Levonorgestrel
(IUPAC ) ime
(–)-13-etil-17-etinil-17-hidroksi- 1,2,6,7,8,9,10,11,12,13,14,15,16, 17- tetradekahidrociklopenta[a] fenantren-3-on
Klinički podaci
Robne marke
Norplant
MedlinePlus
a610021
Identifikatori
CAS broj
797-63-7
ATC kod
G03 AC03 G03 AD01
PubChem [ 1] [ 2] 13109
DrugBank
DB00367
ChemSpider [ 3] 12560
UNII
5W7SIA7YZW Y
KEGG [ 4] D00950 Y
ChEBI
CHEBI:6443 Y
ChEMBL [ 5] CHEMBL1389 Y
Hemijski podaci
Formula
C 21 H 28 O 2
Mol. masa
312,446 g/mol
SMILES
eMolekuli PubHem
InChI InChI=1S/C21H28O2/c1-3-20-11-9-17-16-8-6-15(22)13-14(16)5-7-18(17)19(20)10-12-21(20,23)4-2/h2,13,16-19,23H,3,5-12H2,1H3/t16-,17 ,18 ,19-,20-,21-/m0/s1 Y Y
Farmakokinetički podaci
Bioraspoloživost
~100%
Vezivanje za proteine plazme
55%
Metabolizam
Hepatički putem CYP3A4
Poluvreme eliminacije
36 ± 13 h
Izlučivanje
Renal : 45%; Fekalno :32%
Farmakoinformacioni podaci
Trudnoća
?
Pravni status
Rx-OTC
Način primene
Implant, oralno
Levonorgestrel (L -norgestrel D -norgestrel[ 6] progestogena . On se koristi kao aktivni sastojaku u pojedinim hormonalnim kontraceptivima , uključujući kombinovane oralne kontraceptivne pilule , pilule progestogena , pilule za hitnu kontracepciju , intrauterinske sisteme , kontraceptivne implante, i terapiju hormonske zamene .
↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.” . Drug Discov Today 15 (23-24): 1052-7. DOI :10.1016/j.drudis.2010.10.003 . PMID 20970519 . edit ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4 : 217-241. DOI :10.1016/S1574-1400(08)00012-1 . ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining” . J Cheminform 2 (1): 3. DOI :10.1186/1758-2946-2-3 . PMID 20331846 . edit ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG” . Yeast 17 (1): 48–55. DOI :10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H . ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI :10.1093/nar/gkr777 . PMID 21948863 . edit ↑ „Oral contraceptives that can be used for emergency contraception” . Arhivirano iz originala na datum 2009-05-03. Pristupljeno 2014-04-05 .
