Allopurinol
medication to decrease high blood uric acid levels
Allopurinol (brand names Zyloprim, Caplenal, Zyloric) is a medication used to treat high blood uric acid (hyperuricemia) by making the level of uric acid in the blood lower.[1] It is specifically used to prevent gout,[2] preventing specific types of kidney stones, and for the high uric acid levels that can occur with chemotherapy.[3][4] It is taken orally (by mouth) or intravenously (injected into a vein).
Allopurinol was approved for medical use in the United States in 1966.[4] It is on the World Health Organization's List of Essential Medicines.[5] Allopurinol is available as a generic medication.[4] In 2022, it was the 39th most commonly prescribed medication in the United States, with more than 15 million prescriptions.[6][7]
References
change- ↑ Pacher P, Nivorozhkin A, Szabó C (March 2006). "Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol". Pharmacological Reviews. 58 (1): 87–114. doi:10.1124/pr.58.1.6. PMC 2233605. PMID 16507884.
- ↑ https://www.ncbi.nlm.nih.gov/books/NBK499942/#article-17382.s2
- ↑ World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 39. hdl:10665/44053. ISBN 9789241547659.
- ↑ 4.0 4.1 4.2 Cite error: The named reference
AHFS2016was used but no text was provided for refs named (see the help page). - ↑ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
- ↑ "The Top 300 of 2022". ClinCalc. Archived from the original on 30 August 2024. Retrieved 30 August 2024.
- ↑ "Allopurinol Drug Usage Statistics, United States, 2013 - 2022". ClinCalc. Retrieved 30 August 2024.