Mijanserin

Mijanserin
(IUPAC) ime
	(±)-2-metil-1,2,3,4,10,14b-heksahidrodibenzo[c,f]pirazino[1,2-a]azepin
Klinički podaci
AHFS/Drugs.com	Internacionalno ime leka
Identifikatori
CAS broj	24219-97-4
ATC kod	N06AX03
PubChem	4184
DrugBank	DB06148
ChemSpider	4040
UNII	250PJI13LM
KEGG	D08216
ChEBI	CHEBI:51137
ChEMBL	CHEMBL6437
Hemijski podaci
Formula	C18H20N2
Mol. masa	264,365
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C18H20N2/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19/h2-9,18H,10-13H2,1H3 ; Key: UEQUQVLFIPOEMF-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

Mijanserin (Bolvidon, Depnon, Norval, Tolvon) je psihoaktivni lek iz hemijske klase tetraciklični antidepresiv koji su klasifikovani kao noradrenergički i specifični serotonergički antidepresivi (NaSSA). Oni imaju antidepresivne, anksiolitske, hipnotičke, antiemetičke, oreksigenike, i antihistaminske efekte. Ranije je bio dostupan u mnoštvu zemalja. Na većini tržišta je zamenjen analozima i novijim lekom mirtazapinom (Remeronom).

Jedan interesantan nalaz je da nakon administracije, mijanserin povećava dužinu života nematoda Caenorhabditis elegans i do 30% u tečnom medijumi (sa lekom FUDR)^[6]. Ovaj efekat je verovatno uzrokovan modulacijom serotoninskog receptora.^[7]^[8] Kad se životinje drže u normalnom mediju za rast nematoda (NGM), mijanserin povećava akumulaciju masnoća i umanjuje dužinu života.^[9]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948863. edit
↑ Petrascheck M, Ye X, Buck LB (November 2007). „An antidepressant that extends lifespan in adult Caenorhabditis elegans”. Nature 450 (7169): 553–6. DOI:10.1038/nature05991. PMID 18033297.
↑ „Serotonin receptors antagonistically modulate Caenorhabditis elegans longevity”. Aging Cell 6 (4): 483–8. August 2007. DOI:10.1111/j.1474-9726.2007.00303.x. PMID 17559503.
↑ „Manipulation of serotonin signal suppresses early phase of behavioral aging in Caenorhabditis elegans”. Neurobiol. Aging 29 (7): 1093–100. July 2008. DOI:10.1016/j.neurobiolaging.2007.01.013. PMID 17336425.
↑ Zarse K, Ristow M (2008). Chapouthier, Georges. ur. „Antidepressants of the Serotonin-Antagonist Type Increase Body Fat and Decrease Lifespan of Adult Caenorhabditis elegans”. PLoS ONE 3 (12): e4062. DOI:10.1371/journal.pone.0004062. PMC 2605556. PMID 19112515.

Literatura

Peet, M; Behagel H (1978). „Mianserin: A decade of scientific development”. British Journal of Clinical Pharmacology (British Pharmacological Society) 5 (Suppl 1): 5S–9S. PMC 1429213. PMID 623702.

Spoljašnje veze

	Portal Medicina
	Portal Hemija

Treatments for Depression - Mianserin Arhivirano 2010-01-22 na Wayback Machine-u

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948863. edit

[pmid18033297-6] Petrascheck M, Ye X, Buck LB (November 2007). „An antidepressant that extends lifespan in adult Caenorhabditis elegans”. Nature 450 (7169): 553–6. DOI:10.1038/nature05991. PMID 18033297.

[7] „Serotonin receptors antagonistically modulate Caenorhabditis elegans longevity”. Aging Cell 6 (4): 483–8. August 2007. DOI:10.1111/j.1474-9726.2007.00303.x. PMID 17559503.

[8] „Manipulation of serotonin signal suppresses early phase of behavioral aging in Caenorhabditis elegans”. Neurobiol. Aging 29 (7): 1093–100. July 2008. DOI:10.1016/j.neurobiolaging.2007.01.013. PMID 17336425.

[9] Zarse K, Ristow M (2008). Chapouthier, Georges. ur. „Antidepressants of the Serotonin-Antagonist Type Increase Body Fat and Decrease Lifespan of Adult Caenorhabditis elegans”. PLoS ONE 3 (12): e4062. DOI:10.1371/journal.pone.0004062. PMC 2605556. PMID 19112515.

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