Human-relevant models are needed to predict the potency of novel pharmaceuticals to induce liver toxicity, which means researchers must detect DILI effects using in vitro human models. Head over to our website to learn how we use ToxProfiler to guide DILI predictions 👉 https://lnkd.in/d46vcrgm #toxprofiler #toxicology #nams #pharmaceuticals
Toxys
Onderzoeksdiensten
Genetic, developmental, and mechanistic toxicology with New Approach Methodologies (NAMs)
Over ons
Toxys is global leading expert that develops and offers a broad spectrum of unique animal-free laboratory tests for the safety assessment of novel medicines, chemicals, cosmetics and food. We are experts in the fields of genotoxicity, developmental toxicology and mechanistic toxicity testing. We develop assays with the focus on understanding the mode-of-action of toxic compounds. Our ToxTracker® assay accurately identifies genotoxic compounds, ReproTracker® detects developmental toxicity and the ToxProfiler™ assay provides a broad toxicity profile of compounds. Our unique assays provide relevant information to avoid compounds failing at a late stage of development due to unforeseen toxicity. We aim to bring information to our customers that is essential to make informed decisions on which compounds to progress in drug/compound development, thereby contributing to the development of better medicines and products and to reduce animal testing. Every novel chemical compound that is developed by pharmaceutical, chemical, cosmetics or food companies has to be rigorously tested for human health hazards before being considered safe for marketing. Current in vitro toxicity tests, which are an essential part of compound risk assessment, often suffer from a low predictive value and lack the possibility to provide insight into the mode-of-action of toxic compounds. To address these unmet needs, Toxys offers a diverse portfolio of in vitro assays that provide mode-of-action information on toxic compounds and provide information relevant to human health. The assays are used for early compound screening, follow-up testing and mode-of-action assessment, potency ranking and chemical read-across and are particularly useful in weight-of-evidence (WoE) and adverse outcome pathway (AOP) approaches for chemical safety assessment. Toxys is internationally recognised for its scientific expertise, high-quality results and responsiveness.
- Website
-
http://www.toxys.com
Externe link voor Toxys
- Branche
- Onderzoeksdiensten
- Bedrijfsgrootte
- 2-10 medewerkers
- Hoofdkantoor
- Oegstgeest
- Type
- Naamloze vennootschap
- Opgericht
- 2014
- Specialismen
- Genotoxicity testing, Mechanism-based toxicology, DNA damage response, Mammalian reporter assays, Stem cells en BAC technologies
Locaties
-
Primair
De Limes 7
Oegstgeest, 2342 DH, NL
Medewerkers van Toxys
Updates
-
Our CEO Giel Hendriks and CBO Paula van Rossum recently joined the online seminar facilitated by Masashi MATSUNAGA, Ph.D. CEO of Biospire and supporter of Life Science Innovation Network Japan (LINK-J) to talk about our NAMs portfolio. The recording is now available on YouTube, which you can freely access here (partly Japanese) 👉 https://lnkd.in/d3hkJnXQ Did you know that Toxys also has a website in Japanese? You can check it out here 👉 https://lnkd.in/dg9gKBJC
-
-
Are 2 or 7 day hiPSC/hESC differentiation assays sufficient for developmental toxicity prediction or do they lead to misclassifications of compounds for teratogenicity? Comparing results from TeraTox and DevTox assays to those from our ReproTracker assay for multiple compounds, we showed that we were able to predict in vivo classifications with higher accuracy (94%), specificity (94%), and sensitivity (93%). Curious about the details? Please request this poster via the form below 👇 https://lnkd.in/dwMmrAWG #NAMs #ReproTracker #devtox #toxicology #stemcells
-
-
A reminder that a practical ToxTracker workshop is coming up in August in the United States. Don't miss this great chance to get hands-on experience with our assay.
