Centre for Healthy Longevity

Exciting Research Update! Our latest systematic review explores the promising potential of #Urolithin A (UA), a gut metabolite derived from ellagic acid, in promoting #healthy #aging. Involving 250 healthy participants, the studies showed that UA supplementation (10–1000 mg/day for 28 days to 4 months) had several notable effects: - Dose-dependent anti-inflammatory effects - Upregulation of mitochondrial genes and markers of autophagy - Increased muscle strength and endurance While it didn't impact mitochondrial ATP production or gut microbiota, UA showed promising results without serious side effects. Congratulations to the team: Ajla Hodzic Kuerec MD, PhD, Xin Xuan Lin, Li Yang Anderson Khoo, Elena Sandalova, Lihuan Guan, FENG Lei, Andrea B. Maier NUS Yong Loo Lin School of Medicine Read the full paper here: https://lnkd.in/eYcMG-Ey #Longevity #HealthyAging #UrolithinA #ScientificResearch #Healthspan #AntiAging

We're excited to share our latest research: "Practical Guide for Choosing #Wearables in Community-Dwelling Adults" by our team led by Prof. Andrea B. Maier and Jessica Lu This guide offers a step-by-step approach for researchers, healthcare professionals, and device users, focusing on five core criteria: continuous monitoring, availability, accuracy, feasibility, and cost. By incorporating FDA, CTTI, and ePRO Consortium recommendations, the guide ensures a thorough and adaptable evaluation process that keeps up with rapid tech advancements. It aims to optimize device selection by balancing technical performance and user experience. Explore the full paper here: https://lnkd.in/eq9WwDR8 Weilan Wang Jorming G. NUS Yong Loo Lin School of Medicine NUS Academy for Healthy Longevity #WearableTech #HealthMonitoring #Research #HealthcareInnovation #ContinuousMonitoring #CommunityHealth

New Research Highlights Quality Concerns in Anti-Aging Supplements 🧬 A recent study by our research team led by Prof. Andrea B. Maier and Elena Sandalova analyzed 18 Nicotinamide Mononucleotide (NMN) and 5 Urolithin A (UA) supplements, which are widely marketed for their anti-aging benefits. We found significant discrepancies between the labeled and actual content of these supplements. Some products contained up to 28.6% more of the active ingredient than stated, while others had none at all. These findings underscore the need for improved quality control and stricter regulations in the supplement industry to ensure consumers receive reliable and accurate products. Link to full study: https://lnkd.in/eKgnxP4R NUS Yong Loo Lin School of Medicine (Elena Sandalova, Lihuan Guan, Brian Kennedy, Stephen Raj) and Temasek Polytechnic (Edmund Tian, @Huan L.) #HealthResearch #Supplements #AntiAging #QualityControl #ConsumerSafety #ScientificStudy

Prof. Andrea B. Maier will be speaking at #ARDD2024 from August 26-30 in Copenhagen! The meeting will feature a dynamic mix of academic institutions, clinicians, industry leaders, and pharmaceutical companies, fostering rich dialogues and unveiling new research in the field of aging. Prof. Andrea will be sharing her expertise on healthy longevity medicine, exploring both academic settings and clinical case discussions. You don’t want to miss her insights! Secure your spot now at agingpharma.org. Aging Research & Drug Discovery Meeting University of Copenhagen (Københavns Universitet) #HealthyAging #Longevity

