GNA12

Guanin nukleotid-vezujući protein (G protein), alfa 12
	; PDB prikaz baziran na 1zca.
Dostupne strukture
	1zca
Identifikatori
Simboli	GNA12; RMP; MGC104623; MGC99644; NNX3; gep
Vanjski ID	OMIM: 604394 MGI: 95767 HomoloGene: 22398 GeneCards: GNA12 Gene
Ontologija gena
Molekularna funkcija	• vezivanje nukleotida; • aktivnost GTPaze; • aktivnost prenosnika signala; • vezivanje proteina; • GTP vezivanje; • vezivanje guanil nukleotida;
Celularna komponenta	• heterotrimerni G-proteinski kompleks; • membrana plazme;
Biološki proces	• in utero embrionski razvoj; • prenos signala; • signalni put G-protein spregnutog receptora; • kaskada protein kinaza; • prenos Ro proteinskog signala; • koagulacija krvi; • regulacija ćelijskog oblika; • ćelijska diferencijacija;
Pregled RNK izražavanja
	podaci
Ortolozi

edit

GNA12, Guanin nukleotid-vezujući protein alfa 12, je protein koji je kod ljudi kodiran GNA12 genom.^[1]^[2]^[3]

Interakcije

Za GNA12 je bilo pokazano da interaguje sa ARHGEF1, PPP5C,^[4] ARHGEF12,^[5]^[6] citosolinim proteinom toplotnog udara 90 kDa alfa, članom A1^[7] i TEC.^[6]

Reference

↑ Chan AM, Fleming TP, McGovern ES, Chedid M, Miki T, Stuart A. Aaronson (Feb 1993). „Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product”. Mol Cell Biol 13 (2): 762–8. PMC 358958. PMID 8423800.
↑ Kumar RN, Shore SK, Dhanasekaran N (Feb 2006). „Neoplastic transformation by the gep oncogene, Galpha12, involves signaling by STAT3”. Oncogene 25 (6): 899–906. DOI:10.1038/sj.onc.1209132. PMID 16247467.
↑ „Entrez Gene: GNA12 guanine nucleotide binding protein (G protein) alpha 12”.
↑ Yamaguchi, Yoshiaki; Katoh Hironori, Mori Kazutoshi, Negishi Manabu (August 2002). „Galpha(12) and Galpha(13) interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity”. Curr. Biol. (England) 12 (15): 1353–8. DOI:10.1016/S0960-9822(02)01034-5. ISSN 0960-9822. PMID 12176367.
↑ Fukuhara, S; Chikumi H, Gutkind J S (November 2000). „Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho”. FEBS Lett. (NETHERLANDS) 485 (2-3): 183–8. DOI:10.1016/S0014-5793(00)02224-9. ISSN 0014-5793. PMID 11094164.
↑ ^6,0 ^6,1 Suzuki, Nobuchika; Nakamura Susumu, Mano Hiroyuki, Kozasa Tohru (January 2003). „Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF”. Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (2): 733–8. DOI:10.1073/pnas.0234057100. ISSN 0027-8424. PMC 141065. PMID 12515866.
↑ Vaiskunaite, R; Kozasa T, Voyno-Yasenetskaya T A (December 2001). „Interaction between the G alpha subunit of heterotrimeric G(12) protein and Hsp90 is required for G alpha(12) signaling”. J. Biol. Chem. (United States) 276 (49): 46088–93. DOI:10.1074/jbc.M108711200. ISSN 0021-9258. PMID 11598136.

Povezano

G12/G13 alfa podjedinice

Spoljašnje veze

MeSH GNA12 protein, human

[pmid8423800-1] Chan AM, Fleming TP, McGovern ES, Chedid M, Miki T, Stuart A. Aaronson (Feb 1993). „Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product”. Mol Cell Biol 13 (2): 762–8. PMC 358958. PMID 8423800.

[pmid16247467-2] Kumar RN, Shore SK, Dhanasekaran N (Feb 2006). „Neoplastic transformation by the gep oncogene, Galpha12, involves signaling by STAT3”. Oncogene 25 (6): 899–906. DOI:10.1038/sj.onc.1209132. PMID 16247467.

[entrez-3] „Entrez Gene: GNA12 guanine nucleotide binding protein (G protein) alpha 12”.

[pmid12176367-4] Yamaguchi, Yoshiaki; Katoh Hironori, Mori Kazutoshi, Negishi Manabu (August 2002). „Galpha(12) and Galpha(13) interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity”. Curr. Biol. (England) 12 (15): 1353–8. DOI:10.1016/S0960-9822(02)01034-5. ISSN 0960-9822. PMID 12176367.

[pmid11094164-5] Fukuhara, S; Chikumi H, Gutkind J S (November 2000). „Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho”. FEBS Lett. (NETHERLANDS) 485 (2-3): 183–8. DOI:10.1016/S0014-5793(00)02224-9. ISSN 0014-5793. PMID 11094164.

[pmid12515866-6] 6,0 ^6,1 Suzuki, Nobuchika; Nakamura Susumu, Mano Hiroyuki, Kozasa Tohru (January 2003). „Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF”. Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (2): 733–8. DOI:10.1073/pnas.0234057100. ISSN 0027-8424. PMC 141065. PMID 12515866.

[pmid11598136-7] Vaiskunaite, R; Kozasa T, Voyno-Yasenetskaya T A (December 2001). „Interaction between the G alpha subunit of heterotrimeric G(12) protein and Hsp90 is required for G alpha(12) signaling”. J. Biol. Chem. (United States) 276 (49): 46088–93. DOI:10.1074/jbc.M108711200. ISSN 0021-9258. PMID 11598136.

[1]

[2]

[3]

[4]

[5]

[6]

[7]