FLOT1

FLOT1
Identificadores
Nomes alternativos	FLOT1
IDs externos	OMIM: 606998 HomoloGene: 31337 GeneCards: FLOT1
Ontologia genética
Função molecular	• protease binding; • GO:0001948, GO:0016582 ligação a proteínas plasmáticas; • protein heterodimerization activity; • ionotropic glutamate receptor binding;
Componente celular	• integral component of membrane; • endossoma; • membrane; • cell-cell contact zone; • focal adhesion; • plasma membrane raft; • melanossomas; • membrana plasmática; • centriolar satellite; • centro organizador dos microtúbulos; • lysosomal membrane; • flotillin complex; • urópode; • basolateral plasma membrane; • early endosome; • apical plasma membrane; • cortical actin cytoskeleton; • caveola; • membrane raft; • COP9 signalosome; • sarcolema; • Exossoma; • GO:0016023 cytoplasmic vesicle; • lamellipodium; • cell-cell junction; • external side of plasma membrane; • sinapse; • presynaptic active zone; • dopaminergic synapse; • presynapse; • glutamatergic synapse; • GABA-ergic synapse;
Processo biológico	• positive regulation of cell-cell adhesion mediated by cadherin; • positive regulation of cell adhesion molecule production; • positive regulation of protein phosphorylation; • regulation of toll-like receptor 4 signaling pathway; • positive regulation of heterotypic cell-cell adhesion; • positive regulation of toll-like receptor 3 signaling pathway; • axonogenesis; • positive regulation of skeletal muscle tissue development; • GO:0032737 positive regulation of cytokine production; • extracellular matrix disassembly; • protein kinase C signaling; • response to endoplasmic reticulum stress; • positive regulation of myoblast fusion; • positive regulation of endocytosis; • positive regulation of cell junction assembly; • protein localization to membrane raft; • membrane raft assembly; • cellular response to exogenous dsRNA; • regulation of receptor internalization; • positive regulation of synaptic transmission, dopaminergic; • positive regulation of protein binding; • regulation of Rho protein signal transduction; • protein homooligomerization; • dsRNA transport; • plasma membrane raft assembly; • positive regulation of interferon-beta production; • protein stabilization; • protein localization to plasma membrane; • regulation of neurotransmitter uptake; • positive regulation of NF-kappaB transcription factor activity;
	Sources:Amigo / QuickGO
Padrão de expressão RNA
	; ; ; ;
	Mais dados de referência de expressão
Ortólogos
	10211
	n/a
ENSG00000137312; ENSG00000232280; ENSG00000224740; ENSG00000206480; ENSG00000206379;
	ENSG00000230143; ENSG00000236271; ENSG00000223654
	n/a
	O75955
	n/a
	NM_005803; NM_001318875
	n/a
	NP_001305804; NP_005794
	n/a
	Wikidata
Ver/Editar Humano

A flotilina-1 é uma proteína que em humanos é codificada pelo gene FLOT1.^[2]^[3]

Caveolae são pequenos domínios na membrana celular interna envolvidos no tráfego vesicular e na transdução de sinal. FLOT1 codifica uma proteína de membrana integral associada a caveolae.^[4] A função da flotilina 1 não foi determinada.^[3]

Interações

Foi demonstrado que FLOT1 interage com SORBS1.^[5]^[6]^[7]

