Azoximer bromide

Azoximer bromide
Clinical data
Synonyms	Polyoxidonium, Synpol
ATC code	L03AX (WHO) ;
Pharmacokinetic data
Bioavailability	up to 89%
Elimination half-life	25.4 hours (intravenous routes)
Identifiers
	IUPAC name Poly[[1-(carboxymethyl)piperazin-1-ium-1,4-diyl bromide]ethylene- co-[(piperazin-1,4-diyl 1-oxide)ethylene]];
CAS Number	892497-01-7;
ChemSpider	none;
Chemical and physical data
Formula	[[C8H15BrN2O2]x[C6H12N2O]y]n
Molar mass	60000–100000 g/mol

Azoximer bromide is a macromolecular compound with high-molecular weight and not proved immunomodulating activity. It is using in CIS countries for treatment and prophylaxis of diseases connected with damage of immune system. It is a N-oxidized polyethylene–piperazine derivative. Azoximer bromide is sold under the trade name Polyoxidonium.

Polyoxidonium is registered in US Patent-5503830 from 1996,^[1]^[2]^[3] in the Russian Federation from 1996, under registration number 96/302/9, FS 42-3906-00.^[4]

References

↑ http://www.google.com/patents/about?id=s9cfAAAAEBAJ&dq=US 5503830
↑ http://www.wikipatents.com/US-Patent-5503830/compounds-having-immunostimulating-activity-and-methods-of-use-thereof^{[permanent dead link]}
↑ "Compounds for the Prevention and Treatment of Helminth Infections".
↑ State Scientific Centre of Russian federation, Immunological Institute of Russian Federation Health Resort, CLINICAL ASPECTS OF USE OF IMMUNOMODULATOR POLYOXIDONIUM, Methodical handbook for doctors issued by State Scientific Centre of Russian Federation – Immunological Institute of Russian Federation Health Resort Moscow – 2003

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[1] ttp://www.google.com/patents/about?id=s9cfAAAAEBAJ&dq=US 5503830

[2] ttp://www.wikipatents.com/US-Patent-5503830/compounds-having-immunostimulating-activity-and-methods-of-use-thereof^{[permanent dead link]}

[3] "Compounds for the Prevention and Treatment of Helminth Infections".

[4] State Scientific Centre of Russian federation, Immunological Institute of Russian Federation Health Resort, CLINICAL ASPECTS OF USE OF IMMUNOMODULATOR POLYOXIDONIUM, Methodical handbook for doctors issued by State Scientific Centre of Russian Federation – Immunological Institute of Russian Federation Health Resort Moscow – 2003

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