N-acetillaktozaminid b-1,3-N-acetilglukozaminiltransferaza
| N-acetillaktozaminid b-1,3-N-acetilglukozaminiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.1.149 | ||||||||
| CAS broj | 85638-39-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
N-acetillaktozaminid b-1,3-N-acetilglukozaminiltransferaza (EC 2.4.1.149, uridin difosfoacetilglukozamin-acetillaktozaminid beta1->3-acetilglukozaminiltransferaza, poli-N-acetillaktozaminski enzim produžavanja, Galbeta1->4GlcNAc-R beta1->3 N-acetilglukozaminiltransferaza, UDP-GlcNAc:GalR, beta-D-3-N-acetilglukozaminiltransferaza, N-acetillaktozamin beta(1-3)N-acetilglukozaminiltransferaza, UDP-GlcNAc:Galbeta1->4GlcNAcbeta-Rbeta1->3-N-acetilglukozaminiltransferaza, GnTE, UDP-N-acetil-D-glukozamin:beta-D-galaktozil-1,4-N-acetil-D-glukozamin beta-1,3-acetil-D-glukozaminiltransferaza) je enzim sa sistematskim imenom UDP-N-acetil-D-glukozamin:beta-D-galaktozil-(1->4)-N-acetil-D-glukozamin 3-beta-N-acetil-D-glukozaminiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- UDP-N-acetil-D-glukozamin beta-D-galaktozil-(1->4)-N-acetil-D-glukozaminil-R UDP N-acetil-beta-D-glukozaminil-(1->3)-beta-D-galaktozil-(1->4)-N-acetil-D-glukozaminil-R
Ovaj enzim deluje na beta-galaktozil-1,4-N-acetilglukozaminil terminus na asijalo-alfa1-kiselinskom glikoproteinu i drugim glikoproteinima i oligosaharidima.
- ↑ Takeya, A., Hosomi, O. and Kogure, T. (1985). „The presence of N-acetyllactosamine and lactose: β (1-3)N-acetylglucosaminyltransferase activity in human urine”. Jpn. J. Med. Sci. Biol. 38: 1-8. PMID 3160874.
- ↑ Van den Eijnden, D.H., Winterwerp, H., Smeeman, P. and Schiphorst, W.E.C.M. (1983). „Novikoff ascites tumor cells contain N-acetyllactosaminide β1⊟3 and β1⊟6 N-acetylglucosaminyltransferase activity”. J. Biol. Chem. 258: 3435-3437. PMID 6219989.
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