Alvamelin

Alvamelin
(IUPAC) ime
	3-(2-etiltetrazol-5-il)-1-metil-5,6-dihidro-2H-piridin
Klinički podaci
Identifikatori
CAS broj	120241-31-8
ATC kod	nije dodeljen
PubChem	178030
ChemSpider	154980
UNII	4XFD7B36M6
ChEMBL	CHEMBL131428
Hemijski podaci
Formula	C9H15N5
Mol. masa	193,25 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C9H15N5/c1-3-14-11-9(10-12-14)8-5-4-6-13(2)7-8/h5H,3-4,6-7H2,1-2H3 ; Key: RNMOMKCRCIRYCZ-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

Alvamelin (Lu 25-109) je agonist M₁ receptora i antagonist M₂/M₃ receptora.^[5] On je bio ispitivan za moguću primenu u lečenju Alchajmerove bolesti, ali je proizveo slabe rezultate u kliničkim ispitivanjima^[6] te je dalji razvoj prekinut.

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948863. edit
↑ Sánchez C, Arnt J, Didriksen M, Dragsted N, Moltzen Lenz S, Matz J (June 1998). „In vivo muscarinic cholinergic mediated effects of Lu 25-109, a M1 agonist and M2/M3 antagonist in vitro”. Psychopharmacology 137 (3): 233–40. DOI:10.1007/s002130050615. PMID 9683000. Arhivirano iz originala na datum 2000-10-02. Pristupljeno 2014-04-05.
↑ Sramek JJ, Forrest M, Mengel H, Jhee SS, Hourani J, Cutler NR (1998). „A bridging study of LU 25-109 in patients with probable Alzheimer's disease”. Life Sciences 62 (3): 195–202. DOI:10.1016/S0024-3205(97)01087-4. PMID 9488097.

Povezano

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948863. edit

[pmid9683000-5] Sánchez C, Arnt J, Didriksen M, Dragsted N, Moltzen Lenz S, Matz J (June 1998). „In vivo muscarinic cholinergic mediated effects of Lu 25-109, a M1 agonist and M2/M3 antagonist in vitro”. Psychopharmacology 137 (3): 233–40. DOI:10.1007/s002130050615. PMID 9683000. Arhivirano iz originala na datum 2000-10-02. Pristupljeno 2014-04-05.

[pmid9488097-6] Sramek JJ, Forrest M, Mengel H, Jhee SS, Hourani J, Cutler NR (1998). „A bridging study of LU 25-109 in patients with probable Alzheimer's disease”. Life Sciences 62 (3): 195–202. DOI:10.1016/S0024-3205(97)01087-4. PMID 9488097.

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