A recent study done by Laure Verstraeten's team and Prof. Andrea B. Maier has shed light on the prevalence and co-occurrence of geriatric syndromes among elderly patients in #rehabilitation settings. Here are the key takeaways: 1. High Prevalence of Multiple Syndromes: 70% of patients presented with ≥5 geriatric syndromes at admission for both the RESORT and EMPOWER cohorts. These include medication overload (#polypharmacy), multiple #diseases (#multimorbidity), #physical limitations, and #frailty. 2. Co-occurrence of Syndromes: Nearly all patients had multiple co-occurring syndromes, underscoring the complexity of geriatric patient care in rehabilitation settings. Syndromes rarely occur in isolation. These findings highlight the necessity for comprehensive geriatric assessments (CGA) at admission to tailor rehabilitation plans effectively. For a deeper dive into the data and implications, refer to the full study here: https://lnkd.in/d_dbSu9v A special thanks to the research team for their contributions. Jos Kreeftmeijer, Janneke Van Wijngaarden, Carel Meskers Vrije Universiteit Amsterdam (VU Amsterdam), Cordaan, The Royal Melbourne Hospital, University of Melbourne, Danone Research & Innovation #HealthyAging #HealthyLongevity #GeriatricCare #Rehabilitation #HealthcareProfessionals #ClinicalResearch #Geriatrics #PatientCare #HealthOutcomes

Mr. Daniel Quek from ASEAN Alliance of Health Supplement Associations (AAHSA) shares compelling findings from the US Council for Responsible Nutrition study. Highlighting the economic impact of supplement interventions, the study reveals potential healthcare savings of billions through regimens like Omega-3 for CAD, Calcium and Vitamin D for fractures, and Vitamin B for cognitive decline. Preventative care is key to reducing costs and improving health spans. NUS Yong Loo Lin School of Medicine Andrea B. Maier #HealthSupplements #PreventativeCare #HealthcareSavings

Join the Forefront of Clinical Healthy Longevity Research at NUS! Are you passionate about making a lasting impact on human health and longevity? Do you thrive in a dynamic, collaborative environment where innovation and excellence are the driving forces? We are expanding our Clinical Trials Team at the NUS Yong Loo Lin School of Medicine to grow evidence-based precision healthy longevity medicine! We aim to optimize health and healthspan by targeting the aging processes of aging individuals with a focus on middle-aged populations. We are looking for: Research Associate – Job ID: 25097- https://lnkd.in/gaFhtc_d Research Fellow – Job ID: 25102- https://lnkd.in/gMs2giMN Research Assistant-Job ID: 24508-

Exciting new study alert! Professors Andrea B. Maier, @Carlos López-Otín, and Guido KROEMER, have published groundbreaking research in Nature Portfolio. They discovered that aging, like cancer, is driven by specific genes! In #cancer, mutations or overactive genes (#oncogenes) and failing tumor suppressor genes make cancer cells stronger and help them grow, dodging our body’s defenses. Similarly, #aging is influenced by genes that promote aging (#gerogenes) and the breakdown of protective genes. These genes impact overall health, leading to aging symptoms. By targeting these genes, precision medicine can be developed to slow aging and improve healthspan. This revolutionary approach offers hope for more personalized and effective treatments! Read more here: https://lnkd.in/eKN5eFz8 NUS Yong Loo Lin School of Medicine #CancerResearch #AgingScience #PrecisionMedicine #Genetics #HealthInnovation

Just 5 days to go until the Healthy Longevity Talent Incubator #HLTI2024, and J.J. (Hans) Meij and I can't wait to welcome this year's participants! We are thrilled to greet all 40 talented individuals coming from all corners of the globe. Each of them brings a unique background and a passion for healthy longevity, making this a truly special gathering.  I'll be diving into #longevity #medicine, discussing whether it's hype or hope, and covering #supplements and diagnostics for #biological aging. Hans has some fantastic #leadership workshops lined up to help them prepare for future careers. Get ready for an exciting 10-day journey filled with fun and knowledge. We can't wait to kick off the program with you all! NUS Academy for Healthy Longevity   Donate to support our program: https://lnkd.in/en_NsnGE  Part of the program is the Open Day presenting the results of the SG City Mission. Do you want to participate in this unique event? Registration: https://lnkd.in/eTkAwV_W #HLTI2024 #HealthyLongevity #Innovation #Research #Collaboration #Education