SMART OoC heeft dit gerepost
Full Professor of Microphysiological Systems and Organ-on-a-Chip at University of Twente, The Netherlands
How do you know your #organonachip #OoC is actually relevant as a model for the human biology in which you are interested? And how do developers of these #microphysiological systems know how their device holds up compared to other existing in vitro and in vivo models? Answering these questions is vitally important for uptake by end-users! In this extensive paper, Dennis, Renée, myself and many others of the Netherlands Organ-on-Chip Initiative (NOCI) argue that we need to step away from descriptive parameters and endpoints. Instead, we should work with hard, quantitative data when developing and evaluating organ-on-chip models. A lot of work went into this piece, go check it out!
For anyone interested in MPS and OoC ! One of the proudest achievements from my PhD journey is now online: The Netherlands Organ-on-Chip Initiative (NOCI) consortium perspective on microphysiological systems (MPSs) and organs-on-chip (OoCs), which I co-first authored with Renée Moerkens, is published in Nature Biomedical Engineering! 📚✨ Studies using MPS have predominantly been descriptive so far. To fully realize their potential in advancing our understanding of human disease and improving drug development, a next step is essential. ⚠ In this Perspective, we: - Highlight the necessity of quantitatively comparing physiological observations in OoCs with human values. 📊 - Provide a practical framework by distinguishing between > designed features - directly influenced by OoC design upfront > emergent features - describing cellular functioning developed autonomously within the chip - Demonstrate this with an extensive table and discussion of published quantifiable physiological features comparing OoC and human data, specifically for the vasculature, intestine, brain, and heart. Furthermore, we: - Discuss novel methods and technologies that could improve or enable the quantification of physiological features in various types of OoCs. 🔜 🚀 Applying these principles will progress the development of measurable standards that allow us to compare different MPSs directly and assess their relevance to the human body. 🌟 This will elevate MPS and OoC to the next level, facilitating the development of more relevant and complex in vitro models with wider end-user adoption and regulatory acceptance. Leading and organizing this project with the incredibly talented Renée Moerkens has been one of the greatest challenges and joys throughout my PhD. A huge thank you to everyone involved, especially the entire NOCI consortium for laying the scientific foundation and enabling the human connections necessary for such a collaborative effort. Thanks to all authors for their valuable discussions and contributions. 🙏 Full-text access here: https://rdcu.be/dR0sK Link to the article on the NBE site: https://lnkd.in/dHDCcu6P