Referências

↑ «Human PubMed Reference:»
↑ Hernandez-Hernandez, Victor; Jenkins, Dagan (15 de outubro de 2015). «Advances in the understanding of the BBSome complex structure and function». Research and Reports in Biology (em inglês). Consultado em 15 de junho de 2021
↑ ^a ^b «Entrez Gene: FLOT1 flotillin 1»
↑ Bickel, Perry E.; Scherer, Philipp E.; Schnitzer, Jan E.; Oh, Phil; Lisanti, Michael P.; Lodish, Harvey F. (23 de maio de 1997). «Flotillin and Epidermal Surface Antigen Define a New Family of Caveolae-associated Integral Membrane Proteins *». Journal of Biological Chemistry (em inglês) (21): 13793–13802. ISSN 0021-9258. PMID 9153235. doi:10.1074/jbc.272.21.13793. Consultado em 15 de junho de 2021
↑ Haglund K, Ivankovic-Dikic I, Shimokawa N, Kruh GD, Dikic I (maio 2004). «Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites». J. Cell Sci. 117 (Pt 12): 2557–68. PMID 15128873. doi:10.1242/jcs.01148
↑ Baumann CA, Ribon V, Kanzaki M, Thurmond DC, Mora S, Shigematsu S, Bickel PE, Pessin JE, Saltiel AR (setembro 2000). «CAP defines a second signalling pathway required for insulin-stimulated glucose transport» (PDF). Nature. 407 (6801): 202–7. Bibcode:2000Natur.407..202B. PMID 11001060. doi:10.1038/35025089. hdl:2027.42/62940
↑ Kimura A, Baumann CA, Chiang SH, Saltiel AR (julho 2001). «The sorbin homology domain: a motif for the targeting of proteins to lipid rafts». Proc. Natl. Acad. Sci. U.S.A. 98 (16): 9098–103. Bibcode:2001PNAS...98.9098K. PMC 55379. PMID 11481476. doi:10.1073/pnas.151252898

Leitura adicional

Maruyama K, Sugano S (1994). «Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.». Gene. 138 (1–2): 171–4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). «Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.». Gene. 200 (1–2): 149–56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3
Volonte D, Galbiati F, Li S, et al. (1999). «Flotillins/cavatellins are differentially expressed in cells and tissues and form a hetero-oligomeric complex with caveolins in vivo. Characterization and epitope-mapping of a novel flotillin-1 monoclonal antibody probe.». J. Biol. Chem. 274 (18): 12702–9. PMID 10212252. doi:10.1074/jbc.274.18.12702
Hazarika P, Dham N, Patel P, et al. (1999). «Flotillin 2 is distinct from epidermal surface antigen (ESA) and is associated with filopodia formation.». J. Cell. Biochem. 75 (1): 147–59. PMID 10462713. doi:10.1002/(SICI)1097-4644(19991001)75:1<147::AID-JCB15>3.0.CO;2-D
Hu RM, Han ZG, Song HD, et al. (2000). «Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.». Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. PMC 16901. PMID 10931946. doi:10.1073/pnas.160270997
Baumann CA, Ribon V, Kanzaki M, et al. (2000). «CAP defines a second signalling pathway required for insulin-stimulated glucose transport.» (PDF). Nature. 407 (6801): 202–7. Bibcode:2000Natur.407..202B. PMID 11001060. doi:10.1038/35025089. hdl:2027.42/62940
Zhang QH, Ye M, Wu XY, et al. (2001). «Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34 hematopoietic stem/progenitor cells.». Genome Res. 10 (10): 1546–60. PMC 310934. PMID 11042152. doi:10.1101/gr.140200
Salzer U, Prohaska R (2001). «Stomatin, flotillin-1, and flotillin-2 are major integral proteins of erythrocyte lipid rafts.». Blood. 97 (4): 1141–3. PMID 11159550. doi:10.1182/blood.V97.4.1141
Edgar AJ, Polak JM (2001). «Flotillin-1: gene structure: cDNA cloning from human lung and the identification of alternative polyadenylation signals.». Int. J. Biochem. Cell Biol. 33 (1): 53–64. PMID 11167132. doi:10.1016/S1357-2725(00)00069-8
Kimura A, Baumann CA, Chiang SH, Saltiel AR (2001). «The sorbin homology domain: a motif for the targeting of proteins to lipid rafts.». Proc. Natl. Acad. Sci. U.S.A. 98 (16): 9098–103. Bibcode:2001PNAS...98.9098K. PMC 55379. PMID 11481476. doi:10.1073/pnas.151252898
Stuermer CA, Lang DM, Kirsch F, et al. (2002). «Glycosylphosphatidyl inositol-anchored proteins and fyn kinase assemble in noncaveolar plasma membrane microdomains defined by reggie-1 and -2.». Mol. Biol. Cell. 12 (10): 3031–45. PMC 60153. PMID 11598189. doi:10.1091/mbc.12.10.3031
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). «Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.». Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899
Girardot N, Allinquant B, Duyckaerts C (2004). «[Lipid rafts, flotillin-1 and Alzheimer disease]». J. Soc. Biol. 197 (3): 223–9. PMID 14708344. doi:10.1051/jbio/2003197030223
Wakasugi K, Nakano T, Kitatsuji C, Morishima I (2004). «Human neuroglobin interacts with flotillin-1, a lipid raft microdomain-associated protein.». Biochem. Biophys. Res. Commun. 318 (2): 453–60. PMID 15120622. doi:10.1016/j.bbrc.2004.04.045
Haglund K, Ivankovic-Dikic I, Shimokawa N, et al. (2004). «Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites.». J. Cell Sci. 117 (Pt 12): 2557–68. PMID 15128873. doi:10.1242/jcs.01148
Bared SM, Buechler C, Boettcher A, et al. (2005). «Association of ABCA1 with syntaxin 13 and flotillin-1 and enhanced phagocytosis in tangier cells.». Mol. Biol. Cell. 15 (12): 5399–407. PMC 532019. PMID 15469992. doi:10.1091/mbc.E04-03-0182
Gerhard DS, Wagner L, Feingold EA, et al. (2004). «The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).». Genome Res. 14 (10B): 2121–7. PMC 528928. PMID 15489334. doi:10.1101/gr.2596504
Jacobowitz DM, Kallarakal AT (2005). «Flotillin-1 in the substantia nigra of the Parkinson brain and a predominant localization in catecholaminergic nerves in the rat brain.». Neurotoxicity Research. 6 (4): 245–57. PMID 15545008. doi:10.1007/BF03033435
Pope SN, Lee IR (2005). «Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin.». J. Steroid Biochem. Mol. Biol. 94 (1–3): 203–8. PMID 15862967. doi:10.1016/j.jsbmb.2005.01.007
Glebov OO, Bright NA, Nichols BJ (2006). «Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cells.». Nat. Cell Biol. 8 (1): 46–54. PMID 16341206. doi:10.1038/ncb1342

