Artigos de Edgar
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Job Opportunity Project Manager - Lisbon, Paris, Heidelberg
Job Opportunity Project Manager - Lisbon, Paris, Heidelberg
De Edgar Gomes
Atividades
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📅No dia 25 de julho, o Município de Cantanhede prestou homenagem a dois prestigiados membros da Comunidade do Biocant Park, Carlos Faro e Euclides…
📅No dia 25 de julho, o Município de Cantanhede prestou homenagem a dois prestigiados membros da Comunidade do Biocant Park, Carlos Faro e Euclides…
Edgar Gomes gostou
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Exciting News: Welcoming Dr. Philippos Mourikis to INEM - Institut Necker Enfants Malades! We are excited to share that Philippos Mourikis, CNRS…
Exciting News: Welcoming Dr. Philippos Mourikis to INEM - Institut Necker Enfants Malades! We are excited to share that Philippos Mourikis, CNRS…
Edgar Gomes gostou
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I am deeply honored to be elected as an EMBO Member. My heartfelt thanks to all current and former lab members, collaborators, mentors, colleagues…
I am deeply honored to be elected as an EMBO Member. My heartfelt thanks to all current and former lab members, collaborators, mentors, colleagues…
Edgar Gomes gostou
Experiência
Publicações
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Moving and positioning the nucleus in skeletal muscle - one step at a time.
Nucleus
Nuclear movement and positioning within cells has become an area of great interest in the past few years due to the identification of different molecular mechanisms and functions in distinct organisms and contexts. One extreme example occurs during skeletal muscle development and regeneration. Skeletal muscles are composed of individual multinucleated myofibers with nuclei positioned at their periphery. Myofibers are formed by fusion of mononucleated myoblasts and during their development…
Nuclear movement and positioning within cells has become an area of great interest in the past few years due to the identification of different molecular mechanisms and functions in distinct organisms and contexts. One extreme example occurs during skeletal muscle development and regeneration. Skeletal muscles are composed of individual multinucleated myofibers with nuclei positioned at their periphery. Myofibers are formed by fusion of mononucleated myoblasts and during their development, successive nuclear movements and positioning events have been described. The position of the nuclei in myofibers is important for muscle function. Interestingly, during muscle regeneration and in some muscular diseases, nuclei are positioned in the center of the myofiber. In this review, we discuss the multiple mechanisms of nuclear positioning that occur during myofiber formation and regeneration. We also discuss the role of nuclear positioning for skeletal muscle function.
Outros autoresVer publicação -
N-WASP is required for Amphiphysin-2/BIN1-dependent nuclear positioning and triad organization in skeletal muscle and is involved in the pathophysiology of centronuclear myopathy
EMBO Mol Med
EMBO Mol Med. 2014 Sep 28;6(11):1455-75.
N-WASP is required for Amphiphysin-2/BIN1-dependent nuclear positioning and triad organization in skeletal muscle and is involved in the pathophysiology of centronuclear myopathy.
Falcone S1, Roman W2, Hnia K3, Gache V4, Didier N2, Lainé J5, Auradé F2, Marty I6, Nishino I7, Charlet-Berguerand N3, Romero NB8, Marazzi G2, Sassoon D2, Laporte J3, Gomes ER9.
Author information
Abstract
Mutations in amphiphysin-2/BIN1, dynamin 2, and…EMBO Mol Med. 2014 Sep 28;6(11):1455-75.
N-WASP is required for Amphiphysin-2/BIN1-dependent nuclear positioning and triad organization in skeletal muscle and is involved in the pathophysiology of centronuclear myopathy.
Falcone S1, Roman W2, Hnia K3, Gache V4, Didier N2, Lainé J5, Auradé F2, Marty I6, Nishino I7, Charlet-Berguerand N3, Romero NB8, Marazzi G2, Sassoon D2, Laporte J3, Gomes ER9.
