Supergirl O Brother, Where Art Thou? (Season 4, Episode 15)
TV-PG
TV Episode | 42 min | Action, Adventure, Drama

Primary photo for O Brother, Where Art Thou?

Supergirl

O Brother, Where Art Thou? (Season 4, Episode 15)

TV-PG

TV Episode | 42 min | Action, Adventure, Drama

Secretly furloughed from prison due to failing health, Lex Luthor visits his sister Lena to seek her help finding a cure. Savvy as ever, Lena is suspicious of Lex's motives, but when she's faced with a life and death situation, she must ...See moreSecretly furloughed from prison due to failing health, Lex Luthor visits his sister Lena to seek her help finding a cure. Savvy as ever, Lena is suspicious of Lex's motives, but when she's faced with a life and death situation, she must decide how she truly feels about her brother. Meanwhile, Supergirl and J'onn face off against Manchester Black. James' sister Kelly comes to town. Written by Derek Simon & Nicki Holcomb See less

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Cast	Add Cast
19 cast members

Name	Known for
Melissa Benoist Kara Danvers / Supergirl Kara Danvers / Supergirl See fewer	Supergirl (2015)
Mehcad Brooks James Olsen James Olsen See fewer	Desperate Housewives (2004)
Chyler Leigh Alex Danvers Alex Danvers See fewer	Not Another Teen Movie (2001)
Katie McGrath Lena Luthor Lena Luthor See fewer	Jurassic World (2015)
Jesse Rath Querl Dox / Brainiac-5 Querl Dox / Brainiac-5 See fewer	Supergirl (2015)
Sam Witwer Ben Lockwood (credit only) Ben Lockwood (credit only) See fewer	The Mist (2007)
Nicole Maines Nia Nal Nia Nal See fewer	Yellowjackets (2021)
April Parker Jones Colonel Lauren Haley (credit only) Colonel Lauren Haley (credit only) See fewer	Spider-Man 3 (2007)
David Harewood J'onn J'onzz / Martian Manhunter J'onn J'onzz / Martian Manhunter See fewer	Blood Diamond (2006)
Jon Cryer Lex Luthor Lex Luthor See fewer	Two and a Half Men (2003)
David Ajala Manchester Black Manchester Black See fewer	Jupiter Ascending (2015)
Robert Baker Otis Graves Otis Graves See fewer	Indiana Jones and the Kingdom of the Crystal Skull (2008)
Azie Tesfai Kelly Olsen Kelly Olsen See fewer	Jane the Virgin (2014)
Andrea Brooks Eve Teschmacher Eve Teschmacher See fewer	When Calls the Heart (2014)
William MacDonald Dr. Kaplan Dr. Kaplan See fewer	Riverdale (2017)
Byron Brisco Guard #2 Guard #2 See fewer	I, Robot (2004)
Christina Lewall Trauma Doctor Trauma Doctor See fewer	Torn: Dark Bullets (2020)
Lincoln McGowan Guard Guard See fewer	Timeless (2016)
Amos Stern Guard #3 Guard #3 See fewer	Smallville (2001)