Dejodinaza
Dejodinaza (jodid peroksidaza, monodejodinaza) je peroksidazni enzim koji učestvuje u aktivaciji ili deaktivaciji tiroidnih hormona. Generalno, T4 (tiroksin) se konvertuje u T3 (trijodotironin) posredstvom enzima dejodinaze u ciljnim ćelijama.[1]
| Tiroksin 5'-dejodinaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.97.1.10 | ||||||||
| CAS broj | 70712-46-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| Ontologija gena | AmiGO / EGO | ||||||||
| |||||||||
Tipovi dejodinaza su:
| familija | prostetička grupa | geni |
|---|---|---|
| Jodotironin dejodinaza[2] | selenijum | DIO1, DIO2, DIO3 |
| Jodotirozin dejodinaza | flavin | IYD |
Pri gladovanju, dejodinaza je inhibirana i time se snižava nivo metabolizma. Međutim, u mozgu to noje slučaj.
Reference
uredi- ↑ Donald Voet, Judith G. Voet (2005). Biochemistry (3 izd.). Wiley. ISBN 978-0-471-19350-0.
- ↑ Dietrich Behne, Antonios Kyriakopoulos, Harald Meinhold, Josef Köhrle (1990-12-30). „Identification of type I iodothyronine 5′-deiodinase as a selenoenzyme”. Biochemical and Biophysical Research Communications 173 (3): 1143–1149.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.