]glutamate receptor binding in membranes”. Neurosci. Lett. 145 (1): 100—4. PMID 1461560. doi:10.1016/0304-3940(92)90213-Q.
- ^ Manzoni O, Fagni L, Pin JP, Rassendren F, Poulat F, Sladeczek F, Bockaert J (1990). „(trans)-1-amino-cyclopentyl-1,3-dicarboxylate stimulates quisqualate phosphoinositide-coupled receptors but not ionotropic glutamate receptors in striatal neurons and Xenopus oocytes”. Mol. Pharmacol. 38 (1): 1—6. PMID 2164627.
- ^ McDonald JW, Fix AS, Tizzano JP, Schoepp DD (1993). „Seizures and brain injury in neonatal rats induced by 1S,3R-ACPD, a metabotropic glutamate receptor agonist”. J. Neurosci. 13 (10): 4445—55. PMID 8410197.
