FZD6

Uvojiti receptor 6
Uvojiti receptor 6
Identifikatori
Simboli	FZD6; FZ-6; FZ6; HFZ6; NDNC10
Vanjski ID	OMIM: 603409 MGI: 108474 HomoloGene: 2617 IUPHAR: FZD6 GeneCards: FZD6 Gene
Ontologija gena
Molekularna funkcija	• aktivnost G protein spregnutog receptora; • receptorsko vezivanje; • proteinsko vezivanje; • Wnt proteinsko vezivanje;
Celularna komponenta	• citoplazma; • ćelijska površina; • integralno sa membranom; • sinaptosom; • membrana neuronske projekcije;
Biološki proces	• pozitivna regulacija proteinske fosforilacije; • razvoj vaskulature; • morfogeneza odlivnog trakta; • signalni put G protein spregnutog receptora spregnutog sa cGMP nukleotidom;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	8323
Ensembl	ENSG00000164930
UniProt	B4DRN0
RefSeq (mRNA)	NM_001164615.1
RefSeq (protein)	NP_001158087.1
Lokacija (UCSC)	Chr 8:; 104.31 - 104.35 Mb
PubMed pretraga	[1]

Uvojiti-6 je protein koji je kod ljudi kodiran FZD6 genom.^[1]^[2]^[3]

Članovi familije „uvojitih“ proteina su 7-transmembranski receptori za Wnt signalne proteine. FZD6 protein sadrži signalni peptid, cisteinom bogati domen u N-terminalnom ekstracelularnom regionu i 7 transmembranski domen. Za razliku od mnogih drugih članova FZD familije, FDZ6 ne sadrži C-terminalni PDZ vezujući motif.^[3] Postoje indikacije da je FZD6 protein receptor za WNT4 ligand.^[4]

Interakcije

FZD6 formira interakcije sa SFRP1.^[5]

Reference

^ Tokuhara M, Hirai M, Atomi Y, Terada M, Katoh M (1998). „Molecular cloning of human Frizzled-6”. Biochem Biophys Res Commun. 243 (2): 622—7. PMID 9480858. doi:10.1006/bbrc.1998.8143.
^ Golan T, Yaniv A, Bafico A, Liu G, Gazit A (2004). „The human Frizzled 6 (HFz6) acts as a negative regulator of the canonical Wnt. beta-catenin signaling cascade”. J Biol Chem. 279 (15): 14879—88. PMID 14747478. doi:10.1074/jbc.M306421200.
^ ^а ^б „Entrez Gene: FZD6 frizzled homolog 6 (Drosophila)”.
^ Lyons JP, Mueller UW, Ji H, Everett C, Fang X, Hsieh JC, Barth AM, McCrea PD (2004). „WNT4 activates the canonical beta-catenin-mediated WNT pathway and binds FZD6 CRD: functional implications of Wnt/beta-catenin activity in kidney epithelial cells.”. Experimental Cell Research. 298 (2): 369—387. PMID 15265686. doi:10.1016/j.yexcr.2004.04.036.
^ Bafico, A; Gazit A (1999). „Interaction of frizzled related protein (FRP) with WNT ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of WNT signaling”. J. Biol. Chem. UNITED STATES. 274 (23): 16180—7. ISSN 0021-9258. PMID 10347172. doi:10.1074/jbc.274.23.16180.

Literatura

Wang Y; Macke JP; Abella BS (1996). „A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled.”. J. Biol. Chem. 271 (8): 4468—76. PMID 8626800. doi:10.1074/jbc.271.8.4468.
Finch PW; He X; Kelley MJ (1997). „Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action.”. Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770—5. PMC 21233 . PMID 9192640. doi:10.1073/pnas.94.13.6770.
Bafico A; Gazit A; Pramila T (1999). „Interaction of frizzled related protein (FRP) with WNT ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling.”. J. Biol. Chem. 274 (23): 16180—7. PMID 10347172. doi:10.1074/jbc.274.23.16180.
Strausberg RL; Feingold EA; Grouse LH (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Omoto S; Hayashi T; Kitahara K (2004). „Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R).”. Ophthalmic Genet. 25 (2): 81—90. PMID 15370539. doi:10.1080/13816810490514270.
Gerhard DS; Wagner L; Feingold EA (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Kimura K; Wakamatsu A; Suzuki Y (2006). „Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.”. Genome Res. 16 (1): 55—65. PMC 1356129 . PMID 16344560. doi:10.1101/gr.4039406.
Sirchia R, Luparello C (2007). „Mid-region parathyroid hormone-related protein (PTHrP) and gene expression of MDA-MB231 breast cancer cells.”. Biol. Chem. 388 (5): 457—65. PMID 17516841. doi:10.1515/BC.2007.059.

Vidi još

Uvojiti receptori

Spoljašnje veze

„Frizzled Receptors: FZD₆”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 24. 01. 2016. г.

[pmid9480858-1] Tokuhara M, Hirai M, Atomi Y, Terada M, Katoh M (1998). „Molecular cloning of human Frizzled-6”. Biochem Biophys Res Commun. 243 (2): 622—7. PMID 9480858. doi:10.1006/bbrc.1998.8143.

[pmid14747478-2] Golan T, Yaniv A, Bafico A, Liu G, Gazit A (2004). „The human Frizzled 6 (HFz6) acts as a negative regulator of the canonical Wnt. beta-catenin signaling cascade”. J Biol Chem. 279 (15): 14879—88. PMID 14747478. doi:10.1074/jbc.M306421200.

[entrez-3] а ^б „Entrez Gene: FZD6 frizzled homolog 6 (Drosophila)”.

[pmid15265686-4] Lyons JP, Mueller UW, Ji H, Everett C, Fang X, Hsieh JC, Barth AM, McCrea PD (2004). „WNT4 activates the canonical beta-catenin-mediated WNT pathway and binds FZD6 CRD: functional implications of Wnt/beta-catenin activity in kidney epithelial cells.”. Experimental Cell Research. 298 (2): 369—387. PMID 15265686. doi:10.1016/j.yexcr.2004.04.036.

[pmid10347172-5] Bafico, A; Gazit A (1999). „Interaction of frizzled related protein (FRP) with WNT ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of WNT signaling”. J. Biol. Chem. UNITED STATES. 274 (23): 16180—7. ISSN 0021-9258. PMID 10347172. doi:10.1074/jbc.274.23.16180.

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