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The word locus (plural loci) is Latin for "place".
In biology, a locus describes the position of a gene on a chromosome. A locus can be occupied by any of the alleles of the gene. Diploid or polyploid cells are either homozygote (have the same allele at a locus) or heterozygote (have different alleles at a locus).
In mathematics, a locus is the set of points satisfying a particular condition. It is mostly used when the set of points forms a curve of some sort.