Etilefrin

Etilefrin
(IUPAC) ime
	(RS)-3-[2-(ethylamino)-1-hydroxyethyl]phenol
Klinički podaci
Identifikatori
CAS broj	709-55-7
ATC kod	C01CA01
PubChem	3306
ChemSpider	3190
KEGG	D07931
ChEMBL	CHEMBL86882
Hemijski podaci
Formula	C10H15NO2
Mol. masa	181.232 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C10H15NO2/c1-2-11-7-10(13)8-4-3-5-9(12)6-8/h3-6,10-13H,2,7H2,1H3 ; Key: SQVIAVUSQAWMKL-UHFFFAOYSA-N
Sinonimi	(2-ethylamino-1-(3'-hydroxy-phenyl)ethanol
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

Etilefrin je srčani stimulant koji se koristi kao antihipotenziv. On je simpatomimetički amin iz 3-hidroksi-feniletanolaminske serije koji se koristi za lečenje ortostatske hipotenzije neurološkog, kardiovaslularnog, endokrinog ili metaboličkog porekla. Intravenozna infuzija ovog leka povećava srčani učinak, udarni volumen, venski povratak i krvni pritisak kod ljudi i eksperimentalnih životinja. Iz toga proizilazi da on stimuliše α i β adrenergičke receptore.^[6] Međutim, in vitro studije indiciraju da etilefrin ima mnogo veći afinitet za β₁ (srčane) nego za β₂ adrenoreceptore.^[7]

Intravenozni etilefrin ubrzava puls, uvećava srčani izlaz, udarni volumen, centralni venski i srednji arterijski pritisak zdravih osoba. Periferni vaskularni otpor opada tokom infuzije 1–8 mg etilefrina ali počinje da raste na višim dozama

Literatura

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948863. edit
↑ Nusser, Donath and Russ, 1965; Mellander, 1966; Limbourg, Just and Lang, 1973; Tarnow et al.~1973; Carrera and Aguilera, 1973
↑ Offermeier and Dreyer, 1971

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948863. edit

[6] Nusser, Donath and Russ, 1965; Mellander, 1966; Limbourg, Just and Lang, 1973; Tarnow et al.~1973; Carrera and Aguilera, 1973

[7] Offermeier and Dreyer, 1971

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