Beta timozin

alt text — NMR struktura β-timozina. Timozin α₁ ^[1] i β-timozini su intrinsično nestrukturirani proteini, i.e. njima nedostaje stabilno savijanje kad su slobodni u vodenom rastvoru. Ova struktura, koja je uglavnom alfa heliks, je veštački stabilizovana organskim rastvaračem.^[2]

Beta timozini su familija proteina koji imaju zajedničku sekvencu od oko 40 aminokiselina. Oni su slični peptidu timozin β₄. Beta timozini su prisutni u skoro isključivo u multićelijskim životinjama. Timozin β₄ je originalno izdvojen iz grudne žlezde zajedno sa nekoliko drugih peptida, i oni su dobili zajedničko ime timozini. Kasnije je utvrđeno da su ti proteini strukturno i genetički različiti i da su prisutni u mnogim životinjskim tkivima.

Reference

↑ Grottesi A, Sette M, Palamara T, Rotilio G, Garaci E, Paci M (1998). „The conformation of peptide thymosin alpha 1 in solution and in a membrane-like environment by circular dichroism and NMR spectroscopy. A possible model for its interaction with the lymphocyte membrane”. Peptides 19 (10): 1731–8. DOI:10.1016/S0196-9781(98)00132-6. PMID 9880079.
↑ PDB 1HJ0; Stoll R, Voelter W, Holak TA (May 1997). „Conformation of thymosin beta 9 in water/fluoroalcohol solution determined by NMR spectroscopy”. Biopolymers 41 (6): 623–34. DOI:10.1002/(SICI)1097-0282(199705)41:6<623::AID-BIP3>3.0.CO;2-S. PMID 9108730. »The thymosin is β9, bovine orthologue of human β10. Stabilised by organic solvent, the structure was determined by NMR. (Free β-thymosins lack a stable fold in solution)«

Povezano

[1] Grottesi A, Sette M, Palamara T, Rotilio G, Garaci E, Paci M (1998). „The conformation of peptide thymosin alpha 1 in solution and in a membrane-like environment by circular dichroism and NMR spectroscopy. A possible model for its interaction with the lymphocyte membrane”. Peptides 19 (10): 1731–8. DOI:10.1016/S0196-9781(98)00132-6. PMID 9880079.

[1HJ0.pdb-2] PDB 1HJ0; Stoll R, Voelter W, Holak TA (May 1997). „Conformation of thymosin beta 9 in water/fluoroalcohol solution determined by NMR spectroscopy”. Biopolymers 41 (6): 623–34. DOI:10.1002/(SICI)1097-0282(199705)41:6<623::AID-BIP3>3.0.CO;2-S. PMID 9108730. »The thymosin is β9, bovine orthologue of human β10. Stabilised by organic solvent, the structure was determined by NMR. (Free β-thymosins lack a stable fold in solution)«

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