📅 Register now for an in-depth workshop focusing on the ToxTracker assay, developed by Toxys Inc. and offered by IIVS. Dates: August 15-16, 2024 Location: IIVS HQ, Gaithersburg, Md. Participants will be able to view and participate in the conduct of the assay in the lab and hear from IIVS and guest speakers about the science behind the assay, its applications, and regulatory status. Find out more: https://lnkd.in/g-6TFN3u Register: https://lnkd.in/gFekUpbF
-
-
There are a limited number of in vitro assays which aim to detect potential teratogens. These include the human pluripotent stem cell test (hPST), the TeraTox and the DevTox Germ Layer Reporter Platform (DevTox GLR). They are of a short duration and possible to complete within a week. However, is this saving on assay duration at the cost of the overall accuracy of the assay? Head over to our website for the answer: https://lnkd.in/dhZk9HZ3 #reprotracker #devtox #developmental #toxicology #nams #invitro
-
-
Have you read our case study where we tested 68 chemicals with ToxTracker and compared the results to in vitro and in vivo micronucleus assay data? Head over to our blog for the full article as well as a PDF downloadable. https://lnkd.in/dFfMB_Nx #toxtracker #genotoxicity #nams
-
-
Join us next Wednesday at 4:00 PM JST for an exclusive session with Masayuki Matsunaga from Biospire! We'll dive into the latest advancements in safety testing in Europe, where there is an increase in the adoption of new approach methods (#NAMs) that may eliminate the need for laboratory animals. Don't miss this opportunity to learn about our cutting-edge assays! 📝 Register now to secure your spot: https://lnkd.in/ekiGmjxW
-
-
Did you miss our webinar on developmental and reproductive toxicology and how integrating ReproTracker into AOPs can guide decisions? You can now request the recording via our website. Just follow the link below! https://lnkd.in/dsSFtedB
-
-
Next week, we will join Venn Life Sciences in below webinar and talk about our stem cell-based assays for genotoxicity and developmental toxicity testing. If you are interested in learning more about #NAMs in therapeutics development, you are welcome to sign up via the event page: https://lnkd.in/e6ZMjyVR #thenamscompany #toxicology #drugdevelopment
Toxys & Venn Life Sciences are teaming up to share insights on the possibilities for use of alternative methods in drug development! Will you join us Since studies with animals not always predict accurately for human responses, the search for alternative methods has been intensified in the last decades. Better predictive non-animal models will decrease the change of failure during late stage clinical drug development. In this upcoming webinar, we will present current legislation on animal testing and possibilities to use alternative methods in drug development and showcase a real-world case study. Venn will cover the legislative aspects, while Toxys will highlight their ReproTracker® and ToxTracker® assay, an innovative in vitro method. Together, we will demonstrate how these approaches can provide reliable and relevant data in drug development. Key learnings to look forward to: - Current viewpoints from regulatory authorities - Ethical consideration and potential impact on R&D - Existing alternative methods in drug development - Strategies for incorporating these methods into R&D - Succesful case study using alternative methods We welcome any questions you have in advance for our speakers Giel Hendriks and André Wolterbeek. So, don't be shy! To register for the webinar you can simply click attend on this LinkedIn event and we will share the registration details. See you July 2nd? #drugdevelopment #toxicology #nonclinical
-
Check out this presentation from Unilever on their use of ReproTracker within the Next Generation Risk Assessment (NGRA) framework. They have shared valuable insights into their developmental and reproductive toxicology testing strategy in this presentation during ESTIV 2024. If you would like to learn more about ReproTracker and how it is integrated into different testing strategies, please visit our service page or reach out to us. Unilever presentation 👉 https://lnkd.in/dBvUR6qY ReproTracker assay 👉 https://lnkd.in/e_eCGwts #toxicology #nams Jade Houghton
-
Gerelateerde pagina’s
Vergelijkbare pagina’s
Door vacatures bladeren
Financiering
Laatste ronde
Serie onbekendUS$ 2.236.529,00