Author information
Abstract
Mutations in amphiphysin-2/BIN1, dynamin 2, and myotubularin are associated with centronuclear myopathy (CNM), a muscle disorder characterized by myofibers with atypical central nuclear positioning and abnormal triads. Mis-splicing of amphiphysin-2/BIN1 is also associated with myotonic dystrophy that shares histopathological hallmarks with CNM. How amphiphysin-2 orchestrates nuclear positioning and triad organization and how CNM-associated mutations lead to muscle dysfunction remains elusive. We find that N-WASP interacts with amphiphysin-2 in myofibers and that this interaction and N-WASP distribution are disrupted by amphiphysin-2 CNM mutations. We establish that N-WASP functions downstream of amphiphysin-2 to drive peripheral nuclear positioning and triad organization during myofiber formation. Peripheral nuclear positioning requires microtubule/Map7/Kif5b-dependent distribution of nuclei along the myofiber and is driven by actin and nesprins. In adult myofibers, N-WASP and amphiphysin-2 are only involved in the maintenance of triad organization but not in the maintenance of peripheral nuclear positioning. Importantly, we confirmed that N-WASP distribution is disrupted in CNM and myotonic dystrophy patients. Our results support a role for N-WASP in amphiphysin-2-dependent nuclear positioning and triad organization and in CNM and myotonic dystrophy pathophysiology.Outros autoresVer publicação -
Nuclear movement during myotube formation is microtubule and dynein dependent and is regulated by Cdc42, Par6 and Par3
EMBO Report
Cells actively position their nucleus within the cytoplasm. One striking example is observed during skeletal myogenesis. Differentiated myoblasts fuse to form a multinucleated myotube with nuclei positioned in the centre of the syncytium by an unknown mechanism. Here, we describe that the nucleus of a myoblast moves rapidly after fusion towards the central myotube nuclei. This movement is driven by microtubules and dynein/dynactin complex, and requires Cdc42, Par6 and Par3. We found that Par6β…
Cells actively position their nucleus within the cytoplasm. One striking example is observed during skeletal myogenesis. Differentiated myoblasts fuse to form a multinucleated myotube with nuclei positioned in the centre of the syncytium by an unknown mechanism. Here, we describe that the nucleus of a myoblast moves rapidly after fusion towards the central myotube nuclei. This movement is driven by microtubules and dynein/dynactin complex, and requires Cdc42, Par6 and Par3. We found that Par6β and dynactin accumulate at the nuclear envelope of differentiated myoblasts and myotubes, and this accumulation is dependent on Par6 and Par3 proteins but not on microtubules. These results suggest a mechanism where nuclear movement after fusion is driven by microtubules that emanate from one nucleus that are pulled by dynein/dynactin complex anchored to the nuclear envelope of another nucleus.
Outros autoresVer publicação -
Identification and characterization of a non-satellite cell muscle resident progenitor during postnatal development
Nature Cell Biology
Satellite cells are resident myogenic progenitors in postnatal skeletal muscle involved in muscle postnatal growth and adult regenerative capacity. Here, we identify and describe a population of muscle-resident stem cells, which are located in the interstitium, that express the cell stress mediator PW1 but do not express other markers of muscle stem cells such as Pax7. PW1( )/Pax7(-) interstitial cells (PICs) are myogenic in vitro and efficiently contribute to skeletal muscle regeneration in…
Satellite cells are resident myogenic progenitors in postnatal skeletal muscle involved in muscle postnatal growth and adult regenerative capacity. Here, we identify and describe a population of muscle-resident stem cells, which are located in the interstitium, that express the cell stress mediator PW1 but do not express other markers of muscle stem cells such as Pax7. PW1( )/Pax7(-) interstitial cells (PICs) are myogenic in vitro and efficiently contribute to skeletal muscle regeneration in vivo as well as generating satellite cells and PICs. Whereas Pax7 mutant satellite cells show robust myogenic potential, Pax7 mutant PICs are unable to participate in myogenesis and accumulate during postnatal growth. Furthermore, we found that PICs are not derived from a satellite cell lineage. Taken together, our findings uncover a new and anatomically identifiable population of muscle progenitors and define a key role for Pax7 in a non-satellite cell population during postnatal muscle growth.
