Фруктоза-бисфосфат алдолаза
Изглед
Fruktoza-bisfosfat aldolaza | |||||||||
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Identifikatori | |||||||||
EC broj | 4.1.2.13 | ||||||||
CAS broj | 9024-52-6 | ||||||||
Baze podataka | |||||||||
IntEnz | IntEnz pregled | ||||||||
BRENDA | BRENDA pristup | ||||||||
ExPASy | NiceZyme pregled | ||||||||
KEGG | KEGG pristup | ||||||||
MetaCyc | metabolički put | ||||||||
PRIAM | profil | ||||||||
Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
Ontologija gena | AmiGO / EGO | ||||||||
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Fruktoza-bisfosfat aldolaza (EC 4.1.2.13, aldolaza) je enzim koji katalizuje reverzibilnu reakciju kojom se razlaže aldol, fruktoza 1,6-bisfosfat, u triozne fosfate dihidroksiaceton fosfat (DHAP) i gliceraldehid 3-fosfat (GAP). Aldolaza takođe može da proizvede DHAP iz drugih (3S,4R)-ketoza 1-fosfata kao što su fruktoza 1-fosfat i sedoheptuloza 1,7-bisfosfat. Glukoneogeneza i Kalvinov ciklus, koji su anabolički putevi, te koriste reverznu reakciju. Glikoliza, katabolički put, koristi reakciju unapred. Aldolaze se dele u dve klase po mehanizmu.
Literatura
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. PMID 3355497.
- Galkin A, Li Z, Li L, Kulakova L, Pal LR, Dunaway-Mariano D, Herzberg O (2009). „Structural insights into the substrate binding and stereoselectivity of giardia fructose-1,6-bisphosphate aldolase”. Biochemistry. 48 (14): 3186—96. PMC 2666783
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