To celebrate that we have more than 2000 followers, we have made a video in some of our #NOCI laboratories, to show our work combining cell biology and technology to push organs-on-chip to the next level! If you want to know more about what we do with the other partners of the #NOCI initiative, stay tuned to don't miss our updates! Special thanks to the #NOCI members in the video: Renée Moerkens, Joram Mooiweer, Jeroen Stein, Dennis Nahon and Mariia Zakharova. And special acknowledgments to José Manuel Rivera Arbeláez for editing the video! #NOCI #OoC #organonachip #UMCG #LUMC #UTWENTE University of Twente Leiden University Medical Center UMCG
Netherlands Organ-on-Chip Initiative (NOCI)
Onderzoeksdiensten
NOCI works towards making miniature organs on a chip and using them to study how diseases develop and can be treated
Over ons
In our ageing society, it is more important than ever to develop treatments of devastating chronic diseases. Yet, what appears promising in the lab, often falls short in the clinical practice. We aim to develop a new platform to better predict the effect of medicines, based on a combination of human stem cells and microchips. In this way, we learn much more about the development of diseases and accelerate the discovery of new medicines.
- Website
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https://noci-organ-on-chip.nl/
Externe link voor Netherlands Organ-on-Chip Initiative (NOCI)
- Branche
- Onderzoeksdiensten
- Bedrijfsgrootte
- 201 - 500 medewerkers
- Hoofdkantoor
- Leiden
- Type
- Non-profit
- Opgericht
- 2017
- Specialismen
- The Netherlands Organ-on-Chip Initiative is an NWO Gravitation project funded by the Ministry of Education, culture and Science of the government of the Netherlands.
Locaties
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Primair
Routebeschrijving
Leiden University Medical Center (LUMC)
Postal Zone S4-P P.O. Box 9600
Leiden, 2300 RC Leiden, NL
Medewerkers van Netherlands Organ-on-Chip Initiative (NOCI)
Updates
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Congratulations to our #NOCI researcher Dennis Nahon, who defended his thesis titled "Modeling vascular disease using self-assembling human induced pluripotent stem cell derivatives in 3D vessels-on-chip" at the Leiden University Medical Center. His work was supervised by Prof. Christine Mummery and Dr. Valeria Orlova. We are happy to congratulate Dr. Nahon and wish him the best of luck in his next adventure. #NOCI #phd #LUMC #OoC #organonchip
Dr. Dennis Nahon It still feels surreal, but I have to admit, it has a nice ring to it. After 5 years of hard work, the official moment finally arrived on June the 26th. I successfully defended my PhD titled: ‘Modeling vascular disease using self-assembling human induced pluripotent stem cell derivatives in 3D vessels-on-chip’. Guided and supported by the inspirational Christine Mummery and the brilliant Valeria Orlova, it has been an incredible journey delving into the complexities of stem cell biology, vascular biology, disease modeling, vessel-on-chip and organ-on-chip technologies. Not to forget overcoming and learning from the personal challenges that come with such an intense PhD journey. A big thank you to all my colleagues, friends and family who supported me throughout these years. Here’s to new (and still unknown) adventures ahead!
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Check the latest publication from our #NOCI researcher Dennis Nahon from Leiden University Medical Center. He explains in the post below the key outcomes of this scientific publication, available in Stem Cell Reports. #NOCI #LUMC #OoC #vesselonchip
Happy days! Why, you ask? Because my main PhD project (yes, it feels like my baby) is now available for everyone to read in Stem Cell Reports! https://lnkd.in/dQbisByy The Goal: To develop a 3D in vitro model of the blood-brain barrier (BBB) to facilitate the study of complex neurodegenerative disorders. Key Outcomes: ✅ We successfully developed perfusable 3D microvascular networks containing hiPSC-derived endothelial cells, pericytes, and hiPSC-derived astrocytes within a Vessel-on-Chip device. 🔄 We confirmed that hiPSC-derived astrocytes can replace commonly used primary astrocytes, exhibiting similar phenotypes and interactions. ⚠ Unexpectedly, the inclusion of hiPSC-derived astrocytes initially disrupted microvascular network formation. 💡 However, this challenge was resolved through continuous fluid perfusion or activation of cAMP signaling. Our report on this evolving model highlights potential challenges, proposes solutions and underscores the importance of reporting biological variability for anyone creating or using similar models. A special thanks to Marc Vila Cuenca, for the incredible support. And of course all other co-authors including Lisa van den Hil, Tessa de Korte, Michel Hu an JP Frimat!