Outros autores -
Identification and characterization of a non-satellite cell muscle resident progenitor during postnatal development
Nature Cell Biology
Satellite cells are resident myogenic progenitors in postnatal skeletal muscle involved in muscle postnatal growth and adult regenerative capacity. Here, we identify and describe a population of muscle-resident stem cells, which are located in the interstitium, that express the cell stress mediator PW1 but do not express other markers of muscle stem cells such as Pax7. PW1( )/Pax7(-) interstitial cells (PICs) are myogenic in vitro and efficiently contribute to skeletal muscle regeneration in…
Satellite cells are resident myogenic progenitors in postnatal skeletal muscle involved in muscle postnatal growth and adult regenerative capacity. Here, we identify and describe a population of muscle-resident stem cells, which are located in the interstitium, that express the cell stress mediator PW1 but do not express other markers of muscle stem cells such as Pax7. PW1( )/Pax7(-) interstitial cells (PICs) are myogenic in vitro and efficiently contribute to skeletal muscle regeneration in vivo as well as generating satellite cells and PICs. Whereas Pax7 mutant satellite cells show robust myogenic potential, Pax7 mutant PICs are unable to participate in myogenesis and accumulate during postnatal growth. Furthermore, we found that PICs are not derived from a satellite cell lineage. Taken together, our findings uncover a new and anatomically identifiable population of muscle progenitors and define a key role for Pax7 in a non-satellite cell population during postnatal muscle growth.
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Patentes
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English
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Portuguese
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French
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Organizações
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american society for cell biology
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- o momento
Mais atividade de Edgar
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Thank you to all my colleagues at CRM - Centre de Recherche en Myologie, INSERM, Inserm | Cellule Europe and international partners for their efforts…
Thank you to all my colleagues at CRM - Centre de Recherche en Myologie, INSERM, Inserm | Cellule Europe and international partners for their efforts…
Edgar Gomes gostou
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I was asked to write a commentary for Nature Structural and Molecular Biology as part of a celebration of their 30 years. I wrote about the value of…
I was asked to write a commentary for Nature Structural and Molecular Biology as part of a celebration of their 30 years. I wrote about the value of…
Edgar Gomes gostou
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Thrilled to have participated in the #mdcAlumni day 2024! It was a fantastic opportunity to reconnect with colleagues and forge a new network! The…
Thrilled to have participated in the #mdcAlumni day 2024! It was a fantastic opportunity to reconnect with colleagues and forge a new network! The…
Edgar Gomes gostou
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I am thrilled to announce that last week I completed my PhD! I want to express my gratitude to my supervisors, Sérgio de Almeida and Edgar Gomes…
I am thrilled to announce that last week I completed my PhD! I want to express my gratitude to my supervisors, Sérgio de Almeida and Edgar Gomes…
Edgar Gomes gostou
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Sei que não é televisão nem eu sou jovem, mas deixo-vos um carismático comentário à investigação multidisciplinar e à política de ciência nacional…
Sei que não é televisão nem eu sou jovem, mas deixo-vos um carismático comentário à investigação multidisciplinar e à política de ciência nacional…
Edgar Gomes gostou
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Just to call your attention that the Gabinete de Apoio à Investigação Científica, Tecnológica e Inovação (GAPIC) is looking for a Project Manager…
Just to call your attention that the Gabinete de Apoio à Investigação Científica, Tecnológica e Inovação (GAPIC) is looking for a Project Manager…
Compartilhado por Edgar Gomes
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I am glad to announce that I was selected for The Global Youth Leaders Program (GYL) on the track of Inclusion and Equal Opportunities. This…
I am glad to announce that I was selected for The Global Youth Leaders Program (GYL) on the track of Inclusion and Equal Opportunities. This…
Edgar Gomes gostou
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We are currently looking for 2 post-docs to join our group to work on mechanisms involving the formation and maintenance of skeletal muscle, with…
We are currently looking for 2 post-docs to join our group to work on mechanisms involving the formation and maintenance of skeletal muscle, with…
Compartilhado por Edgar Gomes
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PhD fellowship! If you want to learn about timelapse and superresolution microscopy, and you want to understand how cell structure is related with…
PhD fellowship! If you want to learn about timelapse and superresolution microscopy, and you want to understand how cell structure is related with…
Compartilhado por Edgar Gomes
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É com o maior orgulho que anunciamos a condecoração do Professor Fausto Pinto pelo Presidente da República, o Professor Marcelo Rebelo de Sousa, com…
É com o maior orgulho que anunciamos a condecoração do Professor Fausto Pinto pelo Presidente da República, o Professor Marcelo Rebelo de Sousa, com…
Edgar Gomes gostou
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"Everyone thinks of changing humanity, and no one thinks of changing himself". LEO TOLSTOY, 1900
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