bZIP domen

bZIP transkripcioni faktor
	CREB (gore) je transkripcioni faktor koji ima sposobnost vezivanja za DNK putem bZIP domena (dole) i regulisanja ekspresije gena.
Identifikatori
Simbol	bZIP_1
Pfam	PF00170
InterPro	IPR011616
PROSITE	PDOC00036
SCOP	1ysa
Superfamilija	1ysa
Dostupne PDB strukture:
Pfam	structures
PDB	RCSB PDB; PDBe
PDBsum	strukturni pregled

bZIP domen (engl. Basic Leucine Zipper Domain) je prisutan u mnogim eukariotskim proteinima koji vezuju DNK. Jedan deo domena sadrži region koji posreduje za sekvencu specifično DNK vezivanje i leucinski zatvarač koji je neophodan da bi se držala zajedno (dimerizovala) dva DNK vezujuća regiona. DNK vezujući region obuhvata više baznih aminokiselina kao što su arginin i lizin. Proteini koji sadrže ovaj domen su transkripcioni faktori.^[1]^[2]

bZIP transkripcioni faktori

bZIP transkripcioni faktori su prisutni u svim organizmima. Jedna nedavna evoluciona studija je pokazala da su 4 bZIP gena bila kodirana u genomu najskorijeg zajedničkog pretka svih biljki.^[3] Interakcije između bZIP transkripcionih faktora imaju važnu ulogu u razvoju kancera^[4] u epitelnim tkivima, sintezi steroidnih hormona u ćelijama endokrinih tkiva,^[5] faktora koji utiču na reproduktivne funkcije,^[6] i više drugih fenomena koji utiču na ljudsko zdravlje.

Proteini koji sadrže bZIP domen

AP-1 fos/jun heterodimer koji formira transkripcioni faktor
Jun-B transkripcioni faktor
CREB cAMP respons element transkripcioni faktor
OPAQUE2 (O2) transkripcioni faktor

Ljudski proteini koji sadrže ovaj domen

ATF1; ATF2; ATF4; ATF5; ATF6; ATF7; BACH1; BACH2; BATF; BATF2; CREB1; CREB3; CREB3L1; CREB3L2; CREB3L3; CREB3L4; CREB5; CREBL1; CREM; E4BP4; FOSL1; FOSL2; JUN; JUNB; JUND; MAFA; MAFB; NFE2; NFE2L2; NFE2L3; SNFT; CREM

Reference

↑ Ellenberger T (1994). „Getting a grip in DNA recognition: structures of the basic region leucine zipper, and the basic region helix-loop-helix DNA-binding domains.”. Curr. Opin. Struct. Biol. 4 (1): 12–21. DOI:10.1016/S0959-440X(94)90054-X.
↑ Hurst HC (1995). „Transcription factors 1: bZIP proteins”. Protein Profile 2 (2): 101–68. PMID 7780801.
↑ Corrêa LGG, Riaño-Pachón DM, Schrago CG, dos Santos RV, Mueller-Roeber B, Vincentz M. (2008). Shiu, Shin-Han. ur. „The Role of bZIP Transcription Factors in Green Plant Evolution: Adaptive Features Emerging from Four Founder Genes”. PLoS ONE 3 (8): e2944. DOI:10.1371/journal.pone.0002944. PMC 2492810. PMID 18698409.
↑ Vlahopoulos SA, Logotheti S, Mikas D, Giarika A, Gorgoulis V, Zoumpourlis V (April 2008). „The role of ATF-2 in oncogenesis”. BioEssays 30 (4): 314–27. DOI:10.1002/bies.20734. PMID 18348191.
↑ Manna PR, Dyson MT, Eubank DW, Clark BJ, Lalli E, Sassone-Corsi P, Zeleznik AJ, Stocco DM (January 2002). „Regulation of steroidogenesis and the steroidogenic acute regulatory protein by a member of the cAMP response-element binding protein family”. Mol. Endocrinol. 16 (1): 184–99. DOI:10.1210/me.16.1.184. PMID 11773448.
↑ Hoare S, Copland JA, Wood TG, Jeng YJ, Izban MG, Soloff MS (May 1999). „Identification of a GABP alpha/beta binding site involved in the induction of oxytocin receptor gene expression in human breast cells, potentiation by c-Fos/c-Jun”. Endocrinology 140 (5): 2268–79. DOI:10.1210/en.140.5.2268. PMID 10218980.

Spoljašnje veze

bZIP domain entry in the SMART database
Plant bZIP transcription factors Arhivirano 2012-03-20 na Wayback Machine-u

[Ellenberger_1994-1] Ellenberger T (1994). „Getting a grip in DNA recognition: structures of the basic region leucine zipper, and the basic region helix-loop-helix DNA-binding domains.”. Curr. Opin. Struct. Biol. 4 (1): 12–21. DOI:10.1016/S0959-440X(94)90054-X.

[pmid7780801-2] Hurst HC (1995). „Transcription factors 1: bZIP proteins”. Protein Profile 2 (2): 101–68. PMID 7780801.

[pmid18698409-3] Corrêa LGG, Riaño-Pachón DM, Schrago CG, dos Santos RV, Mueller-Roeber B, Vincentz M. (2008). Shiu, Shin-Han. ur. „The Role of bZIP Transcription Factors in Green Plant Evolution: Adaptive Features Emerging from Four Founder Genes”. PLoS ONE 3 (8): e2944. DOI:10.1371/journal.pone.0002944. PMC 2492810. PMID 18698409.

[pmid18348191-4] Vlahopoulos SA, Logotheti S, Mikas D, Giarika A, Gorgoulis V, Zoumpourlis V (April 2008). „The role of ATF-2 in oncogenesis”. BioEssays 30 (4): 314–27. DOI:10.1002/bies.20734. PMID 18348191.

[pmid11773448-5] Manna PR, Dyson MT, Eubank DW, Clark BJ, Lalli E, Sassone-Corsi P, Zeleznik AJ, Stocco DM (January 2002). „Regulation of steroidogenesis and the steroidogenic acute regulatory protein by a member of the cAMP response-element binding protein family”. Mol. Endocrinol. 16 (1): 184–99. DOI:10.1210/me.16.1.184. PMID 11773448.

[pmid10218980-6] Hoare S, Copland JA, Wood TG, Jeng YJ, Izban MG, Soloff MS (May 1999). „Identification of a GABP alpha/beta binding site involved in the induction of oxytocin receptor gene expression in human breast cells, potentiation by c-Fos/c-Jun”. Endocrinology 140 (5): 2268–79. DOI:10.1210/en.140.5.2268. PMID 10218980.

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