Sukru Genco

❓ 𝙃𝙖𝙫𝙚 𝙮𝙤𝙪 𝙚𝙫𝙚𝙧 𝙬𝙤𝙣𝙙𝙚𝙧𝙚𝙙 𝙬𝙝𝙞𝙘𝙝 𝙝𝙚𝙖𝙧𝙩 𝙛𝙖𝙞𝙡𝙪𝙧𝙚 𝙥𝙖𝙩𝙞𝙚𝙣𝙩𝙨 𝙗𝙚𝙣𝙚𝙛𝙞𝙩 𝙛𝙧𝙤𝙢 𝙣𝙤𝙣-𝙞𝙣𝙫𝙖𝙨𝙞𝙫𝙚 𝙩𝙚𝙡𝙚𝙢𝙚𝙙𝙞𝙘𝙞𝙣𝙚? Pleased to announce the publication of our scoping review in #NHJ, where we evaluate and synthesize evidence on the effectiveness of telemedicine across heart failure subpopulations. Our review reveals:   💡 𝗜𝗻𝗰𝗼𝗻𝗰𝗹𝘂𝘀𝗶𝘃𝗲 𝗘𝘃𝗶𝗱𝗲𝗻𝗰𝗲: Study findings varied, with no definitive evidence on which patients benefit most from telemedicine due to inconsistent subgroup definitions and small sample sizes; 👫 𝗡𝗲𝗲𝗱 𝗳𝗼𝗿 𝗦𝘂𝗯𝗴𝗿𝗼𝘂𝗽 𝗔𝗻𝗮𝗹𝘆𝘀𝗲𝘀: Future research should focus on (multivariable) subgroup analyses to identify who benefits from telemedicine and when in the course of HF; 📝 𝗟𝗶𝗺𝗶𝘁𝗮𝘁𝗶𝗼𝗻𝘀 𝗼𝗳 𝘁𝗿𝗮𝗱𝗶𝘁𝗶𝗼𝗻𝗮𝗹 𝗥𝗖𝗧𝘀: Current RCTs have not provided clear guidance for clinicians; 📊 𝗔𝗹𝘁𝗲𝗿𝗻𝗮𝘁𝗶𝘃𝗲 𝗔𝗽𝗽𝗿𝗼𝗮𝗰𝗵𝗲𝘀: Replication studies and observational studies using electronic health records linked with telemedicine device data may offer more tailored insights. I would like to thank all co-authors Kim Luijken, Jaap Trappenburg PhD, Tiny Jaarsma, and Folkert Asselbergs for their valuable contribution. Read the full article here: https://lnkd.in/eKHRVFzp #HeartFailure #Telemedicine #eHealth #PersonalisedMedicine #LearningHealthcareSystem #RELEASE-HF UMC Utrecht Circulatory Health UMC Utrecht

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Hope vs. Hype III: Rescue/on-demand therapies are preferable to device-assisted therapies in Parkinson disease The Parkinson Study Group (PSG) gathered North American experts in Parkinson disease during the 9th Annual Symposium, Shaping the Management of Parkinson Disease: Debating Current Controversies. Debaters were tasked with agree or disagree positions to a particular prompt. This is the third in the series of “Hype versus Hope” debates involving current trends and advances in Parkinson disease. With the prompt of “Rescue/On-demand therapies are preferable to device-assisted therapies in Parkinson disease,” Dr. Stuart Isaacson, MD was tasked with the “agree” stance and Dr. Joohi Jimenez-Shahed, MD was tasked with the “disagree” stance. The following point-of-view article is an adaptation of this debate. IAPRD Secretariat Read the full article: https://lnkd.in/gC_am-SV

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What is the current status on AF ablation in patients with congenital heart disease? Read our Top Story in Heart Rhythm Journal. Together with Can Zhang.