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Ligações externas

[1] «Human PubMed Reference:»

[2] Hernandez-Hernandez, Victor; Jenkins, Dagan (15 de outubro de 2015). «Advances in the understanding of the BBSome complex structure and function». Research and Reports in Biology (em inglês). Consultado em 15 de junho de 2021

[entrez-3] «Entrez Gene: FLOT1 flotillin 1»

[4] Bickel, Perry E.; Scherer, Philipp E.; Schnitzer, Jan E.; Oh, Phil; Lisanti, Michael P.; Lodish, Harvey F. (23 de maio de 1997). «Flotillin and Epidermal Surface Antigen Define a New Family of Caveolae-associated Integral Membrane Proteins *». Journal of Biological Chemistry (em inglês) (21): 13793–13802. ISSN 0021-9258. PMID 9153235. doi:10.1074/jbc.272.21.13793. Consultado em 15 de junho de 2021

[pmid15128873-5] Haglund K, Ivankovic-Dikic I, Shimokawa N, Kruh GD, Dikic I (maio 2004). «Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites». J. Cell Sci. 117 (Pt 12): 2557–68. PMID 15128873. doi:10.1242/jcs.01148

[pmid11001060-6] Baumann CA, Ribon V, Kanzaki M, Thurmond DC, Mora S, Shigematsu S, Bickel PE, Pessin JE, Saltiel AR (setembro 2000). «CAP defines a second signalling pathway required for insulin-stimulated glucose transport» (PDF). Nature. 407 (6801): 202–7. Bibcode:2000Natur.407..202B. PMID 11001060. doi:10.1038/35025089. hdl:2027.42/62940

[pmid11481476-7] Kimura A, Baumann CA, Chiang SH, Saltiel AR (julho 2001). «The sorbin homology domain: a motif for the targeting of proteins to lipid rafts». Proc. Natl. Acad. Sci. U.S.A. 98 (16): 9098–103. Bibcode:2001PNAS...98.9098K. PMC 55379. PMID 11481476. doi:10.1073/pnas.151252898

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