Detomidin

Detomidin
(IUPAC) ime
	4-[(2,3-dimetilfenil)metil]-3H-imidazol
Klinički podaci
AHFS/Drugs.com	Internacionalno ime leka
Identifikatori
CAS broj	86347-15-1
ATCvet kod	QN05CM90
PubChem	56032
ChemSpider	50586
UNII	7N8K34P2XH
KEGG	D07795
Hemijski podaci
Formula	C12H14N2
Mol. masa	186,253 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C12H14N2/c1-9-4-3-5-11(10(9)2)6-12-7-13-8-14-12/h3-5,7-8H,6H2,1-2H3,(H,13,14) ; Key: RHDJRPPFURBGLQ-UHFFFAOYSA-N
Farmakokinetički podaci
Poluvreme eliminacije	30 min
Farmakoinformacioni podaci
Trudnoća	?
Pravni status	Samo za veterinarsku upotrebu

Detomidin je imidazolni agonist α₂-adrenergičkog receptora koji se koristi kao sedativ za velike životinje, prvenstveno konje. On je obično dostupan u obliku soli detomidin hidrohlorida. Ovaj lek se izdanje na recepat. U prodaji je pod imenom Dormosedan.

Osobine

Detomidin je sedativ sa analgetičkim svojstvima.^[5] Agonisti α2-adrenergičkog receptora proizvode od doze zavisne sedativne i anagetičke efekte. Usled inhibicije simpatetičkog nervnog sistema, detomidin takođe utiče na srce, respiratorni sistem, a ima i antidiuretičko dejstvo.^[6]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ England GC, Clake KW. (1996). „α2 adrenoceptor in the horse: a review.”. Br Vet J. 152 (6): 641–657.
↑ Fornai F, Blandizzi C, del Tacca M. (1990). „Central alpha-2 adrenoceptors regulate central and peripheral functions”. Pharmacol Res. 22 (5): 541–54.

Vanjske veze

	Portal Medicina
	Portal Hemija

The Ontario Association of Equine Practitioners Arhivirano 2012-08-30 na Wayback Machine-u, Medication Protocols for Horses 2005
NOAH Compendium of Data Sheets for Animal Medicines 2005 Arhivirano 2012-08-06 na Wayback Machine-u

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] England GC, Clake KW. (1996). „α2 adrenoceptor in the horse: a review.”. Br Vet J. 152 (6): 641–657.

[6] Fornai F, Blandizzi C, del Tacca M. (1990). „Central alpha-2 adrenoceptors regulate central and peripheral functions”. Pharmacol Res. 22 (5): 541–54.

[1]

[2]

[3]

[4]

[5]

[6]