BD-1008

BD-1008
(IUPAC) ime
	2-(3,4-dichlorophenyl)-N-methyl-N-(2-pyrrolidin-1-ylethyl)ethanamine
Klinički podaci
Identifikatori
CAS broj	138356-08-8
ATC kod	nije dodeljen
PubChem	126388
Hemijski podaci
Formula	C15H22Cl2N2
Mol. masa	301.254 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C15H22Cl2N2/c1-18(10-11-19-7-2-3-8-19)9-6-13-4-5-14(16)15(17)12-13/h4-5,12H,2-3,6-11H2,1H3 ; Key: ASGIQUHBAVIOTI-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

BD-1008 je antagonist sigma receptora, koji blokira efekte kokaina u studijama na životinjama. On potencijalno može da bude koristan u razvoju antidota za lečenje kokainskog predoziranja.^[3]^[4]^[5]^[6]

Povezano

Sigma receptor

Literatura

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Monnet FP, de Costa BR, Bowen WD (September 1996). „Differentiation of sigma ligand-activated receptor subtypes that modulate NMDA-evoked [3H-noradrenaline release in rat hippocampal slices”]. British Journal of Pharmacology 119 (1): 65–72. PMC 1915737. PMID 8872358.
↑ Matsumoto RR, McCracken KA, Pouw B, Miller J, Bowen WD, Williams W, De Costa BR (January 2001). „N-alkyl substituted analogs of the sigma receptor ligand BD1008 and traditional sigma receptor ligands affect cocaine-induced convulsions and lethality in mice”. European Journal of Pharmacology 411 (3): 261–73. PMID 11164383.
↑ Matsumoto RR, McCracken KA, Friedman MJ, Pouw B, De Costa BR, Bowen WD (May 2001). „Conformationally restricted analogs of BD1008 and an antisense oligodeoxynucleotide targeting sigma1 receptors produce anti-cocaine effects in mice”. European Journal of Pharmacology 419 (2-3): 163–74. DOI:10.1016/S0014-2999(01)00968-2. PMID 11426838.
↑ Matsumoto RR, Gilmore DL, Pouw B, Bowen WD, Williams W, Kausar A, Coop A (May 2004). „Novel analogs of the sigma receptor ligand BD1008 attenuate cocaine-induced toxicity in mice”. European Journal of Pharmacology 492 (1): 21–6. DOI:10.1016/j.ejphar.2004.03.037. PMID 15145701.

Spoljašnje veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[pmid8872358-3] Monnet FP, de Costa BR, Bowen WD (September 1996). „Differentiation of sigma ligand-activated receptor subtypes that modulate NMDA-evoked [3H-noradrenaline release in rat hippocampal slices”]. British Journal of Pharmacology 119 (1): 65–72. PMC 1915737. PMID 8872358.

[pmid11164383-4] Matsumoto RR, McCracken KA, Pouw B, Miller J, Bowen WD, Williams W, De Costa BR (January 2001). „N-alkyl substituted analogs of the sigma receptor ligand BD1008 and traditional sigma receptor ligands affect cocaine-induced convulsions and lethality in mice”. European Journal of Pharmacology 411 (3): 261–73. PMID 11164383.

[pmid11426838-5] Matsumoto RR, McCracken KA, Friedman MJ, Pouw B, De Costa BR, Bowen WD (May 2001). „Conformationally restricted analogs of BD1008 and an antisense oligodeoxynucleotide targeting sigma1 receptors produce anti-cocaine effects in mice”. European Journal of Pharmacology 419 (2-3): 163–74. DOI:10.1016/S0014-2999(01)00968-2. PMID 11426838.

[pmid15145701-6] Matsumoto RR, Gilmore DL, Pouw B, Bowen WD, Williams W, Kausar A, Coop A (May 2004). „Novel analogs of the sigma receptor ligand BD1008 attenuate cocaine-induced toxicity in mice”. European Journal of Pharmacology 492 (1): 21–6. DOI:10.1016/j.ejphar.2004.03.037. PMID 15145701.

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