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💥 Very proud to announce that our paper ‘Relative wash-in rate in dynamic contrast-enhanced magnetic resonance imaging as a new prognostic biomarker for event-free survival in 82 patients with osteosarcoma: a multicenter study’ has just been published in Cancers 💥 ✔ In a previous multicenter study at the Leiden University Medical Center (LUMC – Leiden – The Netherlands) and at the Ghent University Hospital (UZG – Ghent – Belgium), we determined that on dynamic contrast-enhanced MRI (DCE-MRI), a relative wash-in rate (rWIR) cut-off of 2.3 predicted histological response to neoadjuvant chemotherapy in osteosarcoma patients (https://lnkd.in/eNyBr-82). ✔ The current study explores the potential of rWIR as a prognostic biomarker for event-free survival (EFS) in 82 osteosarcoma patients. Patients with rWIR < 2.3 were considered to have a poor radiological response, while those with rWIR ≥ 2.3 had a good response. Poor radiological response was associated with shorter EFS, even when adjusted for traditional prognostic factors. The 2- and 5-year EFS rates for patients with rWIR ≥ 2.3 were 85% and 75%, compared to 55% and 50% for those with rWIR < 2.3. ✔ The findings suggest that the predicted poor chemotherapy response with MRI is associated with shorter EFS and shows similar results to histological response evaluation, making rWIR a potential tool for future response-based individualized healthcare in osteosarcoma patients. ✔ Link: https://lnkd.in/eYyPk_Wv. ✔ Institutions: Leiden University Medical Center - Universiteit Gent - UZ Gent - Cancers MDPI ✔ Collaborators: Timo Kalisvaart, Richard Evenhuis, Willem Grootjans, Martijn Callens, Judith Bovee, David Creytens, Hans Gelderblom, Frank Speetjens, Lore Lapeire, Gwen Sys, Marta Fiocco, Michiel van de Sande, Koenraad Verstraete, Hans Bloem

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In addition to the cortical focus theory, based on studies in the WAG/Rij rat published by Radboud University Nijmegen (Meeren et al., 2002), we further unraveled the dynamic changes of the involvement of cortex and thalamus during generalized Spike-and-Wave discharges (SWDs) for human absence epilepsy using MEG. Gupta et al. (2011) showed that a cortical driving source initiates a cascade of events leading, as shown in the figure, to a repetitive pattern of bilateral synchronous generalized activity during the waves and bilateral focal frontal and parietal areas, with cortical involvement (Westmijse et al., 2009), during the spikes (Ossenblok et al., 2019). In a recent paper https://lnkd.in/gtRBTf24 the knowledge acquired in these studies was translated into ambulatory methods. Automated detection software was used to detect SWDs occurring in around-the-ears EEG arrays (cEEGrids) to capture 3-Hz short-lasting and ictal SWDs showing a similar course of bihemispheric synchrony, however, with a ‘dip’ preictally of the ictal versus the short-lasting SWDs. #Absences #SWDs #Ambulatory #cEEGrids #Automated #Detection #Bihemispheric #Synchrony  

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Did we accidentally make gold?! 🤔 Check out this stunning photograph taken by our colleague Maarten van Meerbeek during the synthesis of one of our fluorescent tracers for image-guided surgery! Lab work can be surprisingly beautiful sometimes…. #lumc #research #imageguidedsurgery #fluorescence #chemistry #gold #molecularimaging #tracer #surgery #nuclearmedicine #radiology #medicaltechnology #medicaldevices

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Check out the latest Renal Interventions profile, in which Bart Dolmatch shares his experiences as an interventional radiologist, his thoughts on the future of kidney care, and much more!

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US Patent Application published: “Variable Allele Frequency Threshold”, created together with former colleague Pieter Jan van der Zaag and former student Gino Raaijmakers https://lnkd.in/eRpmSRkB This invention relates to monitoring a patient's response to therapy. In order to improve the monitoring of a patient's response to therapy, a method is provided to set a plurality of allele frequency thresholds to accounting for variations among tumours and patients. As the multiple allele frequency thresholds take into account differences between genes, single-nucleotide polymorphisms (SNPs), and/or patients, the multiple allele frequency thresholds may provide significant value to improve personalized therapy selection, disease surveillance, and monitoring to improve patient outcomes. #personalizedmedicine #liquidbiopsy #snp #genomics #cancer #oncology #allelefrequency

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