Neoflavonoid

Neoflavonoidi su klasa polifenolnih jedinjenja^[1]. Flavonoidi (u užem smislu) imaju 2-fenilhromen-4-on osnovu, dok neoflavonoidi imaju 4-fenilhromensku osnovu bez hidroksilne supstitucije u poziciji 2.

Tipovi

Hemijska struktura 4-fenilkumarina (neoflavonska osnova).

Neoflavonoidi obuhvataju 4-arilkumarin (neoflavon), 4-arilhroman, dalbergion i dalbergihinol.

Neoflavoni^[2] su izvedeni iz 4-fenilkumarinske (ili 4-Aril-kumarinske) osnove (C₁₅H₁₂O₂, molarna masa : 224.25 g/mol)^[3]. Prvi neoflavon je izolovan iz prirodnih izvora 1951. To je bio kalofilolid iz Calophyllum inophyllum semena^[4].

Neoflaveni poseduju 4-fenilhromensku osnovu (hemijska formula: C₁₅H₁₀O₂, masa: 222.068). Dalbergihromen, koji je ekstrahovan iz drveta Dalbergia sissoo je primer takvog jedinjenja.^[5]

Reference

[1] The neoflavanoids, a new class of natural products. Cellular and Molecular Life Sciences, Volume 22, Number 12 / december 1966^{[mrtav link]}

[2] Revised structure of neoflavone in Coutarea hexandra. Munekazu Iinuma, Toshiyuki Tanaka, Koji Hamada, Mizuo Mizuno, Fujio Asai, Gesa Reher and Ljubomir Kraus, Phytochemistry, Volume 26, Issue 11, 1987, Pages 3096-3097.

[3] Structures of 4-Aryl-coumarin (Neoflavone) Dimers Isolated from Pistacia chinensis BUNGE and Their Estrogen-like Activity. Satoshi NISHIMURA, Motohiko TAKI, Sachiko TAKAISHI, Yasuteru IIJIMA and Toshiyuki AKIYAMA, Chem. Pharm. Bull. 48(4) 505—508 (2000)

[4] Neoflavones. 1. Natural Distribution and Spectral and Biological Properties. M. M. Garazd, Ya. L. Garazd and V. P. Khilya, Chemistry of Natural Compounds, Volume 39, Number 1 / janvier 2003.^{[mrtav link]}

[5] Dalbergichromene : A new neoflavonoid from stem-bark and heartwood of Dalbergia sissoo. Mukerjee S. K., Saroja T. and SeshadriT. R., Tetrahedron, Volume 27, Issue 4, 1971, Pages 799-803

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