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On the last day of the EUROoCS 2024 conference in Milan, our #NOCI researchers had the opportunity to share their results. Specifically, Alireza Tajeddin and Feyza Pirim from Delft University of Technology, and Laura de Heus and José Manuel Rivera Arbeláez from the Universiteit Twente. During the conference, we had the opportunity to be represented by a nice group: Elena Aprea, Vasiliki Gkouzioti, JP, Tarek Gensheimer, Laura de Heus, Feyza Pirim, Alireza Tajeddin, Verena Schwach, Joshua Loessberg-Zahl, Maurits Unkel and José Manuel Rivera Arbeláez. #NOCI #EUROOCS2024 #OoC #organonchip
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Our #NOCI researchers are present at the EUROoCS conference 2024 in Milan! Yesterday our #NOCI PI Andries van der Meer presented the Focus Group Organ-on-Chip Standardisation Roadmap. Tarek Gensheimer, Lena Sophie Koch and Verena Schwach from the University of Twente gave impressive talks about the advantages of using OoC to address complex biological questions. Then, at the poster session, Elena Aprea from Delft University of Technology and Vasiliki Gkouzioti from Leiden University Medical Center showed their latest results. If you are at the conference don't miss the opportunity to connect with our NOCI researchers. #NOCI #EUROOCS2024 #OOC #organonchip
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#NOCI Troppo Breve V has concluded after an incredible four days of discussions on the latest results by the researchers from the different universities and on how to bring organ-on-chip technology to the next level in #NOCI phase 2. A big thank you to the UMCG #NOCI team (Iris Jonkers, Sebo Withoff and Hélène Lauvenberg) for the organization. Stay tuned for updates #NOCI #OoC #organonachip
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The work on "Stem cell derived Vessels-on-Chip to study brain disorders" by our #NOCI researcher Dennis Nahon from the Leiden University Medical Center, was highlighted by the Transitie Proefdiervrije Innovatie. Check out the video in the post below! #NOCI #OOC #organonchip #vesselonchip
The field of organ-on-chips is moving fast, producing more complex and robust systems that model a plethora of organs in the human body. In this video series, four PhDs show their hard work, for which they won a prize at the last hDMT Organ-on-Chip Consortium consortium meeting. Well deserved! You can find these videos of Huub Weener, Theano Tsikari, Beatrice Gabbin and Dennis Nahon and more about innovation for the transition to animal-free research on TPI TV https://lnkd.in/eXu2Bdt4 #animalfree #transitionanimalfreeinnovation #video #tpi
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The #NOCI Troppo Breve V meeting kicked off yesterday with a warm welcome from the UMCG #NOCI team and an inspiring opening talk by Christine Mummery. For the next three days, we'll be exploring and discussing the latest findings from our #NOCI members. Stay tuned for updates and don't miss any of the exciting developments! #NOCI #OoC #organonachip
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Congratulations to our #NOCI researcher Eline Smits from UMCG, who won the NCV incentive prize at the Nederlandse Coeliakie Vereniging gluten-free festival last Saturday. She presented her work on celiac disease using her gut-on-chip model to patients and family members. #NOCI #OoC #gutonchip
Een geweldige dag afgelopen zaterdag, te gast bij het glutenvrij festival van de Nederlandse Coeliakie Vereniging. Onder het mom ‘ontmoet de onderzoeker’ kregen Jelle Slager en ik de kans om met patiënten en familieleden in gesprek te gaan over ons onderzoek naar coeliakie. Dit leverde interessante gesprekken op. Het was een waardevolle ervaring om bij deze dag aanwezig te mogen zijn. Als hoogtepunt kreeg ik tijdens deze dag de NCV-stimuleringsprijs uitgereikt om verder onderzoek te doen naar de darmwand bij coeliakie. Het is een hele eer om deze prijs te mogen ontvangen! Met dit project willen wij meer inzicht verkrijgen in het ziekteproces bij coeliakie met behulp van ons darm-op-chip model. Wat gebeurt er in het darmepitheel bij mensen met deze ziekte als zij gluten binnen krijgen en hoe verschilt dit met mensen die niet coeliakie hebben? Graag zou ik alle NCV-leden, de NCV, patiënten en familieleden, Sebo Withoff en Iris Jonkers, de Immunogenetics groep (Shout-out naar Renée Moerkens en Joram Mooiweer voor de grondslag van ons darm-op-chip model) en ook mede-onderzoekers en Netherlands Organ-on-Chip Initiative (NOCI) willen bedanken: onderzoek doen is een team effort!
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Netherlands Organ-on-Chip Initiative (NOCI) heeft dit gerepost
Today is Europe Day. 🌍⭐ We celebrate innovation, discovery, and collaboration in research across our diverse continent. The European Research Council (ERC) regularly supports research at the EEMCS faculty through grants. Like the research of Dr. Clementine Boutry who received a prestigious ERC Starting grant for her groundbreaking research on biodegradable implants that can repair nerves. Each year, an estimated 300,000 cases of trauma-related nerve injuries occur in Europe. For large injuries, less than 25% of patients recover proper motor function and less than 3% regain sensation. Accelerating nerve regrowth is a key factor, as the disconnected part of the nerve dies quickly after the injury. Therefore, it is truly a race against time. Dr. Boutry’s research focuses on a new therapeutic approach: using biodegradable implants to stimulate the nerves to accelerate their regrowth. #EuropeDay #EU #ResearchCollaboration #ERCgrant #ERC #research #biodegradable #implants
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