TAS2R16
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| Receptor ukusa tip 2 član 16 | |||||||||||
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| Identifikatori | |||||||||||
| Simboli | TAS2R16; T2R16 | ||||||||||
| Vanjski ID | OMIM: 604867 MGI: 2681247 HomoloGene: 9660 IUPHAR: GeneCards: TAS2R16 Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 50833 | 387347 | |||||||||
| Ensembl | ENSG00000128519 | ENSMUSG00000043865 | |||||||||
| UniProt | Q9NYV7 | P59529 | |||||||||
| RefSeq (mRNA) | NM_016945.2 | NM_207022.1 | |||||||||
| RefSeq (protein) | NP_058641.1 | NP_996905.1 | |||||||||
| Lokacija (UCSC) | Chr 7: 122.63 - 122.64 Mb | Chr 6: 23.92 - 23.92 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Receptor ukusa tip 2 član 16 je protein koji je kod ljudi kodiran TAS2R16 genom.[1][2]
Varijante ovog gena su povezane sa povećanim rizikom od alkoholne zavisnosti.[3]
TAS2R16 gen je lociran na dugačkoj (q) ruci hromozoma 7 u poziciji 31.1 - 31.3, od baznog para 122.228.764 do baznog para 122.229.639.
- ↑ Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W (2002). „The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides”. Nat Genet 32 (3): 397–401. DOI:10.1038/ng1014. PMID 12379855.
- ↑ Drewnowski A (2001). „The science and complexity of bitter taste”. Nutr Rev 59 (6): 163–9. DOI:10.1111/j.1753-4887.2001.tb07007.x. PMID 11444592.
- ↑ Hinrichs AL, Wang JC, Bufe B, et al. (2006). „Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence”. Am. J. Hum. Genet. 78 (1): 103–11. DOI:10.1086/499253. PMC 1380207. PMID 16385453.
- Kinnamon SC (2000). „A plethora of taste receptors.”. Neuron 25 (3): 507–10. DOI:10.1016/S0896-6273(00)81054-5. PMID 10774719.
- Margolskee RF (2002). „Molecular mechanisms of bitter and sweet taste transduction.”. J. Biol. Chem. 277 (1): 1–4. DOI:10.1074/jbc.R100054200. PMID 11696554.
- Montmayeur JP, Matsunami H (2002). „Receptors for bitter and sweet taste.”. Curr. Opin. Neurobiol. 12 (4): 366–71. DOI:10.1016/S0959-4388(02)00345-8. PMID 12139982.
- Adler E, Hoon MA, Mueller KL, et al. (2000). „A novel family of mammalian taste receptors.”. Cell 100 (6): 693–702. DOI:10.1016/S0092-8674(00)80705-9. PMID 10761934.
- Chandrashekar J, Mueller KL, Hoon MA, et al. (2000). „T2Rs function as bitter taste receptors.”. Cell 100 (6): 703–11. DOI:10.1016/S0092-8674(00)80706-0. PMID 10761935.
- Firestein S (2000). „The good taste of genomics.”. Nature 404 (6778): 552–3. DOI:10.1038/35007167. PMID 10766221.
- Matsunami H, Montmayeur JP, Buck LB (2000). „A family of candidate taste receptors in human and mouse.”. Nature 404 (6778): 601–4. DOI:10.1038/35007072. PMID 10766242.
- Bufe B, Hofmann T, Krautwurst D, et al. (2002). „The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides.”. Nat. Genet. 32 (3): 397–401. DOI:10.1038/ng1014. PMID 12379855.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Zhang Y, Hoon MA, Chandrashekar J, et al. (2003). „Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.”. Cell 112 (3): 293–301. DOI:10.1016/S0092-8674(03)00071-0. PMID 12581520.
- Hillier LW, Fulton RS, Fulton LA, et al. (2003). „The DNA sequence of human chromosome 7.”. Nature 424 (6945): 157–64. DOI:10.1038/nature01782. PMID 12853948.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Fischer A, Gilad Y, Man O, Pääbo S (2005). „Evolution of bitter taste receptors in humans and apes.”. Mol. Biol. Evol. 22 (3): 432–6. DOI:10.1093/molbev/msi027. PMID 15496549.
- Go Y, Satta Y, Takenaka O, Takahata N (2006). „Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates.”. Genetics 170 (1): 313–26. DOI:10.1534/genetics.104.037523. PMC 1449719. PMID 15744053.
- Mueller KL, Hoon MA, Erlenbach I, et al. (2005). „The receptors and coding logic for bitter taste.”. Nature 434 (7030): 225–9. DOI:10.1038/nature03352. PMID 15759003.
- Hinrichs AL, Wang JC, Bufe B, et al. (2006). „Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence.”. Am. J. Hum. Genet. 78 (1): 103–11. DOI:10.1086/499253. PMC 1380207. PMID 16385453.
- Behrens M, Bartelt J, Reichling C, et al. (2006). „Members of RTP and REEP gene families influence functional bitter taste receptor expression.”. J. Biol. Chem. 281 (29): 20650–9. DOI:10.1074/jbc.M513637200. PMID 16720576.