AGPAT1

AGPAT1
Identificadores
Nomes alternativos	AGPAT1
IDs externos	OMIM: 603099 HomoloGene: 55973 GeneCards: AGPAT1
Ontologia genética
Função molecular	• transferase activity; • acyltransferase activity; • 1-acylglycerol-3-phosphate O-acyltransferase activity; • GO:0001948, GO:0016582 ligação a proteínas plasmáticas;
Componente celular	• integral component of membrane; • endoplasmic reticulum membrane; • membrane; • retículo endoplasmático;
Processo biológico	• phosphatidic acid biosynthetic process; • CDP-diacylglycerol biosynthetic process; • positive regulation of cytokine-mediated signaling pathway; • GO:0032737 positive regulation of cytokine production; • metabolismo dos lipídios; • phospholipid biosynthetic process; • phospholipid metabolic process; • metabolismo; • positive regulation of cellular metabolic process;
	Sources:Amigo / QuickGO
Padrão de expressão RNA
	; ;
	Mais dados de referência de expressão
Ortólogos
	10554
	n/a
ENSG00000236873; ENSG00000235758; ENSG00000228892; ENSG00000204310; ENSG00000226467;
	ENSG00000227642; ENSG00000206324
	n/a
	Q99943
	n/a
	NM_006411; NM_032741; NM_001371437; NM_001371438; NM_001371439
	n/a
	NP_006402; NP_116130; NP_001358366; NP_001358367; NP_001358368
	n/a
	Wikidata
Ver/Editar Humano

Alfa 1-acil-sn-glicerol-3-fosfato aciltransferase é uma enzima que em humanos é codificada pelo gene AGPAT1. Este gene codifica uma enzima que converte o ácido lisofosfatídico (LPA) em ácido fosfatídico (PA). LPA e PA são dois fosfolipídios envolvidos na transdução de sinal e na biossíntese de lipídios nas células.

Referências

↑ «Human PubMed Reference:»

Leitura adicional

Leung DW (2001). «The structure and functions of human lysophosphatidic acid acyltransferases.». Front. Biosci. 6 (1): D944–53. PMID 11487472. doi:10.2741/Leung
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). «A "double adaptor" method for improved shotgun library construction.». Anal. Biochem. 236 (1): 107–13. PMID 8619474. doi:10.1006/abio.1996.0138
Yu W, Andersson B, Worley KC, et al. (1997). «Large-scale concatenation cDNA sequencing.». Genome Res. 7 (4): 353–8. PMC 139146. PMID 9110174. doi:10.1101/gr.7.4.353
West J, Tompkins CK, Balantac N, et al. (1997). «Cloning and expression of two human lysophosphatidic acid acyltransferase cDNAs that enhance cytokine-induced signaling responses in cells.». DNA Cell Biol. 16 (6): 691–701. PMID 9212163. doi:10.1089/dna.1997.16.691
Aguado B, Campbell RD (1998). «Human lysophosphatidic acid acyltransferase is encoded by a gene located in the major histocompatibility complex.». Biochem. Soc. Trans. 25 (4): S597. PMID 9450025
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). «Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.». Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899
Mungall AJ, Palmer SA, Sims SK, et al. (2003). «The DNA sequence and analysis of human chromosome 6.». Nature. 425 (6960): 805–11. PMID 14574404. doi:10.1038/nature02055
Xie T, Rowen L, Aguado B, et al. (2004). «Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.». Genome Res. 13 (12): 2621–36. PMC 403804. PMID 14656967. doi:10.1101/gr.1736803
Ota T, Suzuki Y, Nishikawa T, et al. (2004). «Complete sequencing and characterization of 21,243 full-length human cDNAs.». Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285
Gerhard DS, Wagner L, Feingold EA, et al. (2004). «The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).». Genome Res. 14 (10B): 2121–7. PMC 528928. PMID 15489334. doi:10.1101/gr.2596504
Servillo L, Balestrieri C, Giovane A, et al. (2006). «Lysophospholipid transacetylase in the regulation of PAF levels in human monocytes and macrophages.». FASEB J. 20 (7): 1015–7. PMID 16571775. doi:10.1096/fj.05-5059fje
Lloyd EE, Gaubatz JW, Burns AR, Pownall HJ (2007). «Sustained elevations in NEFA induce cyclooxygenase-2 activity and potentiate THP-1 macrophage foam cell formation.». Atherosclerosis. 192 (1): 49–55. PMID 16870193. doi:10.1016/j.atherosclerosis.2006.06.014

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[1] «Human PubMed Reference:»

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